Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668543
Funder
Australian Research Council
Funding Amount
$280,000.00
Summary
A high resolution, high-throughput chromatographic system for separation and characterisation of complex samples. Purchase of this equipment will support innovative and collaborative research addressing three of the National Research Priority areas. For example, defining novel drug delivery systems, or the chemical components present in Australia's bioresources, addresses 'Frontier technologies for building and transforming Australian industries', particularly the priority goals of breakthrough ....A high resolution, high-throughput chromatographic system for separation and characterisation of complex samples. Purchase of this equipment will support innovative and collaborative research addressing three of the National Research Priority areas. For example, defining novel drug delivery systems, or the chemical components present in Australia's bioresources, addresses 'Frontier technologies for building and transforming Australian industries', particularly the priority goals of breakthrough science and frontier technologies. The research into trace components in food products, and on fruit fly chemistry, relates to National Research priority four 'Safeguarding Australia', with a priority goal of protecting Australia from invasive diseases and pests. Nutraceutical research addresses the goal of 'Promoting and maintaining good health'.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668471
Funder
Australian Research Council
Funding Amount
$262,706.00
Summary
Hyphenated Capillary Electrophoresis - Mass Spectrometry Facility. The requested funding will facilitate the expansion of the activities of the University of Tasmania (UTas) node of the Australian Centre for Research on Separation Science and its collaborators. This initiative will involve the application of integrated, high resolution technologies for the separation and identification of complex chemical and biological samples. The instrument is to be shared by a number of highly research-activ ....Hyphenated Capillary Electrophoresis - Mass Spectrometry Facility. The requested funding will facilitate the expansion of the activities of the University of Tasmania (UTas) node of the Australian Centre for Research on Separation Science and its collaborators. This initiative will involve the application of integrated, high resolution technologies for the separation and identification of complex chemical and biological samples. The instrument is to be shared by a number of highly research-active groups at UTas in the fields of chemistry, biochemistry, plant and agricultural science, Antarctic studies, and pharmacy where detailed structural identification of components separated from complex mixtures is essential. These projects all focus on fundamental and applied research of great national significance.Read moreRead less
Probing the Tasmanian Devil Serum Proteome for Preclinical Diagnosis of Devil Facial Tumour Disease. The Tasmanian Devil (Sarcophilus harrisii) is a carnivorous marsupial endemic to the island state of Tasmania, and is found all over the state. Over the past decade, a dramatic decline has occurred in the Devil population in association with the emergence of Devil Facial Tumour Disease (DFTD). This project aims to develop a preclinical diagnostic test for DFTD that will provide vital information ....Probing the Tasmanian Devil Serum Proteome for Preclinical Diagnosis of Devil Facial Tumour Disease. The Tasmanian Devil (Sarcophilus harrisii) is a carnivorous marsupial endemic to the island state of Tasmania, and is found all over the state. Over the past decade, a dramatic decline has occurred in the Devil population in association with the emergence of Devil Facial Tumour Disease (DFTD). This project aims to develop a preclinical diagnostic test for DFTD that will provide vital information for use in developing management strategies to ensure the ongoing survival of the Tasmanian Devil. The benefit to Australia in performing this research rests in the new technology that will be developed and the application of this technology to key areas of national and international significance.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775725
Funder
Australian Research Council
Funding Amount
$465,000.00
Summary
Molecular separation and characterisation - A facility for advanced mass spectroscopy and chromatography. Characterising molecular composition is a basic need for the progress of many sciences. It is used to examine traditional and modern medicinal chemistry, bio-active peptides, molecular modulation of chemical properties, markers of disease and system status, and can also be used to elucidate molecular mechanisms and interactions in a system. This can only be achieved through precise measureme ....Molecular separation and characterisation - A facility for advanced mass spectroscopy and chromatography. Characterising molecular composition is a basic need for the progress of many sciences. It is used to examine traditional and modern medicinal chemistry, bio-active peptides, molecular modulation of chemical properties, markers of disease and system status, and can also be used to elucidate molecular mechanisms and interactions in a system. This can only be achieved through precise measurement using the frontier technologies described in this grant. This proposal ensures international competitiveness on a broad front, and supports highest level research training and bio/chemical/medical research in several priority research areas. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453651
Funder
Australian Research Council
Funding Amount
$907,511.00
