Quantitative micro-computed tomography for mechanobiological measurement. This project aims to investigate novel measurement approaches for complex cartilage and joint systems by utilising engineering and software design, imaging physics and musculoskeletal biology. Accurate measurement of these living biological systems in action expects to generate new knowledge and a fundamental understanding of their mechanobiological processes. This project will enhance understanding of this complex system ....Quantitative micro-computed tomography for mechanobiological measurement. This project aims to investigate novel measurement approaches for complex cartilage and joint systems by utilising engineering and software design, imaging physics and musculoskeletal biology. Accurate measurement of these living biological systems in action expects to generate new knowledge and a fundamental understanding of their mechanobiological processes. This project will enhance understanding of this complex system and facilitate our capacity to innovate functional solutions in biomedical engineering and biosciences.Read moreRead less
Combined optical and electrical stimulation of auditory neurons. The bionic ear, which has now helped to improve the hearing of over 200,000 people worldwide, is a great example of Australian innovation success. This project aims to develop the fundamental technology that will underpin the next generation of these devices using a combination of infrared light and electrical signals to stimulate auditory nerves.
Discovery Early Career Researcher Award - Grant ID: DE200100909
Funder
Australian Research Council
Funding Amount
$425,523.00
Summary
3D micro-bioprinting: acoustic actuation to shape single-cell organization. This project aims to develop an innovative cell-printing technology to replicate the microscale cell structure found in native human and animal tissues. This is based on an interdisciplinary concept that combines ultra-high frequency acoustic cell manipulation with 3D stereolithography printing, and will examine acoustic waveguide element design and their topological optimisation. In contrast to current 3D printing metho ....3D micro-bioprinting: acoustic actuation to shape single-cell organization. This project aims to develop an innovative cell-printing technology to replicate the microscale cell structure found in native human and animal tissues. This is based on an interdisciplinary concept that combines ultra-high frequency acoustic cell manipulation with 3D stereolithography printing, and will examine acoustic waveguide element design and their topological optimisation. In contrast to current 3D printing methods that are not suitable for precisely integrating microscale elements in the printing process, this work will open up the range of materials, including functional human tissues, that can be printed.Read moreRead less
Complete blood fractionation using a low-cost microfluidic system. This project aims to understand particle focusing in inertial microfluidic systems to design efficient devices for cell sorting. The field of microfluidics could ultimately advance medical research but device design is primitive. Microfluidic particle separations are not thoroughly simulated before fabrication to predict performance. This project is expected to accelerate progress in design of efficient microfluidic devices. The ....Complete blood fractionation using a low-cost microfluidic system. This project aims to understand particle focusing in inertial microfluidic systems to design efficient devices for cell sorting. The field of microfluidics could ultimately advance medical research but device design is primitive. Microfluidic particle separations are not thoroughly simulated before fabrication to predict performance. This project is expected to accelerate progress in design of efficient microfluidic devices. The knowledge and models developed in this project should help design and develop a microfluidic device for efficient fractionation of complex fluids into valuable components.Read moreRead less
Non-invasive and safe human-machine interface (HMI) systems . This project aims to establish novel non-invasive human-machine interface systems based on multi-modal sensing and machine learning to intuitively command and control robotic and autonomous systems safely interacting and cooperating with humans. This will be achieved by harnessing the synergies across design optimisation, multi-modal sensing, additive manufacturing, machine learning, and assistive and cooperative robotic devices. Expe ....Non-invasive and safe human-machine interface (HMI) systems . This project aims to establish novel non-invasive human-machine interface systems based on multi-modal sensing and machine learning to intuitively command and control robotic and autonomous systems safely interacting and cooperating with humans. This will be achieved by harnessing the synergies across design optimisation, multi-modal sensing, additive manufacturing, machine learning, and assistive and cooperative robotic devices. Expected outcomes are a novel human-machine interface methodology, a new multi-purpose wearable data glove, and function and application-specific machine learning methods for cutting-edge applications in assistive robotic devices such as a prosthetic hand, advanced manufacturing, construction and agriculture.Read moreRead less
