Properties of nanomaterials determine their disposal by liver cells. This project aims to understand how the liver handles and is affected by nanomaterials in the body. Nanomaterials are widely used in industrial, environmental, consumer and drug products, but how they affect human health is poorly understood. This project will characterise the spatiotemporal distribution of a set of nanomaterials with defined attributes in naïve and modified livers using chemistry, imaging and biological method ....Properties of nanomaterials determine their disposal by liver cells. This project aims to understand how the liver handles and is affected by nanomaterials in the body. Nanomaterials are widely used in industrial, environmental, consumer and drug products, but how they affect human health is poorly understood. This project will characterise the spatiotemporal distribution of a set of nanomaterials with defined attributes in naïve and modified livers using chemistry, imaging and biological methods. This work is expected to determine how nanomaterials’ attributes direct pathways for liver cell disposal and describe nanomaterial–liver interactions at the cellular level, information crucial in enabling safer nanomaterials for use in products such as drug formulations, sunscreens and cosmetics.Read moreRead less
Engineering layered double hydroxide nanoparticles toward an efficient targeted clinical delivery system. This project will develop a more effective drug delivery system using clay nanoparticles and biofriendly serum proteins. Outcomes from this project will provide a tremendous opportunity for potent therapies of cancers, vasculature and neuronal diseases, and place Australia at the forefront of nanotechnology drug delivery research.
A New Platform of Bio-inspired Nanoparticles for Enhanced Cellular Delivery. Delivery of various molecules into cells is crucial in modern medicine. Compared to viral vectors, non-viral vectors are safer delivery vehicles, but their delivery efficiency must be improved before they can be broadly used. Inspired by the surface topography of viruses with high infectivity, this project aims to provide a fundamental understanding of the impact of surface roughness on cellular delivery efficiency; and ....A New Platform of Bio-inspired Nanoparticles for Enhanced Cellular Delivery. Delivery of various molecules into cells is crucial in modern medicine. Compared to viral vectors, non-viral vectors are safer delivery vehicles, but their delivery efficiency must be improved before they can be broadly used. Inspired by the surface topography of viruses with high infectivity, this project aims to provide a fundamental understanding of the impact of surface roughness on cellular delivery efficiency; and to use this knowledge in the designed synthesis of a new family of bio-inspired non-viral nanoparticles with both safety and high cellular delivery efficiency. The new and high performance nano-carriers will become a platform technology with broad bio-applications in gene therapy, cancer therapy and bio-imaging.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100839
Funder
Australian Research Council
Funding Amount
$442,162.00
Summary
Nanoarchitectured platform technology for molecular profiling of exosomes. The aim of this project is to develop a set of cutting-edge nanotechnologies and a nanofabrication strategy to create a highly sensitive platform technology for exosome and exosomal miRNA analysis. This project aims to generate new knowledge in mesoporus nanomaterials and transudcer as well as exosome chemistry by developing nanostructure-based platform technology (device) for automated and rapid analysis. This project's ....Nanoarchitectured platform technology for molecular profiling of exosomes. The aim of this project is to develop a set of cutting-edge nanotechnologies and a nanofabrication strategy to create a highly sensitive platform technology for exosome and exosomal miRNA analysis. This project aims to generate new knowledge in mesoporus nanomaterials and transudcer as well as exosome chemistry by developing nanostructure-based platform technology (device) for automated and rapid analysis. This project's findings are expected to provide Australia with cutting-edge expertise for developing a next-generation platform technology for analysing exosomes and other relevant biomolecules, with the potential to deliver valuable intellectual property of commercial interest and economic benefit through technological advancements.Read moreRead less
Structure of Epitaxial Semiconductor Quantum Dots. Epitaxially grown semiconductor quantum dots have received extensive attention in recent years due to their potential applications in electronic and optoelectronic devises. However, the quality of current grown quantum dots is still very far from that required for real device applications due to a lack of detailed knowledge of their nanostructures. This project aims to combine the strength of growing semiconductor quantum dots at Fudan Universit ....Structure of Epitaxial Semiconductor Quantum Dots. Epitaxially grown semiconductor quantum dots have received extensive attention in recent years due to their potential applications in electronic and optoelectronic devises. However, the quality of current grown quantum dots is still very far from that required for real device applications due to a lack of detailed knowledge of their nanostructures. This project aims to combine the strength of growing semiconductor quantum dots at Fudan University and the world-class characterisation facilities (advanced transmission electron microscopy) at the University of Queensland to actively explore optimum paths for epaxially growing device-quality semiconductor quantum dots.Read moreRead less
