Discovery Early Career Researcher Award - Grant ID: DE150100564
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Vascularized tumour models to elucidate the delivery of nanomedicine agents. This inter-disciplinary project aims to develop advances in in vitro models aimed at elucidating the delivery and transport of diagnostic and therapeutic nanomedicine agents in tumour tissues. The project aims to build on advanced tissue engineering principles and state-of-the-art micro-fabrication technologies to remove the limitation associated with animal studies and provide unprecedented mechanistic insights into th ....Vascularized tumour models to elucidate the delivery of nanomedicine agents. This inter-disciplinary project aims to develop advances in in vitro models aimed at elucidating the delivery and transport of diagnostic and therapeutic nanomedicine agents in tumour tissues. The project aims to build on advanced tissue engineering principles and state-of-the-art micro-fabrication technologies to remove the limitation associated with animal studies and provide unprecedented mechanistic insights into the delivery, transport and binding of nanomedicines into tumour tissues.Read moreRead less
Special Research Initiatives - Grant ID: SR0354821
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Innovative Materials Production, Processing and Analysis Network. Materials science and engineering is decidedly interdisciplinary, covering a diverse spectrum of research from biology to construction, with an equally broad applications span encompassing all manufacturing industry. Australia has distinct strengths in materials but it has been difficult to promote sufficient interaction across discipline boundaries to fully exploit such strengths. The current network focuses on interdisciplinar ....Innovative Materials Production, Processing and Analysis Network. Materials science and engineering is decidedly interdisciplinary, covering a diverse spectrum of research from biology to construction, with an equally broad applications span encompassing all manufacturing industry. Australia has distinct strengths in materials but it has been difficult to promote sufficient interaction across discipline boundaries to fully exploit such strengths. The current network focuses on interdisciplinary materials interactions nationally by: i) bringing the materials community together at an annual workshop, ii) exposing PhD students and young researchers to cross-disciplinary research initiatives and facilities, iii) identifying common infrastructure needs, iv) linking with industry networks, eg AMTN, and to the international community.Read moreRead less
New materials and structures for next generation optical fibres. A soft glass optical fibre capability of critical importance to Australia's industrial and scientific capability will be established. This facility addresses a range of the National Research Priorities, most notably Defence, and brings fundamentally important technology to Australia. The proposed research capability strategically complements existing Australian silica-based fibre expertise and infrastructure. The aim is to develop ....New materials and structures for next generation optical fibres. A soft glass optical fibre capability of critical importance to Australia's industrial and scientific capability will be established. This facility addresses a range of the National Research Priorities, most notably Defence, and brings fundamentally important technology to Australia. The proposed research capability strategically complements existing Australian silica-based fibre expertise and infrastructure. The aim is to develop soft glass fibres for defence applications, and to develop fibre-based solutions for emerging applications in bionanophotonics. A key attraction of the platform technology proposed is its adaptability for testing concepts without requiring the support of large-scale fabrication and production industries.Read moreRead less
ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to unde ....ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to understand how single cells react to and communicate with their surroundings. This science will underpin a new generation of devices capable of probing the response of cells within individuals to environmental conditions or treatment, creating innovative and powerful new sensing platforms.Read moreRead less
Mathematical and mechanical models in nano-engineering and nanomedicine. The major environmental problems generated from global warming and the major human health problems, like cancer and diabetes, if they are to be solved at all, will most likely be resolved making use of advances in nanobiotechnology. This proposal will position Australia as a leader in the modelling of nanodevices such as gigahertz oscillators, nano-electromagnets, nanosensors, nanosyringes and nanoporous media suitable for ....Mathematical and mechanical models in nano-engineering and nanomedicine. The major environmental problems generated from global warming and the major human health problems, like cancer and diabetes, if they are to be solved at all, will most likely be resolved making use of advances in nanobiotechnology. This proposal will position Australia as a leader in the modelling of nanodevices such as gigahertz oscillators, nano-electromagnets, nanosensors, nanosyringes and nanoporous media suitable for hydrogen storage and gas separation, which will lead to new technologies and commercial spin-offs that will be of major benefit to this country. The applicants will develop a range of topics in nano-engineering and nanomedicine, training a team that will provide the next generation of researchers in these vital areas.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560657
