Rejuvenating adult stem cells. This project aims to uncover intimate links between metabolic regulation and longevity in adult stem cells, the source of all cells in the body. Understanding why we age and whether ageing is preventable are research challenges which must be first attacked at a cellular level. This project will try to rejuvenate aged stem cells by interfering with a prospective molecular master switch of aging and also develop an approach to identify and select youthful stem cells. ....Rejuvenating adult stem cells. This project aims to uncover intimate links between metabolic regulation and longevity in adult stem cells, the source of all cells in the body. Understanding why we age and whether ageing is preventable are research challenges which must be first attacked at a cellular level. This project will try to rejuvenate aged stem cells by interfering with a prospective molecular master switch of aging and also develop an approach to identify and select youthful stem cells. The results are expected to be important beyond informing the science of ageing, in the areas of tissue engineering, wound healing, embryology and cancer.Read moreRead less
Unravelling the neutron lifetime puzzle with lattice quantum chromodynamics. This project will perform supercomputer simulations to confront one of the outstanding puzzles of nuclear and particle physics, the neutron lifetime. New knowledge will be generated through the development of novel theoretical and numerical techniques to increase the precision of the leading theoretical inputs required to predict the neutron lifetime. The outcomes will provide crucial theoretical guidance into understan ....Unravelling the neutron lifetime puzzle with lattice quantum chromodynamics. This project will perform supercomputer simulations to confront one of the outstanding puzzles of nuclear and particle physics, the neutron lifetime. New knowledge will be generated through the development of novel theoretical and numerical techniques to increase the precision of the leading theoretical inputs required to predict the neutron lifetime. The outcomes will provide crucial theoretical guidance into understanding the neutron; helping to guide the next-generation neutron experiments, from particle physics to applications in advanced materials science. The results will have immediate benefit by resolving the neutron lifetime puzzle, while enabling Australian scientists to take a leadership role in this area of fundamental science.Read moreRead less
Road rules for traffic on DNA - gene regulation by encounters between transcribing RNA polymerases and DNA-bound proteins. This project addresses a widespread but poorly understood phenomenon in gene regulation. The work will support Australian industries by supplying new tools for manipulation of gene expression for industrial and medical applications and will provide unique opportunities for Australian students in this emerging field.
Positron Nano-Dosimetry: Fundamental Measurements of Positron Interactions and their use in State-of-the-Art Modelling of Positron Transport. This proposal will provide unique experimental and theoretical information on how positrons, the electron antiparticles, interact with matter, in particular with biologically important molecules. This data will be used in a unique set of modelling approaches which will provide, for the first time, an insight into how positrons are transported through gases ....Positron Nano-Dosimetry: Fundamental Measurements of Positron Interactions and their use in State-of-the-Art Modelling of Positron Transport. This proposal will provide unique experimental and theoretical information on how positrons, the electron antiparticles, interact with matter, in particular with biologically important molecules. This data will be used in a unique set of modelling approaches which will provide, for the first time, an insight into how positrons are transported through gases, liquids and ultimately, soft matter. It will thus have important ramifications for diagnostic tools such as Positron Emission Tomography. The fundamental research will also shed light on one of the key 'mysteries' of life - why the biological building blocks of life possess a definite " handedness", or chirality.Read moreRead less
Excitation spectra of quantum chromodynamics. Just as quantum electrodynamics describes the quantum mechanical excitation spectra of atomic systems, quantum chromodynamics (QCD) describes the excitation spectra of quark and gluon systems, such as the proton. This project will resolve the interactions underpinning the excitations of QCD, as being investigated at international facilities.
