The role of internal wave-driven near-bed turbulent dynamics in coastal ocean sediment mobilisation. This project will determine the process of internal wave-driven sediment resuspension and transport in the coastal ocean. This will be achieved by using a combination of field observations and numerical modelling, at two diverse but representative Australian coastal regions where nonlinear internal waves dominate the dynamics. The study has significant application to the offshore oil and gas indu ....The role of internal wave-driven near-bed turbulent dynamics in coastal ocean sediment mobilisation. This project will determine the process of internal wave-driven sediment resuspension and transport in the coastal ocean. This will be achieved by using a combination of field observations and numerical modelling, at two diverse but representative Australian coastal regions where nonlinear internal waves dominate the dynamics. The study has significant application to the offshore oil and gas industry engineering design and operations as well as to environmental management of the coastal ocean ecosystems. This project will achieve a process understanding and create predictive tools describing sediment resuspension and transport for use by industry and marine managers.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100114
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
Multi-scale imaging and characterisation facility for biological structure and function. Discovery in biology will lead to significant social and economic impact improving Australians' lives. This facility will allow researchers to study the micro and nanoscales structure and function of cells, tissues and organs. The knowledge gained will have direct benefits and applications to human and animal health, drug and food technology.
5D Imaging Flow Cytometry for in vivo Quantification of Biological Fluids. Rapid and accurate quantification of live biological fluid properties at sub-cellular and molecular levels forms the bedrock of biofluidic sciences. Majority of the biofluidic devices rely on quantifying biological fluids after its removal from the body in an in vitro Flow Cytometer (FC). FC faces many caveats i.e. biological degradation and small volume etc. In this project, we shall engineer the first in vivo 5D imaging ....5D Imaging Flow Cytometry for in vivo Quantification of Biological Fluids. Rapid and accurate quantification of live biological fluid properties at sub-cellular and molecular levels forms the bedrock of biofluidic sciences. Majority of the biofluidic devices rely on quantifying biological fluids after its removal from the body in an in vitro Flow Cytometer (FC). FC faces many caveats i.e. biological degradation and small volume etc. In this project, we shall engineer the first in vivo 5D imaging flow cytometer (5D IFC) capable of continuous assessment of potentially entire blood volume in a living mice without removing fluid out of the body. The project represents a major advancement beyond any existing flow cytometer and overcome the engineering limits of state-of-art laser scanning imaging devices.Read moreRead less
The colour of cellular aging: a deep probe of cellular processes. Understanding why we age and whether aging is preventable are profound research challenges, which must be first tackled at a cellular level. Building on our advances in non-invasive colour monitoring of cell function, this project aims to uncover intimate links between cellular processes and aging in cells that must survive for many decades such as oocytes and neurons. We will explore the tantalising possibility to rejuvenate such ....The colour of cellular aging: a deep probe of cellular processes. Understanding why we age and whether aging is preventable are profound research challenges, which must be first tackled at a cellular level. Building on our advances in non-invasive colour monitoring of cell function, this project aims to uncover intimate links between cellular processes and aging in cells that must survive for many decades such as oocytes and neurons. We will explore the tantalising possibility to rejuvenate such aged cells by interfering with molecular master switches of aging. A unique machine learning approach will be applied for finding the most effective interventions. The results will have broad impact beyond the science of aging, in the areas of female fertility, neurodegeneration and immunity.