New entropy measures of short term signals for smart wearable devices. This project aims to improve reliability and accuracy of wearable devices by developing a new set of computationally efficient algorithms. Wearable devices can be very effective in remote and continuous monitoring to detect short or bursty anomalous events. Present devices are unable to detect such events effectively due to limited capability in processing short length signal. This project will provide computationally efficie ....New entropy measures of short term signals for smart wearable devices. This project aims to improve reliability and accuracy of wearable devices by developing a new set of computationally efficient algorithms. Wearable devices can be very effective in remote and continuous monitoring to detect short or bursty anomalous events. Present devices are unable to detect such events effectively due to limited capability in processing short length signal. This project will provide computationally efficient algorithms for signal quality analysis and enhanced feature extraction methods in resource constrained wearable devices. This will improve the reliability and performance of wearable devices for adoption in intelligent decision-making systems.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100241
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Seeing deeply inside the body with the world's smallest microscope. This project aims to develop the world's smallest in vivo microscope that can image the interior of living organisms at a subcellular resolution in a minimally invasive way. The project will shrink an entire microscope to the size of an optical fibre – as thin as a single strand of hair – and image deep regions of the central nervous system. This is expected to improve diagnostic tools and the knowledge of degenerative brain dis ....Seeing deeply inside the body with the world's smallest microscope. This project aims to develop the world's smallest in vivo microscope that can image the interior of living organisms at a subcellular resolution in a minimally invasive way. The project will shrink an entire microscope to the size of an optical fibre – as thin as a single strand of hair – and image deep regions of the central nervous system. This is expected to improve diagnostic tools and the knowledge of degenerative brain diseases, including Alzheimer's disease and amyotrophic lateral sclerosis. This project aims to completely transform the landscape of biomedical research and industry, with expected discoveries revolutionising the diagnosis and treatment of brain conditions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100009
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Spatial, spectral and temporal imaging through multimode optical fibre. This project aims to develop technologies for imaging through a multimode fibre that controls and measures each property of light; amplitude, phase, polarisation, wavelength and space as it propagates through an optical fibre. This will be pursued through the development of three prototype systems, where each system targets a particular property of light. The outcomes would ultimately enable multimode fibres to act as ultrac ....Spatial, spectral and temporal imaging through multimode optical fibre. This project aims to develop technologies for imaging through a multimode fibre that controls and measures each property of light; amplitude, phase, polarisation, wavelength and space as it propagates through an optical fibre. This will be pursued through the development of three prototype systems, where each system targets a particular property of light. The outcomes would ultimately enable multimode fibres to act as ultracompact, general-purpose optical conduits into the body through which a wide array of biomedical techniques can be performed in a minimally invasive fashion not currently possible. This project will provide significant benefit to the study of fundamental phenomena in optical fibres.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100302
Funder
Australian Research Council
Funding Amount
$461,300.00
Summary
A long-lasting interface for communicating with the brain. This project aims to address the most urgent challenges in developing the next generation of implantable devices for communicating with the brain. Using a new type of carbon-based electrode, along with light therapy, this project expects to build innovative technologies that can greatly enhance the functionality and longevity of these devices. Expected outcomes include a novel tool that can be implemented to obtain detailed insights into ....A long-lasting interface for communicating with the brain. This project aims to address the most urgent challenges in developing the next generation of implantable devices for communicating with the brain. Using a new type of carbon-based electrode, along with light therapy, this project expects to build innovative technologies that can greatly enhance the functionality and longevity of these devices. Expected outcomes include a novel tool that can be implemented to obtain detailed insights into neural circuits, advancing our understanding of neural function and pioneering feedback and closed-loop neuroscience. This project should provide significant benefits in neuroscience research and the neural interface industry, both of which have the ultimate goal to unlock the mysteries of the brain.Read moreRead less
Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technologica ....Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technological potential as commercially relevant research tools.Read moreRead less