A longitudinal study of neuropsychological and neuromotor effects of low level manganese exposure. This study will investigate the neuropsychological and neuromotor effects of low level exposure to mangenese particulate. Previous studies have indicated symptomology of high level exposure, but there is contention in the literature regarding the effects of low levels of exposure. Our aim is to refine measures of cumulative exposure and develop a more comprehensive and senstitive testing protocol t ....A longitudinal study of neuropsychological and neuromotor effects of low level manganese exposure. This study will investigate the neuropsychological and neuromotor effects of low level exposure to mangenese particulate. Previous studies have indicated symptomology of high level exposure, but there is contention in the literature regarding the effects of low levels of exposure. Our aim is to refine measures of cumulative exposure and develop a more comprehensive and senstitive testing protocol than has been reported thus far. These measures and protocols will be incorporated into a longitudinal design, which has not been conducted in research studies to date. In addition, a database of exposure variables will be developed to facilitate long-term, accurate research into the effects of the low levels of exposure.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100350
Funder
Australian Research Council
Funding Amount
$375,042.00
Summary
Decoding unstable decision preferences from brain activity. We often have to make decisions despite lacking clear preferences. This leaves us susceptible to biases from stimuli and information in our environment. This project investigates how simple, perceptual decisions and financial decisions are influenced by contextual information. The project will combine state-of-the-art neuroimaging technology with machine learning methods to develop a novel decision-decoding toolbox that directly predict ....Decoding unstable decision preferences from brain activity. We often have to make decisions despite lacking clear preferences. This leaves us susceptible to biases from stimuli and information in our environment. This project investigates how simple, perceptual decisions and financial decisions are influenced by contextual information. The project will combine state-of-the-art neuroimaging technology with machine learning methods to develop a novel decision-decoding toolbox that directly predicts decision outcomes from brain activity. This will allow investigation of how decision encoding in the brain changes under the influence of contextual information, and will provide the basis for developing an advanced model for human decision-making in real-life situations.Read moreRead less
Single and dual process models of recognition memory: Reconciliation of behavioural, electrophysiological, and neuroimaging data. Advanced brain scanning technologies are increasingly used to study human memory. As well as being important for our basic understanding of memory, they also tell us how memory is affected by normal development, ageing, disease, and injury. Unfortunately, because these technologies are so new, a gap has opened up between our psychological understanding of memory and t ....Single and dual process models of recognition memory: Reconciliation of behavioural, electrophysiological, and neuroimaging data. Advanced brain scanning technologies are increasingly used to study human memory. As well as being important for our basic understanding of memory, they also tell us how memory is affected by normal development, ageing, disease, and injury. Unfortunately, because these technologies are so new, a gap has opened up between our psychological understanding of memory and the physiological events measured by the scanning technologies. This has created a problem for how we should interpret the results that are found. The present project aims to close this gap by applying new research methodologies and theoretical insights based on our previous research.Read moreRead less
How we recognise the orientation of objects: a combined neurophyschological / eye movement study. Neurophyschological evidence suggests that different visual attributes of objects (e.g. shape vs orientation in space) are processed by independent brain systems. This project aims to investigate this issue systematically, using both neurological patients and normal volunteers. By using sensitive experimental measures, including detailed analyses of subject's eye movements while they view objects, ....How we recognise the orientation of objects: a combined neurophyschological / eye movement study. Neurophyschological evidence suggests that different visual attributes of objects (e.g. shape vs orientation in space) are processed by independent brain systems. This project aims to investigate this issue systematically, using both neurological patients and normal volunteers. By using sensitive experimental measures, including detailed analyses of subject's eye movements while they view objects, this research will provide valuable insights into how the visual system gathers and encodes information about different object attributes.Read moreRead less
Evidence-based improvement of statistical inference practices in psychology and other disciplines. The commonest ways that many researchers currently draw conclusions from their data have been shown to be inefficient, and often used incorrectly. This project will develop new, better statistical representations and software tools for data analysis. It will evaluate and demonstrate the effectiveness of these. Wide adoption of these techniques and tools will enhance the international reputation ....Evidence-based improvement of statistical inference practices in psychology and other disciplines. The commonest ways that many researchers currently draw conclusions from their data have been shown to be inefficient, and often used incorrectly. This project will develop new, better statistical representations and software tools for data analysis. It will evaluate and demonstrate the effectiveness of these. Wide adoption of these techniques and tools will enhance the international reputation and competitiveness of Australian psychological science. Adoption by Australian researchers across the social and behavioural sciences, and in other disciplines including medicine, economics and ecology, will improve the efficiency and effectiveness of Australian research, with consequential wide-ranging benefits to the Australian community.Read moreRead less
