Testing the ghost with the machine: Empirical investigations of cognition using high-field functional magnetic resonance imaging. The primary aim of the project is to test hypotheses about the cognitive architecture of word production and negative priming using high-field functional magnetic resonance imaging (fMRI). Additional aims/outcomes are to apply a novel fMRI acquisition sequence that permits overt verbal responding with rapid presentation of trials and collection of the time course of t ....Testing the ghost with the machine: Empirical investigations of cognition using high-field functional magnetic resonance imaging. The primary aim of the project is to test hypotheses about the cognitive architecture of word production and negative priming using high-field functional magnetic resonance imaging (fMRI). Additional aims/outcomes are to apply a novel fMRI acquisition sequence that permits overt verbal responding with rapid presentation of trials and collection of the time course of the blood oxygen level dependent (BOLD) signal, and to further develop a methodology that delineates the logic of making inferences about cognitive systems from functional neuroimaging data. These represent potentially significant developments in the fields of cognitive neuroscience and functional neuroimaging.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100741
Funder
Australian Research Council
Funding Amount
$342,996.00
Summary
Harnessing neural plasticity with brain stimulation. This project aims to investigate the links between the molecular mechanisms underlying brain plasticity and the effects of non-invasive brain stimulation. It will use a novel approach that integrates genetics, electrophysiology and biological modelling. Plasticity underpins all learning, memory and aging. Brain stimulation can drive plasticity in humans, but these effects are extremely difficult to harness and vary widely between people. Expec ....Harnessing neural plasticity with brain stimulation. This project aims to investigate the links between the molecular mechanisms underlying brain plasticity and the effects of non-invasive brain stimulation. It will use a novel approach that integrates genetics, electrophysiology and biological modelling. Plasticity underpins all learning, memory and aging. Brain stimulation can drive plasticity in humans, but these effects are extremely difficult to harness and vary widely between people. Expected outcomes include a critical understanding of the fundamental mechanisms governing plasticity. This will provide significant benefits such as the development of individually optimised brain stimulation protocols, enabling tailored, reliable approaches to address brain function and cognition.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100694
Funder
Australian Research Council
Funding Amount
$372,014.00
Summary
Does disconnection in the aging brain cause age-related movement decline? This project aims to use new neurophysiological approaches to understand the causal role of age-related changes in brain network connectivity to the movement control. Brain regions interact through complex and dynamic neural networks to control voluntary movement, but whether age-related changes in network connectivity drive age-related decline in movement control is unknown. This project will provide significant benefits ....Does disconnection in the aging brain cause age-related movement decline? This project aims to use new neurophysiological approaches to understand the causal role of age-related changes in brain network connectivity to the movement control. Brain regions interact through complex and dynamic neural networks to control voluntary movement, but whether age-related changes in network connectivity drive age-related decline in movement control is unknown. This project will provide significant benefits such as the neurophysiological knowledge required to develop targeted interventions to improve movement control in the aging population.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100575
Funder
Australian Research Council
Funding Amount
$423,604.00
Summary
Does neuroplasticity protect against late life cognitive impairment? This project aims to investigate neuroplasticity across the adult lifespan, using novel neurophysiological approaches to determine its role in protecting against age-related cognitive decline. This project expects to generate new knowledge in the area of human cognitive ageing, using an innovative and interdisciplinary approach. Expected outcomes of this project include a critical understanding of the basic neural mechanisms of ....Does neuroplasticity protect against late life cognitive impairment? This project aims to investigate neuroplasticity across the adult lifespan, using novel neurophysiological approaches to determine its role in protecting against age-related cognitive decline. This project expects to generate new knowledge in the area of human cognitive ageing, using an innovative and interdisciplinary approach. Expected outcomes of this project include a critical understanding of the basic neural mechanisms of healthy brain ageing. This will provide significant benefits, such as the neurophysiological knowledge required to develop novel biological markers to detect, as well as therapeutic agents to curb, cognitive decline in the aging population.Read moreRead less
Understanding working memory: from cells to brain stimulation. This project aims to understand the neural mechanisms of working memory, a fundamental cognitive function in humans, using a novel framework which combines non-invasive brain stimulation, neuroimaging, pharmacological and experimental manipulations, and biological modelling. Expected outcomes include a critical understanding of the cellular mechanisms underlying both neural activity and working memory ability in healthy individuals a ....Understanding working memory: from cells to brain stimulation. This project aims to understand the neural mechanisms of working memory, a fundamental cognitive function in humans, using a novel framework which combines non-invasive brain stimulation, neuroimaging, pharmacological and experimental manipulations, and biological modelling. Expected outcomes include a critical understanding of the cellular mechanisms underlying both neural activity and working memory ability in healthy individuals and a detailed knowledge of how to non-invasively interact with these mechanisms using brain stimulation. This will provide significant benefits such as the development of individually optimised brain stimulation protocols, enabling tailored approaches to reliably alter brain function and cognition.Read moreRead less
