Androgen receptor: A master regulator of lipid metabolism. This project aims to understand how male sex hormones, or androgens, affect the amount and metabolism of fats in normal body tissues. By integrating our multi-disciplinary expertise in androgen action, molecular biology, metabolism and bioinformatics with novel techniques and instrumentation, this collaboration expects to generate the first detailed picture of how fat metabolism is controlled by androgens in humans, and how closely this ....Androgen receptor: A master regulator of lipid metabolism. This project aims to understand how male sex hormones, or androgens, affect the amount and metabolism of fats in normal body tissues. By integrating our multi-disciplinary expertise in androgen action, molecular biology, metabolism and bioinformatics with novel techniques and instrumentation, this collaboration expects to generate the first detailed picture of how fat metabolism is controlled by androgens in humans, and how closely this relates to mice. Expected outcomes and benefits will be a new understanding of which aspects of fat metabolism are most influenced by androgens, and an ability to anticipate potential metabolic impacts of natural or pharmacological fluctuations in androgen levels in humans, laboratory animals and livestock.Read moreRead less
A network perspective for ecosystem responses to plant invasion. Invasive species are key drivers of global change, yet, our understanding of their negative impacts on ecosystems is limited within many contexts. This project will provide the first large-scale test for interactions between plants and microbes, via network analyses, as yardsticks for invasive species impacts on ecosystems. Using innovative approaches that link interactions network properties with ecosystem functioning, the fundame ....A network perspective for ecosystem responses to plant invasion. Invasive species are key drivers of global change, yet, our understanding of their negative impacts on ecosystems is limited within many contexts. This project will provide the first large-scale test for interactions between plants and microbes, via network analyses, as yardsticks for invasive species impacts on ecosystems. Using innovative approaches that link interactions network properties with ecosystem functioning, the fundamental data generated in this study will answer unsolved theoretical questions, providing evidence for the use of networks to predict and mitigate invader impacts. These benefits are not only crucial for biodiversity managers but also for those responsible for sustainable crop development under future climates.Read moreRead less
Assembling the building blocks in the blueprint of the embryonic head. This project aims to profile and impute the genome activity and validate the cellular and molecular mechanism underpinning the generation, in time and space, of diverse types of tissues that constitute the building blocks of the embryonic head. The knowledge gain enriches our understanding of the early steps of head formation during embryogenesis in the context of the niche conditions associated with the acquisition of progen ....Assembling the building blocks in the blueprint of the embryonic head. This project aims to profile and impute the genome activity and validate the cellular and molecular mechanism underpinning the generation, in time and space, of diverse types of tissues that constitute the building blocks of the embryonic head. The knowledge gain enriches our understanding of the early steps of head formation during embryogenesis in the context of the niche conditions associated with the acquisition of progenitor state, enhancement of lineage propensity, and driving early lineage differentiation. Expected outcome of this research on the developmental biology of a model organism provides a framework of the mechanism of establishing a blueprint of development that may be conserved across multiple mammalian species.Read moreRead less
Securing Web-based Services by Policy Coherence and Proof-checking. This project aims to develop a provably correct cybersecurity system for workflows, which enables organizations to provide flexible and more secure web-based services and business communication. The project expects to generate new knowledge, theoretic advancement and result in new technologies in the areas of internet of things and cybersecurity. The expected outcomes include a software tool with documentation, which helps organ ....Securing Web-based Services by Policy Coherence and Proof-checking. This project aims to develop a provably correct cybersecurity system for workflows, which enables organizations to provide flexible and more secure web-based services and business communication. The project expects to generate new knowledge, theoretic advancement and result in new technologies in the areas of internet of things and cybersecurity. The expected outcomes include a software tool with documentation, which helps organisations achieve operational excellence and security, and maintain a trusted environment for end users. This system will provide significant economic and commercial benefits to business and end users with highly secured web-services and improved productivity through a coherent framework and proof-checked workflows.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100116
Funder
Australian Research Council
Funding Amount
$419,218.00
Summary
Vulnerability Defence: From Interpretable to Trustworthy Threat Assessment. This project aims to design a novel vulnerability defence framework to automatically identify, prioritise and interpret vulnerabilities and their attack vectors from the Internet of Things (IoT). Currently, most Australian organisations can be targeted by complex cyberattacks, stealing sensitive information leading to financial loss and reputation threats. This project expects to generate new knowledge in IoT vulnerabili ....Vulnerability Defence: From Interpretable to Trustworthy Threat Assessment. This project aims to design a novel vulnerability defence framework to automatically identify, prioritise and interpret vulnerabilities and their attack vectors from the Internet of Things (IoT). Currently, most Australian organisations can be targeted by complex cyberattacks, stealing sensitive information leading to financial loss and reputation threats. This project expects to generate new knowledge in IoT vulnerability assessment using economic risk estimation and cognitive vulnerability identification methods. Expected outcomes include trusted IoT vulnerability assessment methods and vulnerability testbed. Significant benefits are expected to protect IoT networks in all defence, industry and government sectors.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101344
