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Charting the human brain connectome over the lifespan. This project aims to develop neuroimaging reference charts for the human connectome and track the vast individual variability in brain connectivity across the life course. Connectomes will be mapped using tractography and diffusion magnetic resonance imaging data for 40,000 individuals, establishing the largest connectome biobank to date. Expected outcomes include an innovative lifespan brain charting platform, new paradigms to model individ ....Charting the human brain connectome over the lifespan. This project aims to develop neuroimaging reference charts for the human connectome and track the vast individual variability in brain connectivity across the life course. Connectomes will be mapped using tractography and diffusion magnetic resonance imaging data for 40,000 individuals, establishing the largest connectome biobank to date. Expected outcomes include an innovative lifespan brain charting platform, new paradigms to model individual brain variability and knowledge of how cognition, lifestyle and environment shape brain ageing. Brain charting will usher in a new era of precision connectomics, paving the way towards neuroscience-based personalisation of pathways in education, employment and wellbeing. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100177
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
A flexible high throughput analytical system for psychopharmacology and drug discovery. A sensitive new liquid chromatography mass spectrometer will enable a team of leading researchers to detect drugs of abuse and therapeutic drugs in the brain and body as well as levels of hormones, peptides and neurotransmitters. This will enhance a large number of projects examining new treatments for addictive disorders and mental illness.
RCTs on Trial: How Placebo Effects Could Undermine Double-blind RCTs. Double-blind randomised placebo-controlled trials (RCTs) are considered the gold standard for establishing treatment efficacy. However, there are both theoretical and empirical reasons to believe that they do not adequately control for the placebo effect. Cost and ethical considerations prevent researchers conducting actual double-blind RCTs with patients from exploring these issues. To address this gap, this project uses nove ....RCTs on Trial: How Placebo Effects Could Undermine Double-blind RCTs. Double-blind randomised placebo-controlled trials (RCTs) are considered the gold standard for establishing treatment efficacy. However, there are both theoretical and empirical reasons to believe that they do not adequately control for the placebo effect. Cost and ethical considerations prevent researchers conducting actual double-blind RCTs with patients from exploring these issues. To address this gap, this project uses novel experimental models to systematically test key aspects of the double-blind RCT methodology that are intended to control for the placebo effect. The project aims to provide essential data on the validity of these trials, thereby improving Australia's health and ensuring that Government treatment subsidies are well spent.Read moreRead less
Memory consolidation - Integrating cognitive science and neuroscience approaches to how we remember and how we forget. How can we forget what happened yesterday, but vividly remember our first kiss? Neuroscientists think the brain has a special mechanism to strengthen memories with time, but many psychologists disagree. The project aims to bring the brain and the mind closer together, using the cutting-edge combination of brain imaging and psychological modelling.
To focus on pain or not to focus: WHEN is the question. The experience of pain is a ubiquitous experience, and persistent pain is common and causes enormous personal and
societal burden. Anyone who has been in severe pain will understand that pain captures attention, but the role that attention plays in
increasing pain perception is poorly understood. This project will test a new conceptual model that calls for a change in the paradigm underlying research into attention and pain. We will use nov ....To focus on pain or not to focus: WHEN is the question. The experience of pain is a ubiquitous experience, and persistent pain is common and causes enormous personal and
societal burden. Anyone who has been in severe pain will understand that pain captures attention, but the role that attention plays in
increasing pain perception is poorly understood. This project will test a new conceptual model that calls for a change in the paradigm underlying research into attention and pain. We will use novel experimental tasks in virtual reality environments to address
these important gaps in our knowledge. The project will significantly advance our fundamental understanding of
the role of attention in pain perception and pave the way for translational research to reduce the substantial burden pain causes.Read moreRead less
Understanding psychological processes that inhibit the nocebo effect. The nocebo effect – when negative expectancies trigger adverse outcomes – causes enormous personal and societal harm. Although there have been advances in understanding some of the psychological processes underlying these effects, much less is known about how to inhibit them or the role that social learning plays in producing them. This project uses a new experimental model involving Galvanic Vestibular Stimulation to address ....Understanding psychological processes that inhibit the nocebo effect. The nocebo effect – when negative expectancies trigger adverse outcomes – causes enormous personal and societal harm. Although there have been advances in understanding some of the psychological processes underlying these effects, much less is known about how to inhibit them or the role that social learning plays in producing them. This project uses a new experimental model involving Galvanic Vestibular Stimulation to address these important gaps in our knowledge. The project will significantly advance our fundamental understanding of the nocebo effect and pave the way for translational research to reduce the substantial harm it causes.Read moreRead less
Placing prediction into the fear circuit. How do we predict danger in our world? This project will identify the psychological mechanisms and brain pathways that allow us to learn to fear and to also overcome fear when it becomes pathological.