Testing posterior parietal cortex contributions to human episodic memory. This project aims to determine the involvement of parietal brain regions for episodic memory. Using novel experimental tasks and multimodal neuroimaging techniques in young and healthy aging, this project expects to clarify the role of posterior parietal structures, and their interactions with core memory structures, during memory retrieval. Expected outcomes include advanced understanding of how we remember the past in ri ....Testing posterior parietal cortex contributions to human episodic memory. This project aims to determine the involvement of parietal brain regions for episodic memory. Using novel experimental tasks and multimodal neuroimaging techniques in young and healthy aging, this project expects to clarify the role of posterior parietal structures, and their interactions with core memory structures, during memory retrieval. Expected outcomes include advanced understanding of how we remember the past in rich contextual detail, and how such processes are altered in healthy aging. This potentially provides significant benefits in predicting and treating memory dysfunction due to brain injury or neurodegeneration.Read moreRead less
Human hippocampus subregions organisation and associative memory processes. This proposal will investigate the hippocampus, a highly inter-connected structure containing many subregions. Although considered the memory centre of the brain, we still do not know the exact roles of these subregions during memory processes. Using novel brain neuroimaging acquisition methods and analyses, this project aims to map the internal structure and functions of the hippocampus and its functional networks under ....Human hippocampus subregions organisation and associative memory processes. This proposal will investigate the hippocampus, a highly inter-connected structure containing many subregions. Although considered the memory centre of the brain, we still do not know the exact roles of these subregions during memory processes. Using novel brain neuroimaging acquisition methods and analyses, this project aims to map the internal structure and functions of the hippocampus and its functional networks under different memory conditions and how these functions change with age. The intended outcome of this proposal is to provide the foundations for the first integrated model of human memory and its biological basis and to generate a benchmark against which future development of memory interventions and retraining can be measured.Read moreRead less
Charting age-related changes in the quality of episodic memory. As we get older, our capacity to remember events in rich detail becomes less efficient. The mechanisms driving these changes remain unclear, severely limiting our capacity to accurately assess and optimise memory function in later years. This project aims to determine how memory accuracy and memory quality change across the adult lifespan using cutting-edge experimental and neuroimaging techniques. It will deliver new insights into ....Charting age-related changes in the quality of episodic memory. As we get older, our capacity to remember events in rich detail becomes less efficient. The mechanisms driving these changes remain unclear, severely limiting our capacity to accurately assess and optimise memory function in later years. This project aims to determine how memory accuracy and memory quality change across the adult lifespan using cutting-edge experimental and neuroimaging techniques. It will deliver new insights into the relationship between confidence, memory success and memory quality, and the underlying neural substrates of these processes. This work will provide the essential empirical foundation to augment memory function, ensuring that older adults can continue to participate as active members of society.Read moreRead less
Individualised predictions of circadian timing, sleep, and performance. The body's 24-hour clock regulates when we feel sleepy or alert. In shift workers, disrupted sleep and rhythms leads to fatigue and costly, often deadly, workplace accidents. Existing methods for measuring body clock timing are costly, impractical for operational settings, and do not work in real time. Using a shift-worker population, this project will develop models that accurately predict body timing, sleep/wake patterns, ....Individualised predictions of circadian timing, sleep, and performance. The body's 24-hour clock regulates when we feel sleepy or alert. In shift workers, disrupted sleep and rhythms leads to fatigue and costly, often deadly, workplace accidents. Existing methods for measuring body clock timing are costly, impractical for operational settings, and do not work in real time. Using a shift-worker population, this project will develop models that accurately predict body timing, sleep/wake patterns, and performance for an individual, requiring only a simple activity/light sensor and an assessment of the body clock's sensitivity to light. The new model would revolutionise fatigue management and make safer work environments for millions of shift workers. Read moreRead less
Neural circuitry of maternal behaviour. Elaborate maternal care is a defining characteristic of mammalian species, suggesting conserved brain pathways evolved to orchestrate these responses. The neural substrates underscoring maternal behaviour have not been fully elucidated. This project aims to investigate the brain circuitry underpinning maternal care using a multidisciplinary approach combining behavioural assays and pharmacogenetic manipulations in mice alongside sophisticated molecular and ....Neural circuitry of maternal behaviour. Elaborate maternal care is a defining characteristic of mammalian species, suggesting conserved brain pathways evolved to orchestrate these responses. The neural substrates underscoring maternal behaviour have not been fully elucidated. This project aims to investigate the brain circuitry underpinning maternal care using a multidisciplinary approach combining behavioural assays and pharmacogenetic manipulations in mice alongside sophisticated molecular and functional analyses. The outcomes of this project are expected to improve our understanding of how specific brain pathways govern maternal behaviour. The novel insight gained is expected to advance theories regarding the organisation of maternal care and enable their practical testing.Read moreRead less