Biomechanics of Needle Insertion. Needle insertion is one of the most common neurosurgical procedures. However, the biomechanics of this process is poorly understood. The unknown factors include brain tissue deformation under load imposed by the needle and needle deflection when penetrating brain tissue. We will develop computational models of needle insertion. They will include non-linear material properties of the brain tissue, large deformations, and needle-tissue contact model including fric ....Biomechanics of Needle Insertion. Needle insertion is one of the most common neurosurgical procedures. However, the biomechanics of this process is poorly understood. The unknown factors include brain tissue deformation under load imposed by the needle and needle deflection when penetrating brain tissue. We will develop computational models of needle insertion. They will include non-linear material properties of the brain tissue, large deformations, and needle-tissue contact model including friction. The Japanese group will develop testing methods to validate mathematical models. Experimental set-up includes bi-axial x-ray to measure deformation within the tissue and needle deflection, and a sensor measuring reaction force on needle tip and friction force on needle sides.Read moreRead less
Computational biomechanics for image-guided neurosurgery. Our results will lead to significant improvements to the efficacy and efficiency of image-guided neurosurgery for brain tumours. Visualisation of the intra-operative configuration of the patient's brain, obtained by sparse intra-operative MRI, merged with high resolution pre-operative imaging data will become possible. In current practice, the neurosurgeon must mentally fuse the information from pre-operative fMRI and DTI by projecting it ....Computational biomechanics for image-guided neurosurgery. Our results will lead to significant improvements to the efficacy and efficiency of image-guided neurosurgery for brain tumours. Visualisation of the intra-operative configuration of the patient's brain, obtained by sparse intra-operative MRI, merged with high resolution pre-operative imaging data will become possible. In current practice, the neurosurgeon must mentally fuse the information from pre-operative fMRI and DTI by projecting it through the 3D spatial and temporal changes the patient's brain has undergone. We propose to replace this mental fusion with computations based on the biomechanical model that will allow visualisation of the transformed pre-operative data matched to the current shape of the patient's brain.Read moreRead less
Techniques for probing biological media with holographic angular scattering spectroscopy. Huge effort in the biological and medical sciences is spent in using simple software to laboriously mark, count and measure cells and structures in microscope images of samples. We could replace this incredibly inefficient process in many instances with single-shot size-map images of unstained samples. If depth selectivity can be added, we could perform non-invasive measurements on animals, making a huge re ....Techniques for probing biological media with holographic angular scattering spectroscopy. Huge effort in the biological and medical sciences is spent in using simple software to laboriously mark, count and measure cells and structures in microscope images of samples. We could replace this incredibly inefficient process in many instances with single-shot size-map images of unstained samples. If depth selectivity can be added, we could perform non-invasive measurements on animals, making a huge reduction in their usage. We could assess thick tissues enabling early noninvasive diagnosis of malignancy in tumours in situ or muscle characterization for meat quality or muscular dystrophy. These benefits impact on research, animal ethics, and on health, and have commercial potential in life and medical sciences, and the meat industry.Read moreRead less
The kinematics of the anterior eye deformation. This project has a potential to benefit Australia from a number of perspectives. The outcomes will provide ophthalmologists and optometrists with currently unavailable knowledge on dynamic behaviour of eye. In particular the research will identify aspects of corneal deformation that in turn will help improve the accuracy of refractive surgeries and aid in the management of glaucoma. Also, the knowledge generated through this project will be of valu ....The kinematics of the anterior eye deformation. This project has a potential to benefit Australia from a number of perspectives. The outcomes will provide ophthalmologists and optometrists with currently unavailable knowledge on dynamic behaviour of eye. In particular the research will identify aspects of corneal deformation that in turn will help improve the accuracy of refractive surgeries and aid in the management of glaucoma. Also, the knowledge generated through this project will be of value to engineers designing advanced clinical instrument for measuring eye parameters. Read moreRead less
Development of an integrated methodology to assess dewatering system performance in solid-liquid separation. 3D visualisations of microstructures are possible with techniques such as confocal laser microscopy and high resolution X-ray microtomography. Data obtained in-situ enable direct computation of solids assembly properties and their permeability to fluids. A specific application involving aggregate formation and sediment networks could be evaluated through micro-scale analysis combined with ....Development of an integrated methodology to assess dewatering system performance in solid-liquid separation. 3D visualisations of microstructures are possible with techniques such as confocal laser microscopy and high resolution X-ray microtomography. Data obtained in-situ enable direct computation of solids assembly properties and their permeability to fluids. A specific application involving aggregate formation and sediment networks could be evaluated through micro-scale analysis combined with robust fluid flow simulations. The method can potentially be utilized to predict trends such as filtration behaviour of materials under different states of compression. This offers significant benefits in formulating the design of flocculated systems pertinent to a number of industrial sectors wishing to design optimum solid-liquid separation processes.Read moreRead less
