Development of an implantable blood flow and pressure monitor for pulmonary hypertension. The aim is to develop an implantable device for continuous measurement of blood pressure and flow rate in the pulmonary artery. The device is to store data and download it on request to an external device. Development steps include design of the sensor lead incorporating impedance electrodes and a pressure transducer, numerical modelling of the electrode system, characterising pressure and flow waveforms f ....Development of an implantable blood flow and pressure monitor for pulmonary hypertension. The aim is to develop an implantable device for continuous measurement of blood pressure and flow rate in the pulmonary artery. The device is to store data and download it on request to an external device. Development steps include design of the sensor lead incorporating impedance electrodes and a pressure transducer, numerical modelling of the electrode system, characterising pressure and flow waveforms for condensed storage, establishing flow sensor and blood flow relationships and assessment of sensor stability and calibration demands. The device will facilitate research in pulmonary hypertension and may lead to clinical devices for monitoring effectiveness of treatment.Read moreRead less
A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100006
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
An adaptable and dedicated linear accelerator for medical radiation research. Leading radiation scientists developing innovative methods and devices for treating cancer patients will collaborate in future research using this highly adaptable linear accelerator for medical radiation research. Innovations in tumour targeting, better patient safety, new medical devices and improved cancer outcomes are expected.
Micro-electrofluidic platforms for monitoring 3D human biological models. The ability to study living cells and human biological models (cell cultures) delivers greater understanding of basic biological function and response to applied (bio)chemical stimuli. Creating the physical environments to sustain biological models, and mimic natural conditions and fluidic pathways, is immensely challenging, yet essential to deliver meaningful observational data. This project will deliver this capability t ....Micro-electrofluidic platforms for monitoring 3D human biological models. The ability to study living cells and human biological models (cell cultures) delivers greater understanding of basic biological function and response to applied (bio)chemical stimuli. Creating the physical environments to sustain biological models, and mimic natural conditions and fluidic pathways, is immensely challenging, yet essential to deliver meaningful observational data. This project will deliver this capability through the convergence of expertise and innovation in analytical chemistry, materials science and cellular biology, ultilising the latest technology and understanding of 3D micro/electrofluidics, to enable the study and stimulation of advanced biological models, sustained within precisely controlled 3D micro-environments.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less
Performance and design optimisation of oscillating water column ocean wave energy converters. This project will develop an optimised design for ocean wave energy extraction devices, known as oscillating water columns. This will significantly reduce energy conversion losses from oscillating water columns and contribute towards making them internationally competitive with other renewable energy technologies.
Predictive cost and maintenance models for bidding and short term scheduling strategies in hydro power plants. The aim of this project is to develop knowledge based models that can be used to estimate the costs implicit in operating hydro-electric power generation systems in intermittent and off-design modes. These costs manifest in increased maintenance, loss of water supply and opportunity costs or values. A model of the Tasmanian system would be unique, and the application of knowledge based ....Predictive cost and maintenance models for bidding and short term scheduling strategies in hydro power plants. The aim of this project is to develop knowledge based models that can be used to estimate the costs implicit in operating hydro-electric power generation systems in intermittent and off-design modes. These costs manifest in increased maintenance, loss of water supply and opportunity costs or values. A model of the Tasmanian system would be unique, and the application of knowledge based systems to cost and decision making in this situation is novel. Opportunities exist to collaborate with Norwegian researchers. The success of the project will lead to better utilization of the Tasmanian renewable energy resource.Read moreRead less
Optimisation of Road Network Maintenance Strategies for Life-Cycle Costs. The future of Tasmania and the nation as a competitive force in the international market is intimately linked to its transportation infrastructure network. The successful maintenance and performance of the road component is essential for an efficient and integrated system and minimisation of freight costs. The research proposes to develop a less empirical and phenomenological method of predicting the future performance of ....Optimisation of Road Network Maintenance Strategies for Life-Cycle Costs. The future of Tasmania and the nation as a competitive force in the international market is intimately linked to its transportation infrastructure network. The successful maintenance and performance of the road component is essential for an efficient and integrated system and minimisation of freight costs. The research proposes to develop a less empirical and phenomenological method of predicting the future performance of pavements, based on optimisation of maintenance strategies, by incorporating the use of probabilistic methods and Geographical Information Systems (GIS) into new Whole of Life Costing (WOLC) models.Read moreRead less
The pull-out capacity of a newly developed grouted soil nailing system. The project aims to develop a new reliable and efficient grouted soil nail system for improving the performance of loose soft soils. Important applications of the research include the mitigation of landslides, which pose a major threat to communities and infrastructure worldwide. Laboratory small scale experiments and numerical analyses will be carried out to optimize the grouting efficiency and enhance the pull-out resistan ....The pull-out capacity of a newly developed grouted soil nailing system. The project aims to develop a new reliable and efficient grouted soil nail system for improving the performance of loose soft soils. Important applications of the research include the mitigation of landslides, which pose a major threat to communities and infrastructure worldwide. Laboratory small scale experiments and numerical analyses will be carried out to optimize the grouting efficiency and enhance the pull-out resistance between the grout and surrounded soil in the soil nail system. This integrated project will provide a valuable tool for engineers who wish to stabilize loose fill slopes or soft grounds in Australia and worldwide.Read moreRead less