Seeing is believing: Microscopy-capable single-molecule bioelectronics. This project aims to create new biophysical tools for single-molecule sensing by advancing the state-of-the-art in nanoscale bioelectronic devices. The goal is to generate novel bioelectronic devices optimised for fabrication on microscope coverslip (170 micron glass) for compatibility with new low-cost platforms for advanced biological microscopy. Expected outcomes include the first organic electrochemical transistors inter ....Seeing is believing: Microscopy-capable single-molecule bioelectronics. This project aims to create new biophysical tools for single-molecule sensing by advancing the state-of-the-art in nanoscale bioelectronic devices. The goal is to generate novel bioelectronic devices optimised for fabrication on microscope coverslip (170 micron glass) for compatibility with new low-cost platforms for advanced biological microscopy. Expected outcomes include the first organic electrochemical transistors interfaced to constrained area lipid bilayers for studying membrane proteins at single-molecule level and nanoscale transistors for electrostatically detecting motile microtubules in in-vitro molecular motor assays for biocomputation. The intended benefit is innovation in capabilities and manufacturing of bioelectronics.Read moreRead less
Background-free imaging of single membrane-receptors with nanophosphors. This project aims to develop nanophosphor beacons and real-time, ultrahigh-sensitivity functional imaging to provide a picture of the brain. Time-gated detection microscopy will give these nanophosphors a superior optical contrast. The nanophosphors’ antibody-targeting will image single AMPA membrane receptors in their full biological context, crucial to understanding neuronal signalling. Simultaneous imaging of receptor tr ....Background-free imaging of single membrane-receptors with nanophosphors. This project aims to develop nanophosphor beacons and real-time, ultrahigh-sensitivity functional imaging to provide a picture of the brain. Time-gated detection microscopy will give these nanophosphors a superior optical contrast. The nanophosphors’ antibody-targeting will image single AMPA membrane receptors in their full biological context, crucial to understanding neuronal signalling. Simultaneous imaging of receptor trafficking and activity in neurons will help to uncover details of the dynamic activity in the brain. This technology is expected to help understand the inner workings of the brain and provide insights into its functioning.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120100295
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Computational modelling of nanostructures designed to mimic ion-selective biological channels. The project aims to design nanotubes (hollow tubes with nanometre diameters) constructed from various materials, such as carbon, to broadly mimic biological ion channels. This research will facilitate the development of efficient desalination membranes, potent antibiotics and pharmaceutical products for treatments of cancer and cystic fibrosis.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775562
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
The Melbourne Nanofabrication Facility. Australia is desperately short of facilities for actual fabrication, prototyping and construction of advanced micromechanical and nanoscale systems. This is impeding both academic researchers and industrial developers in the materials, optics and biotechnological industries. The proposed instrument would complete the development of Australia's newest high resolution microscopy centre and enable a wide range of users to image, measure, build and design comp ....The Melbourne Nanofabrication Facility. Australia is desperately short of facilities for actual fabrication, prototyping and construction of advanced micromechanical and nanoscale systems. This is impeding both academic researchers and industrial developers in the materials, optics and biotechnological industries. The proposed instrument would complete the development of Australia's newest high resolution microscopy centre and enable a wide range of users to image, measure, build and design complex nanostructures at the atomic level and upwards. Read moreRead less
Special Research Initiatives - Grant ID: SR0354658
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
The Nanoparticle Network. Nanoscale materials are objects with one dimension less than about 20nm in size. Such exotic materials display unique, size-dependent properties (called "quantum size effects"). These materials will form the basis for many of the technological advances of the 21st Century. "The Nanoparticle Network" is a consortium dedicated to the exploration of different nanoscale materials and the origin of quantum size effects. The Network aims to enhance the uptake of all types of ....The Nanoparticle Network. Nanoscale materials are objects with one dimension less than about 20nm in size. Such exotic materials display unique, size-dependent properties (called "quantum size effects"). These materials will form the basis for many of the technological advances of the 21st Century. "The Nanoparticle Network" is a consortium dedicated to the exploration of different nanoscale materials and the origin of quantum size effects. The Network aims to enhance the uptake of all types of nanoparticle based technologies through an integrated network of scientists and engineers in conjunction with industry partners and government research institutions.