Discovery Early Career Researcher Award - Grant ID: DE240100950
Funder
Australian Research Council
Funding Amount
$459,051.00
Summary
Identifying hypothalamic circuits that integrate stress and metabolism. This project aims to investigate how the brain integrates threat during hunger. Using cutting-edge technology to manipulate and record neural activity this project will elucidate the brain circuits that integrate threat and appetite to minimize stress exposure during foraging. This will expand our knowledge on how the brain perceives and responds to hunger and may provide relevant information for a large number of basic biol ....Identifying hypothalamic circuits that integrate stress and metabolism. This project aims to investigate how the brain integrates threat during hunger. Using cutting-edge technology to manipulate and record neural activity this project will elucidate the brain circuits that integrate threat and appetite to minimize stress exposure during foraging. This will expand our knowledge on how the brain perceives and responds to hunger and may provide relevant information for a large number of basic biological processes controlling the brain. Expected outcomes of this project will contribute to a better understanding of the circuitry controlling more complex decisions from food selection through to social interactions. This should provide significant benefits for Australia’s competitiveness within neuroscience research.Read moreRead less
The regulation of desire by bodily state. Many experiences, like food, wine and sex, are pleasurable. These experiences are also desired, but less so when sated. The aim of this proposal is to understand how satiation regulates desire. We propose two memory-based models, and test them using several new experimental approaches. This is significant, not only because poorly regulated desire is linked to many social and economic ills (e.g., over-eating), but also because it is a key part of huma ....The regulation of desire by bodily state. Many experiences, like food, wine and sex, are pleasurable. These experiences are also desired, but less so when sated. The aim of this proposal is to understand how satiation regulates desire. We propose two memory-based models, and test them using several new experimental approaches. This is significant, not only because poorly regulated desire is linked to many social and economic ills (e.g., over-eating), but also because it is a key part of human motivation that is poorly understood. The expected outcome is a new theoretical model of how memory processes interact with bodily signals to generate both sated states and desire. The benefits include a new understanding of how desire is regulated and how and why this might break down.Read moreRead less
Biased information processing in anxiety: Low anxiety scores, but still at risk. Information processing in anxious persons is biased if confronted with threatening stimulus materials such as words or pictures. This finding has considerable implications for our understanding of fear acquisition and maintenance and for the design of therapeutic interventions. More recent research has shown, however, that low anxious persons who employ repressive coping styles show similar biases. The present proj ....Biased information processing in anxiety: Low anxiety scores, but still at risk. Information processing in anxious persons is biased if confronted with threatening stimulus materials such as words or pictures. This finding has considerable implications for our understanding of fear acquisition and maintenance and for the design of therapeutic interventions. More recent research has shown, however, that low anxious persons who employ repressive coping styles show similar biases. The present project will follow up on these findings by combining the expertises of the two CIs in contemporary cognitive and psychophysiological research. It will not only provide new insights, but also offer research opportunities for postgraduate students, and prospects for future collaborative funding.Read moreRead less