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Discovery Early Career Researcher Award - Grant ID: DE220100757
Funder
Australian Research Council
Funding Amount
$447,654.00
Summary
Engineering Tissue Organisation Using Intelligent Additive Biomanufacturing. This project aims to organize and shape the formation of lab-grown tissue by 3D printing structures which control the behaviour of cells. This cell behaviour control will be accomplished through an interdisciplinary and multiscale pipeline of additive micromanufacturing, bioreactor engineering, cell culture, single-cell imaging, and computational modelling. In contrast with current empirical approaches, this quantitativ ....Engineering Tissue Organisation Using Intelligent Additive Biomanufacturing. This project aims to organize and shape the formation of lab-grown tissue by 3D printing structures which control the behaviour of cells. This cell behaviour control will be accomplished through an interdisciplinary and multiscale pipeline of additive micromanufacturing, bioreactor engineering, cell culture, single-cell imaging, and computational modelling. In contrast with current empirical approaches, this quantitative and predictive understanding of how to control biological processes within 3D printed environments will design and engineer more robust, customisable, scalable, and economical cell culture platforms able to optimally manufacture bespoke and complex 3D tissues for future agricultural, pharmaceutical, or medical products.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100909
Funder
Australian Research Council
Funding Amount
$425,523.00
Summary
3D micro-bioprinting: acoustic actuation to shape single-cell organization. This project aims to develop an innovative cell-printing technology to replicate the microscale cell structure found in native human and animal tissues. This is based on an interdisciplinary concept that combines ultra-high frequency acoustic cell manipulation with 3D stereolithography printing, and will examine acoustic waveguide element design and their topological optimisation. In contrast to current 3D printing metho ....3D micro-bioprinting: acoustic actuation to shape single-cell organization. This project aims to develop an innovative cell-printing technology to replicate the microscale cell structure found in native human and animal tissues. This is based on an interdisciplinary concept that combines ultra-high frequency acoustic cell manipulation with 3D stereolithography printing, and will examine acoustic waveguide element design and their topological optimisation. In contrast to current 3D printing methods that are not suitable for precisely integrating microscale elements in the printing process, this work will open up the range of materials, including functional human tissues, that can be printed.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100229
Funder
Australian Research Council
Funding Amount
$293,920.00
Summary
Ultra-low field magnetic resonance imaging with an array of localised magnetic field sensor . The aim of this project is to design and construct a multifunctional ultra-low magnetic field (ULF) magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) instrument equipped with novel magnetic field sensors. This project is significant because it will deliver an instrument with enhanced sensitivity which is capable of obtaining non-invasive three-dimensional structural imaging of sample ....Ultra-low field magnetic resonance imaging with an array of localised magnetic field sensor . The aim of this project is to design and construct a multifunctional ultra-low magnetic field (ULF) magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) instrument equipped with novel magnetic field sensors. This project is significant because it will deliver an instrument with enhanced sensitivity which is capable of obtaining non-invasive three-dimensional structural imaging of samples. This instrument will enable operation of highly sensitive ULF-MRI or ULF-NMR with regenerative energy sources and be a low-cost solution; reducing operation and maintenance costs as well as power consumption.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100241
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Seeing deeply inside the body with the world's smallest microscope. This project aims to develop the world's smallest in vivo microscope that can image the interior of living organisms at a subcellular resolution in a minimally invasive way. The project will shrink an entire microscope to the size of an optical fibre – as thin as a single strand of hair – and image deep regions of the central nervous system. This is expected to improve diagnostic tools and the knowledge of degenerative brain dis ....Seeing deeply inside the body with the world's smallest microscope. This project aims to develop the world's smallest in vivo microscope that can image the interior of living organisms at a subcellular resolution in a minimally invasive way. The project will shrink an entire microscope to the size of an optical fibre – as thin as a single strand of hair – and image deep regions of the central nervous system. This is expected to improve diagnostic tools and the knowledge of degenerative brain diseases, including Alzheimer's disease and amyotrophic lateral sclerosis. This project aims to completely transform the landscape of biomedical research and industry, with expected discoveries revolutionising the diagnosis and treatment of brain conditions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100009
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Spatial, spectral and temporal imaging through multimode optical fibre. This project aims to develop technologies for imaging through a multimode fibre that controls and measures each property of light; amplitude, phase, polarisation, wavelength and space as it propagates through an optical fibre. This will be pursued through the development of three prototype systems, where each system targets a particular property of light. The outcomes would ultimately enable multimode fibres to act as ultrac ....Spatial, spectral and temporal imaging through multimode optical fibre. This project aims to develop technologies for imaging through a multimode fibre that controls and measures each property of light; amplitude, phase, polarisation, wavelength and space as it propagates through an optical fibre. This will be pursued through the development of three prototype systems, where each system targets a particular property of light. The outcomes would ultimately enable multimode fibres to act as ultracompact, general-purpose optical conduits into the body through which a wide array of biomedical techniques can be performed in a minimally invasive fashion not currently possible. This project will provide significant benefit to the study of fundamental phenomena in optical fibres.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100302