Do director board appointments predict whether CEO pay is in line with company performance? Increasing pay differences between CEOs and the average working Australian have resulted in a less equitable and economically divided society. This issue has reached a critical point as taxpayer money is now needed to fund stimulus packages and finance companies facing insolvency while CEO pay on average has remained unchanged or increased. This inequity has the potential to cause social and political ins ....Do director board appointments predict whether CEO pay is in line with company performance? Increasing pay differences between CEOs and the average working Australian have resulted in a less equitable and economically divided society. This issue has reached a critical point as taxpayer money is now needed to fund stimulus packages and finance companies facing insolvency while CEO pay on average has remained unchanged or increased. This inequity has the potential to cause social and political instability. This research will provide much needed knowledge of how to address this issue including pay benchmarks, knowledge derived from international practice, corporate governance indices as well as understanding of how widespread pay norms have developed.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100741
Funder
Australian Research Council
Funding Amount
$342,996.00
Summary
Harnessing neural plasticity with brain stimulation. This project aims to investigate the links between the molecular mechanisms underlying brain plasticity and the effects of non-invasive brain stimulation. It will use a novel approach that integrates genetics, electrophysiology and biological modelling. Plasticity underpins all learning, memory and aging. Brain stimulation can drive plasticity in humans, but these effects are extremely difficult to harness and vary widely between people. Expec ....Harnessing neural plasticity with brain stimulation. This project aims to investigate the links between the molecular mechanisms underlying brain plasticity and the effects of non-invasive brain stimulation. It will use a novel approach that integrates genetics, electrophysiology and biological modelling. Plasticity underpins all learning, memory and aging. Brain stimulation can drive plasticity in humans, but these effects are extremely difficult to harness and vary widely between people. Expected outcomes include a critical understanding of the fundamental mechanisms governing plasticity. This will provide significant benefits such as the development of individually optimised brain stimulation protocols, enabling tailored, reliable approaches to address brain function and cognition.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100694
Funder
Australian Research Council
Funding Amount
$372,014.00
Summary
Does disconnection in the aging brain cause age-related movement decline? This project aims to use new neurophysiological approaches to understand the causal role of age-related changes in brain network connectivity to the movement control. Brain regions interact through complex and dynamic neural networks to control voluntary movement, but whether age-related changes in network connectivity drive age-related decline in movement control is unknown. This project will provide significant benefits ....Does disconnection in the aging brain cause age-related movement decline? This project aims to use new neurophysiological approaches to understand the causal role of age-related changes in brain network connectivity to the movement control. Brain regions interact through complex and dynamic neural networks to control voluntary movement, but whether age-related changes in network connectivity drive age-related decline in movement control is unknown. This project will provide significant benefits such as the neurophysiological knowledge required to develop targeted interventions to improve movement control in the aging population.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100575
Funder
Australian Research Council
Funding Amount
$423,604.00
Summary
Does neuroplasticity protect against late life cognitive impairment? This project aims to investigate neuroplasticity across the adult lifespan, using novel neurophysiological approaches to determine its role in protecting against age-related cognitive decline. This project expects to generate new knowledge in the area of human cognitive ageing, using an innovative and interdisciplinary approach. Expected outcomes of this project include a critical understanding of the basic neural mechanisms of ....Does neuroplasticity protect against late life cognitive impairment? This project aims to investigate neuroplasticity across the adult lifespan, using novel neurophysiological approaches to determine its role in protecting against age-related cognitive decline. This project expects to generate new knowledge in the area of human cognitive ageing, using an innovative and interdisciplinary approach. Expected outcomes of this project include a critical understanding of the basic neural mechanisms of healthy brain ageing. This will provide significant benefits, such as the neurophysiological knowledge required to develop novel biological markers to detect, as well as therapeutic agents to curb, cognitive decline in the aging population.Read moreRead less
Understanding working memory: from cells to brain stimulation. This project aims to understand the neural mechanisms of working memory, a fundamental cognitive function in humans, using a novel framework which combines non-invasive brain stimulation, neuroimaging, pharmacological and experimental manipulations, and biological modelling. Expected outcomes include a critical understanding of the cellular mechanisms underlying both neural activity and working memory ability in healthy individuals a ....Understanding working memory: from cells to brain stimulation. This project aims to understand the neural mechanisms of working memory, a fundamental cognitive function in humans, using a novel framework which combines non-invasive brain stimulation, neuroimaging, pharmacological and experimental manipulations, and biological modelling. Expected outcomes include a critical understanding of the cellular mechanisms underlying both neural activity and working memory ability in healthy individuals and a detailed knowledge of how to non-invasively interact with these mechanisms using brain stimulation. This will provide significant benefits such as the development of individually optimised brain stimulation protocols, enabling tailored approaches to reliably alter brain function and cognition.Read moreRead less