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Discovery Early Career Researcher Award - Grant ID: DE130101191
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Formation of the osteocyte network in bone matrix. The formation of new bone, which occurs throughout life for bone renewal and acutely after fractures, entraps a network of cells that can detect micro-damage and direct repair mechanisms. Mathematical and computational methods will be used to understand how this network can lead to a self-detecting and self-repairing biomaterial.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100185
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
High throughput microbial microculture and single cell analysis facility. High throughput microbial microculture and single cell analysis facility:
To support the emerging research area of microbial heterogeneity and variation in response to conditions, this project aims to establish a facility centred on a 24-microbioreactor system for high throughput microbial culturing. This is designed to be connected to two complementary analysis techniques – flow cytometry and high resolution infra-red mi ....High throughput microbial microculture and single cell analysis facility. High throughput microbial microculture and single cell analysis facility:
To support the emerging research area of microbial heterogeneity and variation in response to conditions, this project aims to establish a facility centred on a 24-microbioreactor system for high throughput microbial culturing. This is designed to be connected to two complementary analysis techniques – flow cytometry and high resolution infra-red microscopy – for the non-destructive measurement of metabolic activities and mapping of constituents of whole cells. This would help us to determine the variation in response between organisms, to guide cell line development and process optimisation for a wide range of biotechnology applications. Expected outcomes may apply to Australia’s brewing, wine, food processing, aquaculture, biofuels, biomedical and biotechnology industries.Read moreRead less
Rejuvenating adult stem cells. This project aims to uncover intimate links between metabolic regulation and longevity in adult stem cells, the source of all cells in the body. Understanding why we age and whether ageing is preventable are research challenges which must be first attacked at a cellular level. This project will try to rejuvenate aged stem cells by interfering with a prospective molecular master switch of aging and also develop an approach to identify and select youthful stem cells. ....Rejuvenating adult stem cells. This project aims to uncover intimate links between metabolic regulation and longevity in adult stem cells, the source of all cells in the body. Understanding why we age and whether ageing is preventable are research challenges which must be first attacked at a cellular level. This project will try to rejuvenate aged stem cells by interfering with a prospective molecular master switch of aging and also develop an approach to identify and select youthful stem cells. The results are expected to be important beyond informing the science of ageing, in the areas of tissue engineering, wound healing, embryology and cancer.Read moreRead less
How do mechanics, neural drive and muscle architecture interact in muscles? This project will determine how an individual person’s muscle activity, muscle structure and mechanical properties, and the local mechanical conditions around the muscle interact as muscles move and deform, by using experiments and personalised computational models that can examine these factors and their interactions concurrently. To achieve this, we will develop novel magnetic resonance imaging methods to measure the m ....How do mechanics, neural drive and muscle architecture interact in muscles? This project will determine how an individual person’s muscle activity, muscle structure and mechanical properties, and the local mechanical conditions around the muscle interact as muscles move and deform, by using experiments and personalised computational models that can examine these factors and their interactions concurrently. To achieve this, we will develop novel magnetic resonance imaging methods to measure the mechanical properties of muscles in humans and methods for modelling muscles. As well as answering fundamental scientific questions about muscle function, these new techniques will provide a platform for studying other muscles, and for future development of muscle training methods and technologies to optimise muscle function.Read moreRead less
Microfluidic platforms for studying foam cell formation in vessels . This project aims to create technology platforms, utilising microfluidics and machine learning, to study the fundamental biological processes underlying the accumulation of immune cells underneath the vessel wall, which is known as foam cell formation. This project expects to deliver technologies, which facilitate mimicking and analysis of the complex dynamics of the human vessels in a more accurate, time- and cost-effective ma ....Microfluidic platforms for studying foam cell formation in vessels . This project aims to create technology platforms, utilising microfluidics and machine learning, to study the fundamental biological processes underlying the accumulation of immune cells underneath the vessel wall, which is known as foam cell formation. This project expects to deliver technologies, which facilitate mimicking and analysis of the complex dynamics of the human vessels in a more accurate, time- and cost-effective manner. The expected outcome will be cutting-edge tools and techniques to better understand the fundamental biological mechanisms driving foam cell formation. This should facilitate the development of future cardiovascular drug discovery technologies, which would benefit the biotechnology and pharmaceutical industries.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100757
Funder
Australian Research Council
Funding Amount
$447,654.00
Summary
Engineering Tissue Organisation Using Intelligent Additive Biomanufacturing. This project aims to organize and shape the formation of lab-grown tissue by 3D printing structures which control the behaviour of cells. This cell behaviour control will be accomplished through an interdisciplinary and multiscale pipeline of additive micromanufacturing, bioreactor engineering, cell culture, single-cell imaging, and computational modelling. In contrast with current empirical approaches, this quantitativ ....Engineering Tissue Organisation Using Intelligent Additive Biomanufacturing. This project aims to organize and shape the formation of lab-grown tissue by 3D printing structures which control the behaviour of cells. This cell behaviour control will be accomplished through an interdisciplinary and multiscale pipeline of additive micromanufacturing, bioreactor engineering, cell culture, single-cell imaging, and computational modelling. In contrast with current empirical approaches, this quantitative and predictive understanding of how to control biological processes within 3D printed environments will design and engineer more robust, customisable, scalable, and economical cell culture platforms able to optimally manufacture bespoke and complex 3D tissues for future agricultural, pharmaceutical, or medical products.Read moreRead less