Funder
Australian Research Council
Funding Amount
$364,981.00
Summary
Advancing genomic-driven infectious diseases modelling. Emerging infectious diseases and antimicrobial resistance are among the greatest threats to Australian health and agriculture, and current surveillance tools may fail to detect and mitigate infectious disease outbreaks in real time. This project will develop advanced phylodynamic methods (i.e., mathematical models of infectious disease transmission and pathogen evolution) to enable real-time surveillance of infectious disease outbreaks as t ....Advancing genomic-driven infectious diseases modelling. Emerging infectious diseases and antimicrobial resistance are among the greatest threats to Australian health and agriculture, and current surveillance tools may fail to detect and mitigate infectious disease outbreaks in real time. This project will develop advanced phylodynamic methods (i.e., mathematical models of infectious disease transmission and pathogen evolution) to enable real-time surveillance of infectious disease outbreaks as they emerge and monitor levels of drug resistance.Read moreRead less
High Quality-of-Experience Real-time Video for Smart Online Shopping. This project aims to develop high quality-of-experience real-time video systems for smart shopping applications by devising new deep-neural-network-enhanced video delivery schemes. It will generate new knowledge of combined AI and network solutions to achieve high-quality and low-latency real-time video delivery, addressing unsatisfactory user experience intrinsically caused by network delay and bandwidth. Fundamental principl ....High Quality-of-Experience Real-time Video for Smart Online Shopping. This project aims to develop high quality-of-experience real-time video systems for smart shopping applications by devising new deep-neural-network-enhanced video delivery schemes. It will generate new knowledge of combined AI and network solutions to achieve high-quality and low-latency real-time video delivery, addressing unsatisfactory user experience intrinsically caused by network delay and bandwidth. Fundamental principles and an all-in-one platform will be developed to address research problems and the industrial partner’s practical problems. It will significantly benefit all shopping businesses and their customers in Australia, as well as all other video-related services (e.g., online education, video conferencing, etc.).Read moreRead less
Efficient phylogenetic methods that manage the curse of genomic complexity. This project aims to develop new methods and software to infer the evolutionary history of organisms using genomic data. These new phylogenomic methods need to take account of the complexity of evolutionary processes and/or patterns in time (along the evolutionary tree) and space (along the genome). This project is significant because these methods must merge mathematics and statistics with High-Performance Computing to ....Efficient phylogenetic methods that manage the curse of genomic complexity. This project aims to develop new methods and software to infer the evolutionary history of organisms using genomic data. These new phylogenomic methods need to take account of the complexity of evolutionary processes and/or patterns in time (along the evolutionary tree) and space (along the genome). This project is significant because these methods must merge mathematics and statistics with High-Performance Computing to handle the huge quantities of genetic data and the complexity of evolution itself. An important expected outcome of this project will be the development and release of freely-available software that incorporates these new methods. This project expects to benefit scientists who need to infer phylogenies from genomic data. Read moreRead less
Testing links between genomic and morphological evolutionary rates. This project aims to identify, understand, and characterise patterns of evolutionary rates across different levels of biological variation. The project expects to generate knowledge about the tempo and mode of evolution by using a phylogenetic approach to test fundamental models of evolutionary rates, including the link between rates of genomic and morphological evolution. Expected outcomes of this project include detailed insig ....Testing links between genomic and morphological evolutionary rates. This project aims to identify, understand, and characterise patterns of evolutionary rates across different levels of biological variation. The project expects to generate knowledge about the tempo and mode of evolution by using a phylogenetic approach to test fundamental models of evolutionary rates, including the link between rates of genomic and morphological evolution. Expected outcomes of this project include detailed insights into the tempo and mode of macroevolution, better modelling of genomic and phenotypic evolution, and improved design of studies in evolutionary genomics. Benefits of the project include greater understanding of the evolutionary processes that have generated the diversity of the Australian biota.Read moreRead less
Dynamic evolution of mutation rates: causes and impacts on genomic analysis. This project aims to illuminate the role of variation in mutation rate in driving evolutionary change. Mutation rate is a core parameter in evolutionary analyses in essential applications including epidemiology, conservation and medicine, yet remains a “black box” given arbitrary universal values. This project will take a whole-of-biodiversity approach to understanding the forces shaping mutation rate, impact on evoluti ....Dynamic evolution of mutation rates: causes and impacts on genomic analysis. This project aims to illuminate the role of variation in mutation rate in driving evolutionary change. Mutation rate is a core parameter in evolutionary analyses in essential applications including epidemiology, conservation and medicine, yet remains a “black box” given arbitrary universal values. This project will take a whole-of-biodiversity approach to understanding the forces shaping mutation rate, impact on evolution of biodiversity and effect on accuracy and precision of phylogenetic analyses. Using Australian case studies, the expected outcome of this project will be a greater understanding variation in mutation rate between species, providing significant benefits in developing more sophisticated and reliable phylogenetic analyses.Read moreRead less