Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561224
Funder
Australian Research Council
Funding Amount
$267,767.00
Summary
14CHRONOS (Chronologies from High-ResolutiON Organic Separations): a centre for radiocarbon dating of specific compounds for the environmental and archaeological sciences. Accurate timekeeping is central to the environmental and archaeological sciences. Radiocarbon dating is the leading geochronological technique for events of the past 50,000 years, but the issue for sample contamination remains a major source of concern. Avoidance of contaminants can be achieved through the identification of sp ....14CHRONOS (Chronologies from High-ResolutiON Organic Separations): a centre for radiocarbon dating of specific compounds for the environmental and archaeological sciences. Accurate timekeeping is central to the environmental and archaeological sciences. Radiocarbon dating is the leading geochronological technique for events of the past 50,000 years, but the issue for sample contamination remains a major source of concern. Avoidance of contaminants can be achieved through the identification of specific biomolecular compounds that unambiguously formed part of the original sample, and the isolation of these biomolecules for radiocarbon dating using accelerator mass spectrometry. Here we request funds to establish Australia's first compound-specific radiocarbon dating facility, to obtain ages of high accuracy for key studies of climate and landscape change, evolutionary biology and archaeology.Read moreRead less
Defining the direct effects of exercise on arterial adaptation. Understanding the mechanisms responsible for the beneficial effects of exercise is fundamental to optimising the design of preventative programs aimed at healthy ageing. These experiments will contribute to our understanding of the direct effects of changes in blood flow and pressure during exercise on vascular adaptations in humans.
An inventory of past biodiversity in Western Australia using ancient DNA. Fossil bones and museum skins are genetic time capsules that facilitate the exploration of Australia's past biodiversity. Travelling back in 'genetic time' provides important insights into how ecosystems functioned prior to the arrival of Europeans and the feral species that accompanied them. This funding will facilitate research into the genetic heritage of endangered WA species such as Woylies and Cockatoos. Native speci ....An inventory of past biodiversity in Western Australia using ancient DNA. Fossil bones and museum skins are genetic time capsules that facilitate the exploration of Australia's past biodiversity. Travelling back in 'genetic time' provides important insights into how ecosystems functioned prior to the arrival of Europeans and the feral species that accompanied them. This funding will facilitate research into the genetic heritage of endangered WA species such as Woylies and Cockatoos. Native species face increasing pressures from climate change and invasive species. Compiling a genetic inventory of WA's past biodiversity will assist in developing scientifically sound conservation management responses. Such approaches are critically important if this biodiversity hotspot is to be preserved for future generations.Read moreRead less
The evolution of specialised orchid pollination and its reversibility. This project aims to determine the changes in key floral volatile compounds underpinning pollination transitions, identify their molecular basis, and understand the ecological processes favouring reversals away from extreme specialisation. By focusing on pollination of sexually deceptive Australian orchids, this project would be the first to determine the molecular, chemical and behavioural basis of evolutionary reversals to ....The evolution of specialised orchid pollination and its reversibility. This project aims to determine the changes in key floral volatile compounds underpinning pollination transitions, identify their molecular basis, and understand the ecological processes favouring reversals away from extreme specialisation. By focusing on pollination of sexually deceptive Australian orchids, this project would be the first to determine the molecular, chemical and behavioural basis of evolutionary reversals to more generalised strategies in a group of plants facing high risk of pollinator extinction. The expected outcome, a mechanistic understanding of how pollination transitions occur, would be internationally ground-breaking, and provide crucial insights to protect this diverse but highly threatened group of plants.Read moreRead less
