Rational Design of Pegylated Dendrimer Nanostructures for Site Specific Drug Delivery. This project will provide technological advances with significant benefits in terms of improved drug treatment, and therefore health outcomes for Australia. The project builds on areas of research strength in Australia (nanotechnology and biotechnology/biomaterials) and will add considerably to the expanding Australian expertise-base in dendrimer technology (in which it is a world leader). The interdisciplinar ....Rational Design of Pegylated Dendrimer Nanostructures for Site Specific Drug Delivery. This project will provide technological advances with significant benefits in terms of improved drug treatment, and therefore health outcomes for Australia. The project builds on areas of research strength in Australia (nanotechnology and biotechnology/biomaterials) and will add considerably to the expanding Australian expertise-base in dendrimer technology (in which it is a world leader). The interdisciplinary nature of this project will also result in a unique training program for the researchers included in this grant. Such experience is in great demand, particularly in Australia where the burgeoning start-up discovery industry is critically short of personnel with skills in drug delivery.Read moreRead less
Enhanced drug delivery using nanoparticulate dendrimer vectors. Many drug candidates fail during development because of low and variable absorption after oral administration. This project seeks to investigate the utility of specialised nanometer-sized macromolecules (dendrimers), to facilitate the improved delivery of drug molecules where low aqueous solubility is the principle limitation to drug absorption and will also be explored as vectors to specifically target drugs to intestinal lymphoid ....Enhanced drug delivery using nanoparticulate dendrimer vectors. Many drug candidates fail during development because of low and variable absorption after oral administration. This project seeks to investigate the utility of specialised nanometer-sized macromolecules (dendrimers), to facilitate the improved delivery of drug molecules where low aqueous solubility is the principle limitation to drug absorption and will also be explored as vectors to specifically target drugs to intestinal lymphoid (immune) tissue. This project will link the drug delivery expertise of Monash University with the experience in dendrimer design of the Australian biotechnology company Starpharma to provide concrete delivery solutions for the rapidly expanding biotechnology industry in Australia.Read moreRead less
Engineered nanostructured materials via continuous polymer assembly for advanced bioapplications. The development of new and flexible processes is critical to the design and construction of advanced materials for future applications in nano- and biotechnology. This project will develop innovative and versatile "bottom-up" nanotechnology techniques to afford nanostructured materials with unprecedented properties. This project has the potential to revolutionise current approaches for forming surfa ....Engineered nanostructured materials via continuous polymer assembly for advanced bioapplications. The development of new and flexible processes is critical to the design and construction of advanced materials for future applications in nano- and biotechnology. This project will develop innovative and versatile "bottom-up" nanotechnology techniques to afford nanostructured materials with unprecedented properties. This project has the potential to revolutionise current approaches for forming surface coatings, films and advanced particles, leading to significant outcomes in diverse areas, including drug delivery, biomaterial implants and biocatalysis. The project will contribute to the development of a robust Australian nanotechnology industry, with the advanced materials developed expected to have health benefits for Australian citizens.Read moreRead less
Building Molecularly Engineered Polymer Nanomaterials. The development of new technologies at the interface between nano- and biotechnology promises to revolutionise healthcare and medicine. This research program will involve the design and synthesis of responsive and programmable polymers and their assembly to form next-generation, engineered materials. The nanomaterials prepared are expected to lead to the development of techniques that enable new types of minimally invasive diagnostics and th ....Building Molecularly Engineered Polymer Nanomaterials. The development of new technologies at the interface between nano- and biotechnology promises to revolutionise healthcare and medicine. This research program will involve the design and synthesis of responsive and programmable polymers and their assembly to form next-generation, engineered materials. The nanomaterials prepared are expected to lead to the development of techniques that enable new types of minimally invasive diagnostics and therapeutics as well as smaller devices. The interdisciplinary research program will cement Australia's position as a leading country in nanobiotechnology research and development.Read moreRead less
Engineering and Assembly of Bioinspired Nanostructured Materials. Scientific and technological advances at the frontiers of nano- and bio-technology are poised to revolutionise healthcare and medicine. This project will involve the design, synthesis and engineering of functional biopolymer building blocks. These 'smart' biopolymers will then be assembled into responsive, nanostructured materials for targeted drug delivery and biosensing applications. These materials are expected to ultimately ha ....Engineering and Assembly of Bioinspired Nanostructured Materials. Scientific and technological advances at the frontiers of nano- and bio-technology are poised to revolutionise healthcare and medicine. This project will involve the design, synthesis and engineering of functional biopolymer building blocks. These 'smart' biopolymers will then be assembled into responsive, nanostructured materials for targeted drug delivery and biosensing applications. These materials are expected to ultimately have health benefits for Australian citizens and contribute to the development of a robust Australian nanobiotechnology industry. The project will also provide excellent opportunities for the development of outstanding young scientists and will foster exciting, multidisciplinary collaborations.Read moreRead less