Elucidating the role of quantum electrodynamics in hadron properties. This project will explore the fundamental mechanisms of nature making the neutron heavier than the proton; governing which nuclei are stable; and determining the current state of the Universe. Drawing on substantial supercomputing resources made available through international collaboration, this project will perform the first ab-initio simulation combining the quantum field theories governing elementary quarks, gluons, electr ....Elucidating the role of quantum electrodynamics in hadron properties. This project will explore the fundamental mechanisms of nature making the neutron heavier than the proton; governing which nuclei are stable; and determining the current state of the Universe. Drawing on substantial supercomputing resources made available through international collaboration, this project will perform the first ab-initio simulation combining the quantum field theories governing elementary quarks, gluons, electrons and photons; namely quantum chromodynamics and quantum electrodynamics. This project will develop novel theoretical and numerical techniques to confront the otherwise elusive electromagnetic contributions to hadronic properties and in doing so, address a wide range of important aspects of hadron structure and interactions.Read moreRead less
Structure of Hadronic Excitations from Lattice Quantum Chromodynamics. Quantum chromodynamics describes the fundamental strong interactions between quarks and gluons as they compose hadrons such as the proton or neutron. Beyond these lowest-energy systems, the quantum mechanical excitation spectra display a rich and complex structure. Remarkably, little is known about the internal structure of these states. The central goal of this project is to unveil the nature of hadrons and their excited sta ....Structure of Hadronic Excitations from Lattice Quantum Chromodynamics. Quantum chromodynamics describes the fundamental strong interactions between quarks and gluons as they compose hadrons such as the proton or neutron. Beyond these lowest-energy systems, the quantum mechanical excitation spectra display a rich and complex structure. Remarkably, little is known about the internal structure of these states. The central goal of this project is to unveil the nature of hadrons and their excited states using the first principles approach of lattice gauge theory. By elucidating aspects of hadron structure in terms of the most fundamental non-perturbative quark and gluon fields, the project will create new knowledge impacting on renowned experimental programs at international facilities.Read moreRead less
Electromagnetic structure of hadronic excitations from lattice quantum chromodynamics. Just as quantum electrodynamics describes the quantum mechanical excitation spectra of atomic systems, quantum chromodynamics (QCD) describes the excitation spectra of quark and gluon systems, such as the proton. This project will resolve the internal structure of the low-lying excitations of QCD, as being investigated at international facilities.
Sub-wavelength light confinement. This project will introduce and demonstrate new concepts for confining and patterning light on sub-wavelength scales. Building on Australian expertise in optical fibre technologies, this fundamental research will enhance Australia's position at the forefront of international research in the nanoscale control of light. These concepts also promise to lead to patentable new tools for ultra high-resolution imaging and for manipulating materials. This project will en ....Sub-wavelength light confinement. This project will introduce and demonstrate new concepts for confining and patterning light on sub-wavelength scales. Building on Australian expertise in optical fibre technologies, this fundamental research will enhance Australia's position at the forefront of international research in the nanoscale control of light. These concepts also promise to lead to patentable new tools for ultra high-resolution imaging and for manipulating materials. This project will enhance Australia's international links, build on a range of national research programs, and provide training of researchers in photonics, which will be of benefit to Australian industry and research.Read moreRead less
Foundations of the nuclear force, nuclear structure and dynamics. This project aims to investigate a profound problem in physics: the structure and interactions of atomic nuclei in terms of their microscopic constituents. It is expected to generate new knowledge and improve our understanding of the structure and dynamics of nuclei, their formation in the cosmos, neutron star properties, and underpin future nuclear technologies. The project aims to leverage Australian capacity in nuclear theory t ....Foundations of the nuclear force, nuclear structure and dynamics. This project aims to investigate a profound problem in physics: the structure and interactions of atomic nuclei in terms of their microscopic constituents. It is expected to generate new knowledge and improve our understanding of the structure and dynamics of nuclei, their formation in the cosmos, neutron star properties, and underpin future nuclear technologies. The project aims to leverage Australian capacity in nuclear theory to produce the first predictive model with a modern realistic nuclear interaction. Significant benefits include an enhancement of research training capacity and new international links with the world's major laboratories. Read moreRead less