Summary
Small Molecule NMR Facility for Accelerated Drug Discovery. This project will accelerate the drug discovery process by establishing a world-class small-molecule Nuclear Magnetic Resonance (NMR) facility. The requested instrumentation will enable high throughput structural analysis of synthetic lead compounds, expedite natural product isolation and identification and enhance NMR-based drug screening. This facility will support both existing and new programs in Victorian universities, particularly ....Small Molecule NMR Facility for Accelerated Drug Discovery. This project will accelerate the drug discovery process by establishing a world-class small-molecule Nuclear Magnetic Resonance (NMR) facility. The requested instrumentation will enable high throughput structural analysis of synthetic lead compounds, expedite natural product isolation and identification and enhance NMR-based drug screening. This facility will support both existing and new programs in Victorian universities, particularly Medicinal and Biological Chemistry, and achieve internationally competitive research capabilities. Outcomes will include the development of new pharmaceuticals, increased local and international collaboration and the training of new scientists in state-of-the-art spectroscopic techniques for identification of natural products and synthetic molecules of pharmacological importance.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883096
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Analytical and Preparative Enantioselective Chromatography. Enantiomers are forms of the same molecule that are non-superimposable mirror images of one another, like a left hand and a right hand. Because they are so similar they are very difficult to separate. However, they have very different biological properties, such as when used as drugs. One enantiomer may be beneficial while the other has no effect or sometimes is even toxic. Therefore it is important to be able to tell how much of ea ....Analytical and Preparative Enantioselective Chromatography. Enantiomers are forms of the same molecule that are non-superimposable mirror images of one another, like a left hand and a right hand. Because they are so similar they are very difficult to separate. However, they have very different biological properties, such as when used as drugs. One enantiomer may be beneficial while the other has no effect or sometimes is even toxic. Therefore it is important to be able to tell how much of each enantiomer is present in a sample and to be able to separate them. This facility will allow us to do both of these things.Read moreRead less
Mass Spectrometric Investigations of Conformation and Dynamics of Biological Complexes. The new collaboration between the leading mass spectrometry groups at University Wollongong and Cambridge University will benefit both partners. Researchers at Wollongong will have access to an ion mobility mass spectrometry technology not currently available in Australia that will contribute to our understanding of complicated cellular processes such as chromosome replication. The researchers' experience wit ....Mass Spectrometric Investigations of Conformation and Dynamics of Biological Complexes. The new collaboration between the leading mass spectrometry groups at University Wollongong and Cambridge University will benefit both partners. Researchers at Wollongong will have access to an ion mobility mass spectrometry technology not currently available in Australia that will contribute to our understanding of complicated cellular processes such as chromosome replication. The researchers' experience with this technology will pave the way for introduction of the technology to Australia and benefit the wider scientific community in wide-ranging projects such as development of new antibiotics and vaccines. Students from both institutions will benefit from experiencing science from an international perspective.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560940
Funder
Australian Research Council
Funding Amount
$229,326.00
Summary
Stable Isotope Ratio Mass Spectrometry Facility. This application for a Stable Isotope Ratio Mass Spectrometer Facility provides a focus for research collaboration and training in northern Australia. The Facility will enhance strong collaboration between organisations committed to increasing understanding of unique northern environments, and will include the Arafura Timor Research Facility, a Major National Research Facility. The Facility will contribute to studies of conservation biology, nat ....Stable Isotope Ratio Mass Spectrometry Facility. This application for a Stable Isotope Ratio Mass Spectrometer Facility provides a focus for research collaboration and training in northern Australia. The Facility will enhance strong collaboration between organisations committed to increasing understanding of unique northern environments, and will include the Arafura Timor Research Facility, a Major National Research Facility. The Facility will contribute to studies of conservation biology, natural resource management, environmental and marine science and resource development in the tropical north. It will help develop knowledge bases, innovative approaches to environmental management and sustainable development and high levels of research and research training for regional development.Read moreRead less
Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly whe ....Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly where they act in the brain. Read moreRead less
Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly whe ....Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly where they act in the brain. Read moreRead less