Funder
Australian Research Council
Funding Amount
$461,300.00
Summary
A long-lasting interface for communicating with the brain. This project aims to address the most urgent challenges in developing the next generation of implantable devices for communicating with the brain. Using a new type of carbon-based electrode, along with light therapy, this project expects to build innovative technologies that can greatly enhance the functionality and longevity of these devices. Expected outcomes include a novel tool that can be implemented to obtain detailed insights into ....A long-lasting interface for communicating with the brain. This project aims to address the most urgent challenges in developing the next generation of implantable devices for communicating with the brain. Using a new type of carbon-based electrode, along with light therapy, this project expects to build innovative technologies that can greatly enhance the functionality and longevity of these devices. Expected outcomes include a novel tool that can be implemented to obtain detailed insights into neural circuits, advancing our understanding of neural function and pioneering feedback and closed-loop neuroscience. This project should provide significant benefits in neuroscience research and the neural interface industry, both of which have the ultimate goal to unlock the mysteries of the brain.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100843
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Regulating gene delivery with light. This project seeks to deliver the capacity to remotely deliver molecules into specific cells without the need for invasive or viral procedures. Individual genetic predisposition to disease forms a key part of personalised medicine that requires the accurate delivery of drugs or genes. This project aims to develop a new multimodality microscopy that can investigate and optimise light delivery of macromolecules into living cells at high specificity and across a ....Regulating gene delivery with light. This project seeks to deliver the capacity to remotely deliver molecules into specific cells without the need for invasive or viral procedures. Individual genetic predisposition to disease forms a key part of personalised medicine that requires the accurate delivery of drugs or genes. This project aims to develop a new multimodality microscopy that can investigate and optimise light delivery of macromolecules into living cells at high specificity and across a multitude of cells. The expected outcome of this project is a new form of in vivo molecular delivery system using light.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100128
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Engineering microenvironments to regulate osteocyte 3D networks in vitro. Most knowledge of bone is based on only a fraction of cells found in bone because the majority of cells in our bones (called osteocyte cell networks) cannot easily be grown or studied outside the body. This results in the inability to understand how the bone organ functions. Using bioinspired engineering, this project will use advanced biomaterials to biofabricate, for the first time, osteocyte cell networks in vitro. By u ....Engineering microenvironments to regulate osteocyte 3D networks in vitro. Most knowledge of bone is based on only a fraction of cells found in bone because the majority of cells in our bones (called osteocyte cell networks) cannot easily be grown or studied outside the body. This results in the inability to understand how the bone organ functions. Using bioinspired engineering, this project will use advanced biomaterials to biofabricate, for the first time, osteocyte cell networks in vitro. By unravelling how they are formed and controlled by manipulating their microenvironment, we will discover how different types of bones are formed. The benefits will be a valuable tool for the bone research community, allowing unresolved questions to be addressed in the future, such as how bone forms, repairs, and remodels.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101133
Funder
Australian Research Council
Funding Amount
$358,551.00
Summary
Linking structure and function: a new approach for understanding the lung. This project aims to develop a powerful analysis tool to measure gas transport and mixing within lungs. This project will study the mechanical workings of the lungs, using an innovative approach for analysis of lung images. The expected outcome of this project is a novel platform for investigation and understanding of lung function. It is anticipated that application of the project outcomes to medical challenges in the lo ....Linking structure and function: a new approach for understanding the lung. This project aims to develop a powerful analysis tool to measure gas transport and mixing within lungs. This project will study the mechanical workings of the lungs, using an innovative approach for analysis of lung images. The expected outcome of this project is a novel platform for investigation and understanding of lung function. It is anticipated that application of the project outcomes to medical challenges in the long-term will lead to improved diagnostics and treatments for lung diseases.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102210
Funder
Australian Research Council
Funding Amount
$350,333.00
Summary
Feedback control as a tool for enhanced neuroprosthetic stimulation. The aim is to use control theory tools to find optimal stimulation parameters to use in a bionic implant. This project will lead to improvements in understanding of mechanisms underlying electrical stimulation and to improvements in medical bionics technologies.