New mathematics of fractional diffusion for understanding cognitive impairment at the neuronal level. As Australia's population ages, cognitive impairment due to cortical ageing and neurodegeneration is looming as the nation's greatest health problem. The project will deliver new, more realistic, mathematical models for a mechanistic understanding of cognitive impairment at the neuronal level. This understanding is a vital first step in targeting drugs, e.g., to influence neuronal spine proper ....New mathematics of fractional diffusion for understanding cognitive impairment at the neuronal level. As Australia's population ages, cognitive impairment due to cortical ageing and neurodegeneration is looming as the nation's greatest health problem. The project will deliver new, more realistic, mathematical models for a mechanistic understanding of cognitive impairment at the neuronal level. This understanding is a vital first step in targeting drugs, e.g., to influence neuronal spine properties, for preventative health care. The project will maintain international collaborations, between applied mathematicians at UNSW, Sydney and biomathematicians and neuroscientists at Mount Sinai School of Medicine, New York, providing ongoing training opportunities for Australian scientists in this cutting edge biomathematical research.Read moreRead less
Emerging applications of advanced computational methods and discrete mathematics. Ongoing improvements in computer performance are revolutionising research in combinatorial discrete mathematics, and leading to exciting new applications in information technology and the biological and chemical sciences. As a result, substantial international research effort, both at universities and in commercial and industrial organisations, is being channelled into high-performance computation and theoretical p ....Emerging applications of advanced computational methods and discrete mathematics. Ongoing improvements in computer performance are revolutionising research in combinatorial discrete mathematics, and leading to exciting new applications in information technology and the biological and chemical sciences. As a result, substantial international research effort, both at universities and in commercial and industrial organisations, is being channelled into high-performance computation and theoretical problems in combinatorial mathematics. Our aim is to develop and apply advanced computational methods through the study of several unsolved theoretical problems in design theory and practical problems in exact matrix computation and drug design.Read moreRead less
Algebraic evolution and evolutionary algebra. Algebra and biology have developed in extraordinary ways over the last half century yet, to date, the use of algebraic ideas in biology has been limited. This project will address this by modelling evolutionary processes in bacteria using algebraic ideas.
Algebraic algorithms for investigating the space of bacterial genomes. Understanding evolutionary processes and the way organisms are related is a fundamental objective of the biological sciences. This project brings the power of group theory and computation to bear on these problems, developing new ways of understanding them and new tools to address them.
The fundamental structure of combinatorial configurations. Combinatorial configurations are fundamental mathematical tools used to model physical problems in the information sciences. Combinatorial trades arise from the differences between combinatorial configurations. They uniquely determine the underlying structure of the configuration and are central to the determination of defining sets. With this proposal we shall study the existence, properties and applications of combinatorial trades and ....The fundamental structure of combinatorial configurations. Combinatorial configurations are fundamental mathematical tools used to model physical problems in the information sciences. Combinatorial trades arise from the differences between combinatorial configurations. They uniquely determine the underlying structure of the configuration and are central to the determination of defining sets. With this proposal we shall study the existence, properties and applications of combinatorial trades and the associated defining sets. Our results will have applications in the areas of biotechnology, information systems, information security and experimental design.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100957
Funder
Australian Research Council
Funding Amount
$339,328.00
Summary
Partial differential equations, free boundaries and applications. This project aims to investigate fundamental problems in the analysis of partial differential equations and free boundary theory, to develop advanced mathematical theories with the possibility of important applications. The expected outcome is the establishment of a regularity and classification theory for nonlocal equations and for free boundary problems in linear and nonlinear settings. The benefit of the project lies in a concr ....Partial differential equations, free boundaries and applications. This project aims to investigate fundamental problems in the analysis of partial differential equations and free boundary theory, to develop advanced mathematical theories with the possibility of important applications. The expected outcome is the establishment of a regularity and classification theory for nonlocal equations and for free boundary problems in linear and nonlinear settings. The benefit of the project lies in a concrete advancement of the mathematical research with advantages for a deeper understanding of complex phenomena in physics and biology. Some of the problems also provide results useful for industrial applications.Read moreRead less
