Who were the ancestors of Homo floresiensis? The discovery of a tiny, new hominid species living in Indonesia until just 12,000 years ago, at the same time as modern humans in the region, has sparked world-wide public interest and debate. Finding the ancestors of this species will further promote Australian research as high profile, high calibre and cutting edge. Collaboration with researchers and institutions in Indonesia, USA, Kenya, Tanzania, South Africa and the Republic of Georgia will stre ....Who were the ancestors of Homo floresiensis? The discovery of a tiny, new hominid species living in Indonesia until just 12,000 years ago, at the same time as modern humans in the region, has sparked world-wide public interest and debate. Finding the ancestors of this species will further promote Australian research as high profile, high calibre and cutting edge. Collaboration with researchers and institutions in Indonesia, USA, Kenya, Tanzania, South Africa and the Republic of Georgia will strengthen our links with these nations.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0231228
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Victorian Environmental Scanning Electron Microscopy Facility. The aim of this proposal is to establish a state-of-the-art Environmental Scanning Electron Microscope (ESEM) facility in the Melbourne region. ESEMs have considerable advantages over conventional instruments in that they allow imaging and analysis to be performed in gaseous or high pressure environments. This enables electron microscopy to be used for the detailed analysis of insulating, wet or out-gassing specimens in their natural ....Victorian Environmental Scanning Electron Microscopy Facility. The aim of this proposal is to establish a state-of-the-art Environmental Scanning Electron Microscope (ESEM) facility in the Melbourne region. ESEMs have considerable advantages over conventional instruments in that they allow imaging and analysis to be performed in gaseous or high pressure environments. This enables electron microscopy to be used for the detailed analysis of insulating, wet or out-gassing specimens in their natural state as well as the investigation, in real time, of dynamical processes such as crystallisation and corrosion. The new facility will support a wide range of multi-disciplinary research programs from four Universities and three CSIRO divisions.Read moreRead less
ARC Centre of Excellence - Coherent X-ray Science. The twenty first century is said to be the century of biology. And there is no doubt that the development of our understanding of biological system is continuing at a massive rate. However as our understanding deepens, we need to draw on the whole range of scientific disciplines to proceed. This Centre draws together a multidisciplinary team of world-leading scientists to address one the key questions in modern biology, the structure of a membra ....ARC Centre of Excellence - Coherent X-ray Science. The twenty first century is said to be the century of biology. And there is no doubt that the development of our understanding of biological system is continuing at a massive rate. However as our understanding deepens, we need to draw on the whole range of scientific disciplines to proceed. This Centre draws together a multidisciplinary team of world-leading scientists to address one the key questions in modern biology, the structure of a membrane protein. We will develop techniques based on the latest developments in theoretical physics & chemistry, imaging, biology and technology - including the new Australian Synchrotron - to create new approaches to structural biology.Read moreRead less
Mathematical Methods for Next Generation Sequencing. The emergence of a new generation of high throughput genomic sequencing technologies is providing unprecedented opportunities for biological research. Hidden within the huge amounts of data generated by this technology is information about the expression and regulation of genes, and the complex functional purpose of non-coding, so called 'junk', DNA. Development of mathematical and statistical tools is essential to interpreting these data. The ....Mathematical Methods for Next Generation Sequencing. The emergence of a new generation of high throughput genomic sequencing technologies is providing unprecedented opportunities for biological research. Hidden within the huge amounts of data generated by this technology is information about the expression and regulation of genes, and the complex functional purpose of non-coding, so called 'junk', DNA. Development of mathematical and statistical tools is essential to interpreting these data. The proposed research will enhance Australia's reputation for developing novel quantitative techniques at the cutting edge of modern biology. The proposed project has a broad range of potential applications in biotechnology, particularly in the medical and agricultural industries.Read moreRead less
Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly whe ....Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly where they act in the brain. Read moreRead less
Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly whe ....Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly where they act in the brain. Read moreRead less
Force from lipids: the role of the lipid bilayer in mechanosensory transduction. The proposed research will significantly contribute to a better understanding of the wide range of physiological processes underlying mechanosensory transduction in living cells. The direct benefit for Australian science consists of: (i) strengthening international links with leading overseas laboratories, and (ii) accessing the state-of-the-art expertise not available in Australia. The acquired knowledge will aid i ....Force from lipids: the role of the lipid bilayer in mechanosensory transduction. The proposed research will significantly contribute to a better understanding of the wide range of physiological processes underlying mechanosensory transduction in living cells. The direct benefit for Australian science consists of: (i) strengthening international links with leading overseas laboratories, and (ii) accessing the state-of-the-art expertise not available in Australia. The acquired knowledge will aid in developing and designing artificial tactile sensors inspired by their biological models studied in this project. Long-term, the project is expected to make an original contribution towards developing new technologies and novel medical applications, both of which promise to be of great national benefit.Read moreRead less
Special Research Initiatives - Grant ID: SR0354683
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Ocean Discovery Network. The ODN will focus research on Australia's vast marine jurisdiction by:
1. Providing a forum for developing coordinated marine research enterprises in the National Research Priority areas of biodiversity, exploitation of resources, seaway security and climate.
2. Developing innovative international research and providing a mechanism for involvement in international science programs
3. Advancing research capabilities between national and international ocean scientist ....Ocean Discovery Network. The ODN will focus research on Australia's vast marine jurisdiction by:
1. Providing a forum for developing coordinated marine research enterprises in the National Research Priority areas of biodiversity, exploitation of resources, seaway security and climate.
2. Developing innovative international research and providing a mechanism for involvement in international science programs
3. Advancing research capabilities between national and international ocean scientists with web-based data-exchange services and links to global databases
4. Facilitating the transfer of research skills to young investigators
5. Maximising multidisciplinary use of Australian ocean science capacity, particularly the National Facility Research Vessel and the RSV Aurora Australis
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Special Research Initiatives - Grant ID: SR0354610
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian Bioinformatics Grid Network. OzBioGrid will be an open source, collaborative, bioinformatics environment supporting Australian biotechnology and life science researchers on the Grid. Researchers will be able to use distributed resources including databases, computational power and analytical tools, and to collaborate remotely, using customized work environments. With hubs in Brisbane, Canberra and Melbourne, and nodes elsewhere, OzBioGrid will build on Australia's high performance co ....Australian Bioinformatics Grid Network. OzBioGrid will be an open source, collaborative, bioinformatics environment supporting Australian biotechnology and life science researchers on the Grid. Researchers will be able to use distributed resources including databases, computational power and analytical tools, and to collaborate remotely, using customized work environments. With hubs in Brisbane, Canberra and Melbourne, and nodes elsewhere, OzBioGrid will build on Australia's high performance computing capacity. It will greatly enhance Australia's research capability by networking ARC and other centres of excellence, major national research facilities, independent researchers, biotechnology companies, bioinformatics research centres, public databases. It will be linked to bio-grid initiatives overseas. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882289
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, ( ....New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, (ii) investigating the structure(s) of lipids (fats) in cardiovascular disease and cataract, (iii) developing anticancer drugs, and (iv) development of new materials.Read moreRead less