Efficient Dye-Sensitised Solar Cells: New Cathodic Materials and Systems. Accelerating the uptake of renewable energy through new and diverse sources is critical to Australia's commitment to sustainable future, and Australia's energy security. This project will address key issues in commercially emerging Dye Solar Cell (DSC) technology, which has been accepted as a credible avenue to cost effective solar electricity. To date, significant development both in industry and Academia, has resulted in ....Efficient Dye-Sensitised Solar Cells: New Cathodic Materials and Systems. Accelerating the uptake of renewable energy through new and diverse sources is critical to Australia's commitment to sustainable future, and Australia's energy security. This project will address key issues in commercially emerging Dye Solar Cell (DSC) technology, which has been accepted as a credible avenue to cost effective solar electricity. To date, significant development both in industry and Academia, has resulted in Australia's leading and often pioneering position in this field. The project will maintain and enhance this position through both scientific and commercial outcomes, including opening up new markets for flexible DSC and exporting products and technological solutions through commercial activities of the Partner Organisation.Read moreRead less
Epitaxial growth of Zn-VI/III-N nanowire-based structures for future device applications. This project, aiming for developing zinc and nitrogen epitaxial nanowires, addresses specific National Research Priorities in the areas of breakthrough science, frontier technology and advanced materials. Outcomes will significantly advance the understanding of the evolution of epitaxial nanowire structures and their demonstrated properties. This project will provide informative guidelines for designing, de ....Epitaxial growth of Zn-VI/III-N nanowire-based structures for future device applications. This project, aiming for developing zinc and nitrogen epitaxial nanowires, addresses specific National Research Priorities in the areas of breakthrough science, frontier technology and advanced materials. Outcomes will significantly advance the understanding of the evolution of epitaxial nanowire structures and their demonstrated properties. This project will provide informative guidelines for designing, developing and manufacturing nanowire-based nanostructures for future nanodevices and nanosystems, which is strategically important to Australia's emerging high-tech industries. This project will also enhance the international reputation and impact of Australian research in the internationally focused field of nanoscience and nanotechnology.Read moreRead less
Microfluidic Studies of Stimuli-Responsive Emulsions. Breakthrough 'stimuli-responsive interface technology' has been developed in Australia to allow better control over emulsions, which are oil-in-water mixtures used widely in everyday products such as medicines. This project will increase our understanding of this new technology, by examining how the chemistry of the molecules at the interface interacts with fluid behaviour when the emulsion is made. The research will employ miniature lab-on-a ....Microfluidic Studies of Stimuli-Responsive Emulsions. Breakthrough 'stimuli-responsive interface technology' has been developed in Australia to allow better control over emulsions, which are oil-in-water mixtures used widely in everyday products such as medicines. This project will increase our understanding of this new technology, by examining how the chemistry of the molecules at the interface interacts with fluid behaviour when the emulsion is made. The research will employ miniature lab-on-a-chip systems, to give engineers and scientists design rules for this new technology, opening the way to new products that will improve our everyday lives. One immediate product to be researched is 'precision' double emulsions, which show unique properties for the delivery of chemotherapy medicines.Read moreRead less
Understanding the role of catalysts in the growth of epitaxial semiconductor nanowires and their hierarchical heterostructures. This Fellowship aims to comprehensively determine the role of catalysts during nanowire growth, solving the bottle-neck problem for growing device-applicable nanowires. In order to address this complicated scientific challenge, the project plans to collaborate with several world-leading researchers in different areas, such as growth, property measurements and modelling. ....Understanding the role of catalysts in the growth of epitaxial semiconductor nanowires and their hierarchical heterostructures. This Fellowship aims to comprehensively determine the role of catalysts during nanowire growth, solving the bottle-neck problem for growing device-applicable nanowires. In order to address this complicated scientific challenge, the project plans to collaborate with several world-leading researchers in different areas, such as growth, property measurements and modelling. The outcomes of this Fellowship will not only provide new science in terms of nanowire growth, but also provide guidelines for designing, developing and manufacturing nanowire-based nanostructures for future nanodevices and nanosystems. This is strategically important to place Australia at the forefront of developments on nanoscience and nanotechnology.Read moreRead less
Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this ....Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this project include a new fundamental understanding of the effect of mechanical properties on cell function, novel insights into the regulation of stem cell fate, and the development of a new class of roughness-tunable materials suitable for use in tissue engineering and pharmaceutical applications. Read moreRead less