Caveospheres: A versatile peptide delivery system. Nanotechnology has the potential to transform the way we treat many diseases. This project will investigate a new type of nanoparticle, the caveosphere, and tests its effectiveness as a peptide delivery system. Caveospheres can protect delicate cargo from degradation, target cargo to specific cells that induce the maximum therapeutic response, and can be synthesised in large-scale, cost-effective batch fermentation. This study will:
1: Engineer ....Caveospheres: A versatile peptide delivery system. Nanotechnology has the potential to transform the way we treat many diseases. This project will investigate a new type of nanoparticle, the caveosphere, and tests its effectiveness as a peptide delivery system. Caveospheres can protect delicate cargo from degradation, target cargo to specific cells that induce the maximum therapeutic response, and can be synthesised in large-scale, cost-effective batch fermentation. This study will:
1: Engineer biological function into caveospheres
2: Investigate the cellular behavior of the engineered caveospheres
3: Determine the therapeutic activity of caveospheres in vitro
It will develop a fundamental understanding of nanoparticles trafficking in cells, to make improved nanoparticle delivery systems.Read moreRead less
Next generation enzymes using stimuli responsive protein/polymer hybrids. Improved stability and control over activity are key to unlocking the full potential of enzymes. Advanced polymer synthesis and synthetic biology will be combined to engineer stable, bioresponsive enzyme/polymer hybrids. This study will:
1: Develop a rapid screening method to identify the optimal sites for polymer-to-enzyme attachment
2: Evaluate the stability and bioresponsive activity of enzyme/polymer hybrids
3: Formula ....Next generation enzymes using stimuli responsive protein/polymer hybrids. Improved stability and control over activity are key to unlocking the full potential of enzymes. Advanced polymer synthesis and synthetic biology will be combined to engineer stable, bioresponsive enzyme/polymer hybrids. This study will:
1: Develop a rapid screening method to identify the optimal sites for polymer-to-enzyme attachment
2: Evaluate the stability and bioresponsive activity of enzyme/polymer hybrids
3: Formulate enzyme/polymer hybrids into a targeted nanoparticle delivery system
This project will examine the performance of polymer-enzyme hybrids with cells, however these innovations will also have significant applications in other fields using enzymatic processes, such as food processing, biofuel production, and agriculture.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454008
Funder
Australian Research Council
Funding Amount
$340,962.00
Summary
Multi-function high resolution-analytical scanning electron microscope facility. The aim of this proposal is to establish a high resolution electron microscope facility as part of a comprehensive materials characterisation infrastructure required to support Swinburne's expanding activities in nanotechnology. A high resolution SEM in conjunction with an upgrade of the current SEM will provide advanced instrumentation for nanoscale imaging, analysis and manipulation of materials. The proposed faci ....Multi-function high resolution-analytical scanning electron microscope facility. The aim of this proposal is to establish a high resolution electron microscope facility as part of a comprehensive materials characterisation infrastructure required to support Swinburne's expanding activities in nanotechnology. A high resolution SEM in conjunction with an upgrade of the current SEM will provide advanced instrumentation for nanoscale imaging, analysis and manipulation of materials. The proposed facility will create new opportunities for collaborative programs with local and overseas researcher and will facilitate rapid progress in research programs across the entire University in particular those related to two ARC Centres of Excellence in which the University is a core partner.Read moreRead less
Synthesis and Functionalisation of Advanced Polymer Films and Particles. Scientific and technological advances at the frontiers of nano- and biotechnology are poised to revolutionise the scope of treatment and healthcare options. This project will involve the synthesis of engineered polymer building blocks with the capability for multifunctional and intelligent response. These smart polymers will then be assembled into responsive nanostructured materials for drug delivery and biosensing applica ....Synthesis and Functionalisation of Advanced Polymer Films and Particles. Scientific and technological advances at the frontiers of nano- and biotechnology are poised to revolutionise the scope of treatment and healthcare options. This project will involve the synthesis of engineered polymer building blocks with the capability for multifunctional and intelligent response. These smart polymers will then be assembled into responsive nanostructured materials for drug delivery and biosensing applications. These materials are expected to have health benefits for Australian citizens and will contribute to a world-leading nanobiotechnology industry. The project will also provide development opportunities for young scientists and will also foster multidisciplinary collaborations within both Australia and abroad.Read moreRead less
Special Research Initiatives - Grant ID: SR0354775
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian Synchrotron Sciences Network. A synchrotron light source is a critical piece of infrastructure for a modern technological nation. In 2001, the Victorian government announced that it would contribute $157M towards the establishment of a national synchrotron facility, becoming operational in 2007. The research performed at such a facility is exceedingly diverse, and often the underpinning technology is the only point of contact for users. A vibrant and productive facility requires a tra ....Australian Synchrotron Sciences Network. A synchrotron light source is a critical piece of infrastructure for a modern technological nation. In 2001, the Victorian government announced that it would contribute $157M towards the establishment of a national synchrotron facility, becoming operational in 2007. The research performed at such a facility is exceedingly diverse, and often the underpinning technology is the only point of contact for users. A vibrant and productive facility requires a transparent interface between the scientist and the technology. This Network will set up the communication channels within the user base, and between the users and the facility development program.Read moreRead less