Advanced materials and structures for terahertz science and technology. Anthrax, explosives, water, cancer all have characteristic signatures in the terahertz (THz) part of the electromagnetic spectrum. Security, defence, agriculture, medicine are some of the fields where THz science and technology are booming. THz developments offer enhanced national security, prosperity and quality of life. The lack of strong sources of THz radiation is the main factor hampering wider application of THz metho ....Advanced materials and structures for terahertz science and technology. Anthrax, explosives, water, cancer all have characteristic signatures in the terahertz (THz) part of the electromagnetic spectrum. Security, defence, agriculture, medicine are some of the fields where THz science and technology are booming. THz developments offer enhanced national security, prosperity and quality of life. The lack of strong sources of THz radiation is the main factor hampering wider application of THz methods. In this project two university research teams come together to develop more efficient THz emitters. The Darmstadt team will prepare novel materials and structures and the Wollongong team will evaluate them and provide feedback for the next iteration.Read moreRead less
An Integrated Bridge Monitoring System Based on the GPS and Pseudolite Technologies. Global Positioning System (GPS) technology can be used for precise deflection measurement of manmade structures such as buildings, bridges, etc. When integrated with additional signals from pseudolites (PL) that transmit GPS-like signals, changes in the height(s) of the monitored point(s) can be measured to millimetre accuracy. In collaboration with University of Nottingham researchers, a bridge structure in the ....An Integrated Bridge Monitoring System Based on the GPS and Pseudolite Technologies. Global Positioning System (GPS) technology can be used for precise deflection measurement of manmade structures such as buildings, bridges, etc. When integrated with additional signals from pseudolites (PL) that transmit GPS-like signals, changes in the height(s) of the monitored point(s) can be measured to millimetre accuracy. In collaboration with University of Nottingham researchers, a bridge structure in the U.K. will be used as a testbed, and will be the first time that PLs have been used for such an application. The expected outcomes include a suite of deformation monitoring algorithms capable of online analysis of the combined GPS-PL outputs.Read moreRead less
Active polymer surfaces for control of fluid movement. The realisation of a diverse array of remote or portable chemical/biological monitoring systems depends on the development of low power fluid management protocols. The use of appropriate conducting polymer surfaces should enable this to occur. We envisage the integration of these fluid management platforms into portable, remote autonomous monitoring systems for environmental industrial and biomedical applications.
CHAMP GPS-Altimetry. The proposed research project aims to develop a novel application for the Global Positioning System (GPS), namely the use of GPS signals reflected from sea- or ice-surfaces and received by Low-Earth-Orbiter (LEO) for determination of these surface heights. Data from the German satellite CHAMP will be used for this purpose, for selected regions in Antartica. CHAMP covers areas not visited by other remote sensing satellites. The Fellow is instrumental for obtaining and process ....CHAMP GPS-Altimetry. The proposed research project aims to develop a novel application for the Global Positioning System (GPS), namely the use of GPS signals reflected from sea- or ice-surfaces and received by Low-Earth-Orbiter (LEO) for determination of these surface heights. Data from the German satellite CHAMP will be used for this purpose, for selected regions in Antartica. CHAMP covers areas not visited by other remote sensing satellites. The Fellow is instrumental for obtaining and processing these CHAMP data.
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Multiphoton microscopy through tissue turbid media. The aim of this proposal is to conduct the collaborative project on multi-photon microscopic imaging through biological tissue, which has been recently initiated between Swinburne University of Technology (SUT) and Massachusetts Institute of Technology (MIT). It will integrate the special skills, two-photon fluorescence endoscopy and second-harmonic coherence tomography, investigated in the respective collaborating institutes, to develop a nove ....Multiphoton microscopy through tissue turbid media. The aim of this proposal is to conduct the collaborative project on multi-photon microscopic imaging through biological tissue, which has been recently initiated between Swinburne University of Technology (SUT) and Massachusetts Institute of Technology (MIT). It will integrate the special skills, two-photon fluorescence endoscopy and second-harmonic coherence tomography, investigated in the respective collaborating institutes, to develop a novel method for detecting/imaging cancer cells that are located at 1 mm below tissue surfaces, while they are still in the early stage to be cured. Consequently, a diagnostic method for early cancer detection particularly through skin tissue becomes possible.Read moreRead less