Intelligent training (iTraining) for the human Achilles tendon. The project aims to improve understanding of the mechanical environment of the Achilles tendon. The Achilles tendon plays a crucial role in human motor function and is also a structure that is commonly injured and notoriously difficult to treat. A major barrier to improving Achilles tendon function, preventing tendon injury and enhancing tendon repair is a poor understanding of the mechanical environment of the Achilles tendon durin ....Intelligent training (iTraining) for the human Achilles tendon. The project aims to improve understanding of the mechanical environment of the Achilles tendon. The Achilles tendon plays a crucial role in human motor function and is also a structure that is commonly injured and notoriously difficult to treat. A major barrier to improving Achilles tendon function, preventing tendon injury and enhancing tendon repair is a poor understanding of the mechanical environment of the Achilles tendon during training and rehabilitation. The project aims to develop a better understanding of the loading conditions that optimise tendon metabolism. Based on this, it then intends to develop new technologies to estimate the mechanical behaviour of the human Achilles tendon in real time based on integrated use of wearable technology, and new training guidelines that will optimise human tendon adaptation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100078
Funder
Australian Research Council
Funding Amount
$190,000.00
Summary
An advanced multimodal terahertz spectroscopy and imaging system for WA. An advanced multimodal terahertz spectroscopy and imaging system: Terahertz (THz) technology is in use in diverse applications from semiconductor inspection, metamaterials, biology and protein analysis, pharmaceutical sciences and formulations; security and surveillance, and biomedical imaging for burn assessment and cancer detection. This project will provide researchers with access to state-of-the-art THz spectroscopy and ....An advanced multimodal terahertz spectroscopy and imaging system for WA. An advanced multimodal terahertz spectroscopy and imaging system: Terahertz (THz) technology is in use in diverse applications from semiconductor inspection, metamaterials, biology and protein analysis, pharmaceutical sciences and formulations; security and surveillance, and biomedical imaging for burn assessment and cancer detection. This project will provide researchers with access to state-of-the-art THz spectroscopy and imaging facilities, resulting in high-impact outcomes across the physical and biological sciences and engineering, broadly contributing to Australia's economic and social well being.Read moreRead less
Bioengineered bioscaffolds for Achilles tendinopathy treatment. The purpose of the project is to improve outcomes following the surgical treatment of Achilles tendinopathy. The expected outcome is the development in animals of new ways to design tissue engineered bioscaffolds for the surgical repair of Achilles tendinopathy.
Automated texture selection and classification methods for detection of osteoarthritis in knee radiographs. In Australia there are 1-2 million OA sufferers, a condition that costs approximately $9 billion annually. This project will address an important problem of early detection and monitoring of OA and this remains in line with the National Research Priority 2. Potential outcomes of the project will result in better diagnosis and treatment of OA, reduced discomfort to the individual and saving ....Automated texture selection and classification methods for detection of osteoarthritis in knee radiographs. In Australia there are 1-2 million OA sufferers, a condition that costs approximately $9 billion annually. This project will address an important problem of early detection and monitoring of OA and this remains in line with the National Research Priority 2. Potential outcomes of the project will result in better diagnosis and treatment of OA, reduced discomfort to the individual and saving to the national economy. This project will improve existing activity and rehabilitation programs such as exercise of lower limbs and it will help in developing diets for healthy people and OA sufferers.Read moreRead less
Bone regulation - cell interactions to disease. Many bone disorders such as osteoporosis, Paget's disease and chancer related bone diseases are directly related to disruption of communication pathways between bone cells leading to imbalances in bone remodeling. Although these disorders are common and cause considerable suffering, in most cases little is known about the mechanisms responsible for dysfunctional remodeling. Understanding the communication network between bone cells and their inter ....Bone regulation - cell interactions to disease. Many bone disorders such as osteoporosis, Paget's disease and chancer related bone diseases are directly related to disruption of communication pathways between bone cells leading to imbalances in bone remodeling. Although these disorders are common and cause considerable suffering, in most cases little is known about the mechanisms responsible for dysfunctional remodeling. Understanding the communication network between bone cells and their interaction with drugs is essential in order to develop new therapies and to effectively design novel biological compatible bone implants. This research proposal closely aligns with national research priority two, i.e., promoting and maintaining good health (ageing well, ageing productively).Read moreRead less