Special Research Initiatives - Grant ID: SR0354716
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Energetically Open Systems Research Network Study. Conceptual frameworks arising in the physical sciences, such as non-equilibrium statistical mechanics and thermodynamics, synergetics, chaos and dynamical systems theory, are seminal in the emerging science of complexity. This study will lay the groundwork for a network to link Australian and overseas research on these fundamental concepts, and their application within the context of entropy-producing systems vital to the long-term sustainabilit ....Energetically Open Systems Research Network Study. Conceptual frameworks arising in the physical sciences, such as non-equilibrium statistical mechanics and thermodynamics, synergetics, chaos and dynamical systems theory, are seminal in the emerging science of complexity. This study will lay the groundwork for a network to link Australian and overseas research on these fundamental concepts, and their application within the context of entropy-producing systems vital to the long-term sustainability of the earth - oceans, atmosphere, biosphere, CO2-free energy production, space and solar environment. The network would facilitate the development of young investigators and be linked into wider complex systems networks such as the CSIRO Centre for Complex Systems Science.Read moreRead less
Fundamental mathematical structures in statistical and quantum systems. Mathematics is playing a key role in modern science and technology. This project will bring together world leading experts from Australia and the USA to unravel the most fundamental mathematical structures in of statistical and quantum systems arising in settings ranging from physics of tiny quantum dots to string theory in high energy physics. This research will ensure Australia's involvement in cutting-edge international d ....Fundamental mathematical structures in statistical and quantum systems. Mathematics is playing a key role in modern science and technology. This project will bring together world leading experts from Australia and the USA to unravel the most fundamental mathematical structures in of statistical and quantum systems arising in settings ranging from physics of tiny quantum dots to string theory in high energy physics. This research will ensure Australia's involvement in cutting-edge international developments in mathematical sciences poised to deliver new significant results in the fundamental quantum theory of matter. The project will also contribute to training young researchers to maintain Australia's international standing in fundamental science.Read moreRead less
Quantization of polyhedral surfaces. Recent developments in the theory of discrete surfaces have revealed their fascinating links to many other areas of mathematics including integrable systems and quantum geometry. Rapid progress in this field is motivated by applications in pure mathematics, mathematical physics, computer graphics and engineering. Australian researchers are world recognized experts in integrable systems and this project will link them together with German experts in discrete d ....Quantization of polyhedral surfaces. Recent developments in the theory of discrete surfaces have revealed their fascinating links to many other areas of mathematics including integrable systems and quantum geometry. Rapid progress in this field is motivated by applications in pure mathematics, mathematical physics, computer graphics and engineering. Australian researchers are world recognized experts in integrable systems and this project will link them together with German experts in discrete differential geometry. The project will advance our knowledge base in fundamental and applied sciences and offer a unique research training opportunity for students in contemporary areas of pure and applied mathematics.Read moreRead less
Diffusion driven pattern formation and signal propagation in spatially complex excitable media. A basic understanding of the mechanisms for pattern formation, from the spots on leopards to electrical signalling of neurons, has been achieved through reaction-diffusion equations. However to obtain a complete understanding, which is vital for many applications, it is necessary to modify this mathematical model to incorporate spatial complexities in the underlying media. This project will develop ....Diffusion driven pattern formation and signal propagation in spatially complex excitable media. A basic understanding of the mechanisms for pattern formation, from the spots on leopards to electrical signalling of neurons, has been achieved through reaction-diffusion equations. However to obtain a complete understanding, which is vital for many applications, it is necessary to modify this mathematical model to incorporate spatial complexities in the underlying media. This project will develop a fractional calculus framework for pattern formation, including signal propagation, in spatially complex and excitable media. In a particular application we will model the way in which the signalling properties of neurons depend critically on their spatial complexity.Read moreRead less