Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100177
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
A flexible high throughput analytical system for psychopharmacology and drug discovery. A sensitive new liquid chromatography mass spectrometer will enable a team of leading researchers to detect drugs of abuse and therapeutic drugs in the brain and body as well as levels of hormones, peptides and neurotransmitters. This will enhance a large number of projects examining new treatments for addictive disorders and mental illness.
Biased information processing in anxiety: Low anxiety scores, but still at risk. Information processing in anxious persons is biased if confronted with threatening stimulus materials such as words or pictures. This finding has considerable implications for our understanding of fear acquisition and maintenance and for the design of therapeutic interventions. More recent research has shown, however, that low anxious persons who employ repressive coping styles show similar biases. The present proj ....Biased information processing in anxiety: Low anxiety scores, but still at risk. Information processing in anxious persons is biased if confronted with threatening stimulus materials such as words or pictures. This finding has considerable implications for our understanding of fear acquisition and maintenance and for the design of therapeutic interventions. More recent research has shown, however, that low anxious persons who employ repressive coping styles show similar biases. The present project will follow up on these findings by combining the expertises of the two CIs in contemporary cognitive and psychophysiological research. It will not only provide new insights, but also offer research opportunities for postgraduate students, and prospects for future collaborative funding.Read moreRead less
Human learning of likes and dislikes: A test of the dual process account and an investigation of its neural substrates. Dual process accounts of human affective learning hold that affective learning, the learning of likes and dislikes, and relational learning, the learning of predictive relationships, reflect separate learning mechanisms. Affective learning, for instance, is said not to extinguish, a claim that has far reaching consequences for the design of behaviourally based treatments of a ....Human learning of likes and dislikes: A test of the dual process account and an investigation of its neural substrates. Dual process accounts of human affective learning hold that affective learning, the learning of likes and dislikes, and relational learning, the learning of predictive relationships, reflect separate learning mechanisms. Affective learning, for instance, is said not to extinguish, a claim that has far reaching consequences for the design of behaviourally based treatments of anxiety. The project will test this and other predictions of dual process accounts. Moreover, it will extent the experimental analysis of affective learning to the acquisition of likes and identify the cortical bases for aversive, appetitive, and relational learning using event related functional magnetic resonance imaging.Read moreRead less
RCTs on Trial: How Placebo Effects Could Undermine Double-blind RCTs. Double-blind randomised placebo-controlled trials (RCTs) are considered the gold standard for establishing treatment efficacy. However, there are both theoretical and empirical reasons to believe that they do not adequately control for the placebo effect. Cost and ethical considerations prevent researchers conducting actual double-blind RCTs with patients from exploring these issues. To address this gap, this project uses nove ....RCTs on Trial: How Placebo Effects Could Undermine Double-blind RCTs. Double-blind randomised placebo-controlled trials (RCTs) are considered the gold standard for establishing treatment efficacy. However, there are both theoretical and empirical reasons to believe that they do not adequately control for the placebo effect. Cost and ethical considerations prevent researchers conducting actual double-blind RCTs with patients from exploring these issues. To address this gap, this project uses novel experimental models to systematically test key aspects of the double-blind RCT methodology that are intended to control for the placebo effect. The project aims to provide essential data on the validity of these trials, thereby improving Australia's health and ensuring that Government treatment subsidies are well spent.Read moreRead less
Memory consolidation - Integrating cognitive science and neuroscience approaches to how we remember and how we forget. How can we forget what happened yesterday, but vividly remember our first kiss? Neuroscientists think the brain has a special mechanism to strengthen memories with time, but many psychologists disagree. The project aims to bring the brain and the mind closer together, using the cutting-edge combination of brain imaging and psychological modelling.
The regulation of desire by bodily state. Many experiences, like food, wine and sex, are pleasurable. These experiences are also desired, but less so when sated. The aim of this proposal is to understand how satiation regulates desire. We propose two memory-based models, and test them using several new experimental approaches. This is significant, not only because poorly regulated desire is linked to many social and economic ills (e.g., over-eating), but also because it is a key part of huma ....The regulation of desire by bodily state. Many experiences, like food, wine and sex, are pleasurable. These experiences are also desired, but less so when sated. The aim of this proposal is to understand how satiation regulates desire. We propose two memory-based models, and test them using several new experimental approaches. This is significant, not only because poorly regulated desire is linked to many social and economic ills (e.g., over-eating), but also because it is a key part of human motivation that is poorly understood. The expected outcome is a new theoretical model of how memory processes interact with bodily signals to generate both sated states and desire. The benefits include a new understanding of how desire is regulated and how and why this might break down.Read moreRead less
To focus on pain or not to focus: WHEN is the question. The experience of pain is a ubiquitous experience, and persistent pain is common and causes enormous personal and
societal burden. Anyone who has been in severe pain will understand that pain captures attention, but the role that attention plays in
increasing pain perception is poorly understood. This project will test a new conceptual model that calls for a change in the paradigm underlying research into attention and pain. We will use nov ....To focus on pain or not to focus: WHEN is the question. The experience of pain is a ubiquitous experience, and persistent pain is common and causes enormous personal and
societal burden. Anyone who has been in severe pain will understand that pain captures attention, but the role that attention plays in
increasing pain perception is poorly understood. This project will test a new conceptual model that calls for a change in the paradigm underlying research into attention and pain. We will use novel experimental tasks in virtual reality environments to address
these important gaps in our knowledge. The project will significantly advance our fundamental understanding of
the role of attention in pain perception and pave the way for translational research to reduce the substantial burden pain causes.Read moreRead less
Understanding psychological processes that inhibit the nocebo effect. The nocebo effect – when negative expectancies trigger adverse outcomes – causes enormous personal and societal harm. Although there have been advances in understanding some of the psychological processes underlying these effects, much less is known about how to inhibit them or the role that social learning plays in producing them. This project uses a new experimental model involving Galvanic Vestibular Stimulation to address ....Understanding psychological processes that inhibit the nocebo effect. The nocebo effect – when negative expectancies trigger adverse outcomes – causes enormous personal and societal harm. Although there have been advances in understanding some of the psychological processes underlying these effects, much less is known about how to inhibit them or the role that social learning plays in producing them. This project uses a new experimental model involving Galvanic Vestibular Stimulation to address these important gaps in our knowledge. The project will significantly advance our fundamental understanding of the nocebo effect and pave the way for translational research to reduce the substantial harm it causes.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120100562
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Investigating the evolution of human traits and the maintenance of heritable individual differences. This project will use twin studies, statistical genetics, and experimental methods to investigate genetic and environmental influences on evolutionarily relevant human traits. This will help reveal how human traits evolved and why all individuals are genetically different despite Darwinian selection favouring only the most advantageous genes.
Modelling dynamic interactive social processes. This project aims to enhance our understanding of complex social systems by developing empirically testable mathematical models for interactive, dynamic social processes. Models will be developed for such processes as the development of interpersonal and inter-organisational networks, and social influence and diffusion. They will be assessed using new and exacting evaluation techniques. The results will strengthen the mathematical foundation for ....Modelling dynamic interactive social processes. This project aims to enhance our understanding of complex social systems by developing empirically testable mathematical models for interactive, dynamic social processes. Models will be developed for such processes as the development of interpersonal and inter-organisational networks, and social influence and diffusion. They will be assessed using new and exacting evaluation techniques. The results will strengthen the mathematical foundation for modelling in the social sciences, and will have immediate application in several diverse domains, including: the structure of networks relevant to disease transmission; the social epidemiology of rural mental health; and the emergence of collective structures in organisations.Read moreRead less