Funder
Australian Research Council
Funding Amount
$740,000.00
Summary
Ultra-High Resolution NMR Imaging System for Nanotechnology including Nanobiotechnology. The ultra-high resolution imaging NMR spectrometer at the centre of this application is a generation ahead of comparable facilities in Australia and will extend the research capacity of numerous research groups comprising in excess of 50 academics and postgraduate students. The aims and significance of this infrastructure lie in it being one of the centrepieces of the partner institutions' aspirations to tak ....Ultra-High Resolution NMR Imaging System for Nanotechnology including Nanobiotechnology. The ultra-high resolution imaging NMR spectrometer at the centre of this application is a generation ahead of comparable facilities in Australia and will extend the research capacity of numerous research groups comprising in excess of 50 academics and postgraduate students. The aims and significance of this infrastructure lie in it being one of the centrepieces of the partner institutions' aspirations to take Australia to the cutting edge of nanotechnology and cognate disciplines many of which are areas of national priority. The expected manifold outcomes include research of the highest rank into fundamental problems of drug development through to applied outcomes such as new nanomaterials and improved horticulture/fruit preservation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100021
Funder
Australian Research Council
Funding Amount
$370,000.00
Summary
Orchestrating cellular processes by engineering silicon nanowire architectures. This project aims to improve gene transport by creating low-cost, easily implemented, programmable and controllable silicon nanowire-mediated transfection technology, and to demonstrate high-throughput, parallel trafficking of bioactive payloads. Success would enable the design and fabrication of nano–bio interfaces with closely controlled geometry and architecture, to orchestrate specific cellular processes such as ....Orchestrating cellular processes by engineering silicon nanowire architectures. This project aims to improve gene transport by creating low-cost, easily implemented, programmable and controllable silicon nanowire-mediated transfection technology, and to demonstrate high-throughput, parallel trafficking of bioactive payloads. Success would enable the design and fabrication of nano–bio interfaces with closely controlled geometry and architecture, to orchestrate specific cellular processes such as cellular reprogramming, adhesion, morphology, and differentiation with unprecedented efficiency and predictability. The advance could lead to breakthroughs in fundamental cellular studies, and better understanding of cell behaviour, function and fate.Read moreRead less
Properties of nanomaterials determine their disposal by liver cells. This project aims to understand how the liver handles and is affected by nanomaterials in the body. Nanomaterials are widely used in industrial, environmental, consumer and drug products, but how they affect human health is poorly understood. This project will characterise the spatiotemporal distribution of a set of nanomaterials with defined attributes in naïve and modified livers using chemistry, imaging and biological method ....Properties of nanomaterials determine their disposal by liver cells. This project aims to understand how the liver handles and is affected by nanomaterials in the body. Nanomaterials are widely used in industrial, environmental, consumer and drug products, but how they affect human health is poorly understood. This project will characterise the spatiotemporal distribution of a set of nanomaterials with defined attributes in naïve and modified livers using chemistry, imaging and biological methods. This work is expected to determine how nanomaterials’ attributes direct pathways for liver cell disposal and describe nanomaterial–liver interactions at the cellular level, information crucial in enabling safer nanomaterials for use in products such as drug formulations, sunscreens and cosmetics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100129
Funder
Australian Research Council
Funding Amount
$530,721.00
Summary
State-of-the-art atomic force microscopy facilities for South Australia. This project aims to transform our national capability in nano-(bio)characterisation by establishing a state-of-the-art atomic force microscopy (AFM) facility in South Australia. The facility will provide unparalleled capabilities not currently available in Australia and will catapult knowledge in multiple fields, from critical minerals and clean energy to mechanobiology. Expected outcomes include more efficient and eco-fri ....State-of-the-art atomic force microscopy facilities for South Australia. This project aims to transform our national capability in nano-(bio)characterisation by establishing a state-of-the-art atomic force microscopy (AFM) facility in South Australia. The facility will provide unparalleled capabilities not currently available in Australia and will catapult knowledge in multiple fields, from critical minerals and clean energy to mechanobiology. Expected outcomes include more efficient and eco-friendly resource recovery and energy production, future foods and cures, and advanced (bio)materials. The project will strengthen and amplify Australia’s capacity and global leadership to translate fundamental nano-scale phenomena and properties into innovative materials, technologies, and processes.Read moreRead less