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Discovery Early Career Researcher Award - Grant ID: DE150100564
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Vascularized tumour models to elucidate the delivery of nanomedicine agents. This inter-disciplinary project aims to develop advances in in vitro models aimed at elucidating the delivery and transport of diagnostic and therapeutic nanomedicine agents in tumour tissues. The project aims to build on advanced tissue engineering principles and state-of-the-art micro-fabrication technologies to remove the limitation associated with animal studies and provide unprecedented mechanistic insights into th ....Vascularized tumour models to elucidate the delivery of nanomedicine agents. This inter-disciplinary project aims to develop advances in in vitro models aimed at elucidating the delivery and transport of diagnostic and therapeutic nanomedicine agents in tumour tissues. The project aims to build on advanced tissue engineering principles and state-of-the-art micro-fabrication technologies to remove the limitation associated with animal studies and provide unprecedented mechanistic insights into the delivery, transport and binding of nanomedicines into tumour tissues.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989915
Funder
Australian Research Council
Funding Amount
$127,000.00
Summary
X-ray Nano-scale Coherence Facility. Australia is rapidly developing into a world leader for x-ray imaging. This position has been supported by leading research groups and more recently by the development of the Australian Synchrotron. This project will fill a vital missing link in the experimental capability of Australian researchers - a flexible facility that can provide a nanoscale x-ray source. This enhanced capability will lead to new developments in coherent imaging methods. These new meth ....X-ray Nano-scale Coherence Facility. Australia is rapidly developing into a world leader for x-ray imaging. This position has been supported by leading research groups and more recently by the development of the Australian Synchrotron. This project will fill a vital missing link in the experimental capability of Australian researchers - a flexible facility that can provide a nanoscale x-ray source. This enhanced capability will lead to new developments in coherent imaging methods. These new methods will be used in the study of biological systems, leading to better drug design as well as in the study of materials, leading to stronger and lighter components. Read moreRead less
The Mechanics of Nanoscale Devices. Australian developments in biosensing, medical diagnostics, clean energy, communication and security technologies, are rapidly growing due to our mounting capacity in nanoscale fabrication. Vital for evolution of next-generation nanodevices is an understanding of how mechanical processes operate at such small scales. This application will contribute to this scientific knowledge base. This will in turn assist Australian industries to progress these applications ....The Mechanics of Nanoscale Devices. Australian developments in biosensing, medical diagnostics, clean energy, communication and security technologies, are rapidly growing due to our mounting capacity in nanoscale fabrication. Vital for evolution of next-generation nanodevices is an understanding of how mechanical processes operate at such small scales. This application will contribute to this scientific knowledge base. This will in turn assist Australian industries to progress these applications and devices, leading to economic, social and technological gains for the Australian community.Read moreRead less
Ultrafast photonic hammer: A new strategy to synthesise super-dense super-hard nanomaterials. We will develop a new way for laboratory synthesis of new classes of super-hard and super-dense materials at and above the extremely high temperature and density range currently accessible only in nuclear explosions. The ability of ultra-fast laser-induced phase transformations will be exploited aiming to form materials with exotic properties, which are theoretically predicted, but has not experimental ....Ultrafast photonic hammer: A new strategy to synthesise super-dense super-hard nanomaterials. We will develop a new way for laboratory synthesis of new classes of super-hard and super-dense materials at and above the extremely high temperature and density range currently accessible only in nuclear explosions. The ability of ultra-fast laser-induced phase transformations will be exploited aiming to form materials with exotic properties, which are theoretically predicted, but has not experimentally confirmed yet. Our new approach will have a profound interdisciplinary impact. The project will deliver underpinning knowledge, foremost practical expertise, and the prominent training of young researchers to secure Australia's international position among the leaders in the rapidly growing and competitive field of nanotechnology.Read moreRead less
Quantitative real-time imaging of high-temperature superconductors. This project will develop a robust technique for the quantitative real-time imaging of high-temperature superconductors. The image-analysis algorithm so obtained will be a virtual software lens, which is able to decode the information contained in data obtained by a well-established but hitherto qualitative imaging technique. We will transform this technique into one uniquely capable of obtaining two-dimensional movies of the ....Quantitative real-time imaging of high-temperature superconductors. This project will develop a robust technique for the quantitative real-time imaging of high-temperature superconductors. The image-analysis algorithm so obtained will be a virtual software lens, which is able to decode the information contained in data obtained by a well-established but hitherto qualitative imaging technique. We will transform this technique into one uniquely capable of obtaining two-dimensional movies of the current distributions, magnetic fields, and pinning defects in superconducting films. Such a quantitative characterization of these key superconductor parameters will be an important tool in the present global quest for room-temperature superconductivity.Read moreRead less