Engineering cartilage homeostasis in health and disease. Arthritis is a common, painful and often debilitating disease affecting 16% of the Australian population and costing this community $11 billion every year. It is not well understood why cartilage degenerates into joint disease, nor how it may be reversed - partly due to the large number of mechanisms involved. This project aims to overcome this complexity by developing a computational model of cartilage that can integrate the various mech ....Engineering cartilage homeostasis in health and disease. Arthritis is a common, painful and often debilitating disease affecting 16% of the Australian population and costing this community $11 billion every year. It is not well understood why cartilage degenerates into joint disease, nor how it may be reversed - partly due to the large number of mechanisms involved. This project aims to overcome this complexity by developing a computational model of cartilage that can integrate the various mechanisms of cartilage degradation. New experiments will be used to validate the model and test predictions. The model developed will provide fundamental insights into what is required for the maintenance of healthy cartilage, and what happens in injury-induced degradation of cartilage.Read moreRead less
Magnetic Nanoparticles for Biomedical Applications. This project will develop biocompatible magnetic nanoparticles for future generations of therapeutic and diagnostic applications. Applications include the reduction in overall toxicity of chemo- and radio- therapy by magnetic target drug delivery, enhanced ability to detect and diagnose diseases using magnetic binding/sorting techniques and an enhanced ability to repair detached retinas. The development of these products provides the potential ....Magnetic Nanoparticles for Biomedical Applications. This project will develop biocompatible magnetic nanoparticles for future generations of therapeutic and diagnostic applications. Applications include the reduction in overall toxicity of chemo- and radio- therapy by magnetic target drug delivery, enhanced ability to detect and diagnose diseases using magnetic binding/sorting techniques and an enhanced ability to repair detached retinas. The development of these products provides the potential for the development of new commercial opportunities in biotechnology and biomedical science in which Australia has an excellent track record. The project will also enhance Australia's capabilities in both nanotechnologiocal and biotechnological sciences.Read moreRead less
Techniques for probing biological media with holographic angular scattering spectroscopy. Huge effort in the biological and medical sciences is spent in using simple software to laboriously mark, count and measure cells and structures in microscope images of samples. We could replace this incredibly inefficient process in many instances with single-shot size-map images of unstained samples. If depth selectivity can be added, we could perform non-invasive measurements on animals, making a huge re ....Techniques for probing biological media with holographic angular scattering spectroscopy. Huge effort in the biological and medical sciences is spent in using simple software to laboriously mark, count and measure cells and structures in microscope images of samples. We could replace this incredibly inefficient process in many instances with single-shot size-map images of unstained samples. If depth selectivity can be added, we could perform non-invasive measurements on animals, making a huge reduction in their usage. We could assess thick tissues enabling early noninvasive diagnosis of malignancy in tumours in situ or muscle characterization for meat quality or muscular dystrophy. These benefits impact on research, animal ethics, and on health, and have commercial potential in life and medical sciences, and the meat industry.Read moreRead less
Coherent optical tissue biopsy and analysis targeting muscle pathology. This international, interdisciplinary collaborative research should change the way structures in tissues are characterised with broad impact on health, biotechnology, and the meat industry. Specific benefits include: a large reduction in the time/effort required for the ubiquitous process of histology of muscle and other tissue sections and samples; a large reduction in the number of animals required in experimentation and ....Coherent optical tissue biopsy and analysis targeting muscle pathology. This international, interdisciplinary collaborative research should change the way structures in tissues are characterised with broad impact on health, biotechnology, and the meat industry. Specific benefits include: a large reduction in the time/effort required for the ubiquitous process of histology of muscle and other tissue sections and samples; a large reduction in the number of animals required in experimentation and the possibility of time sequential studies of the same animal; and in muscular dystrophy in humans, a new capability in the direct assessment of muscle tissue and the disease treatment and progression. This suite of advances should generate intellectual property of major commercial importance.Read moreRead less
High-resolution elastography – Using optical micro-imaging of tissue mechanics to identify disease. Optical elastography, the probing of tissue’s micro-mechanical properties using optical imaging, offers new tools in surgery and pathology to improve differentiation of tissues. This project lays the groundwork for optical elastography to become a new medical micro-imaging modality by removing impediments to progress in this rapidly emerging field. On the micro-scale, between the scales of cells a ....High-resolution elastography – Using optical micro-imaging of tissue mechanics to identify disease. Optical elastography, the probing of tissue’s micro-mechanical properties using optical imaging, offers new tools in surgery and pathology to improve differentiation of tissues. This project lays the groundwork for optical elastography to become a new medical micro-imaging modality by removing impediments to progress in this rapidly emerging field. On the micro-scale, between the scales of cells and organs. This project will elucidate the origins of tissue mechanical contrast and determine limits on its measurement. It will develop a suite of probes: noncontact, endoscopic and needle, to enable access to all tissues in the body. To progress toward a new modality and inform our research, the project will test our tools on breast cancer tissues and burn scars.Read moreRead less