Impact of shear stress on vascular adaptations in humans. Large arteries are important for the delivery of blood and oxygen to organs such as the heart and brain. A primary physiological stimulus which controls the size and function of these crucial arteries is the magnitude of flow or, more accurately, shear force that the inner wall of the artery is exposed to. We have developed novel software which enables non-invasive assessment of arterial wall velocity, diameter and blood flow. We will ass ....Impact of shear stress on vascular adaptations in humans. Large arteries are important for the delivery of blood and oxygen to organs such as the heart and brain. A primary physiological stimulus which controls the size and function of these crucial arteries is the magnitude of flow or, more accurately, shear force that the inner wall of the artery is exposed to. We have developed novel software which enables non-invasive assessment of arterial wall velocity, diameter and blood flow. We will assess the impact of acute and chronic changes in wall flow and shear on arterial size and function. We will also develop new software which measures other aspects of artery wall behaviour. These basic human physiology studies have direct implications for assessment of artery health in humans.Read moreRead less
Preventing and reversing population declines of northern quolls. This project seeks to develop novel effective strategies to halt and reverse declines in northern quolls by improving their ‘toad-smart’ behaviour. The spread of cane toads threaten northern quolls, which are marsupial predators. We cannot halt the toad invasion, but we can train quolls not to eat cane toads. Trained quolls can survive long term in toad-infested landscapes, and their offspring can learn not to eat toads. This proje ....Preventing and reversing population declines of northern quolls. This project seeks to develop novel effective strategies to halt and reverse declines in northern quolls by improving their ‘toad-smart’ behaviour. The spread of cane toads threaten northern quolls, which are marsupial predators. We cannot halt the toad invasion, but we can train quolls not to eat cane toads. Trained quolls can survive long term in toad-infested landscapes, and their offspring can learn not to eat toads. This project builds on this work by focusing on cultural and genetic transmission of toad-smart behaviour. The project could save numerous quoll populations from extinction.Read moreRead less
A multidisciplinary research program to assess limiting factors and predict impacts of climate change for endangered Australian orchids. Climate change poses a significant threat to biodiversity. Australian sexually deceptive orchids are dependent on obligate and specialised interactions with pollinators and fungi. Consequently, they may face a high risk of extinction if climate change uncouples these interactions. Thus orchids provide an important bio-indicator of change. The tools and expertis ....A multidisciplinary research program to assess limiting factors and predict impacts of climate change for endangered Australian orchids. Climate change poses a significant threat to biodiversity. Australian sexually deceptive orchids are dependent on obligate and specialised interactions with pollinators and fungi. Consequently, they may face a high risk of extinction if climate change uncouples these interactions. Thus orchids provide an important bio-indicator of change. The tools and expertise developed will contribute directly to the conservation of endangered Australian orchids, and will take into account the risks of climate change. The project will contribute to the priority research goals of sustainable use of Australia's biodiversity as well as responding to climate change and variability. The project will also provide high quality, cross-disciplinary training.Read moreRead less
Synthesis and evaluation of labelled germination stimulants for determining the role of butenolide in promoting seed germination. The discovery of the germination promotive agent in smoke (a butenolide) represents a major and internationally significant scientific discovery for Australia and provides exciting opportunities for benefits in agriculture, natural lands management and restoration sciences. The activity demonstrated with a broad range of species shows that the butenolide has general a ....Synthesis and evaluation of labelled germination stimulants for determining the role of butenolide in promoting seed germination. The discovery of the germination promotive agent in smoke (a butenolide) represents a major and internationally significant scientific discovery for Australia and provides exciting opportunities for benefits in agriculture, natural lands management and restoration sciences. The activity demonstrated with a broad range of species shows that the butenolide has general applicability worldwide. This study now provides a unique opportunity for Australian research to establish a world-leading position in understanding the butenolide mode of action within plant seeds which will result in a significant advance in our understanding of the processes that regulate seed dormancy in many plant species. Read moreRead less
Predicting seed lifespan for improved curation of conservation seed banks. This project aims to improve the practice of seed banking for the conservation of the Australian flora. Recent evidence points to diverse and complex storage behaviour for wild seeds and to seeds of many species being shorter-lived than anticipated. Predicting seed storage behaviour and viability decline is central to effective seedbanking. This project expects to develop new high throughput technologies and data interrog ....Predicting seed lifespan for improved curation of conservation seed banks. This project aims to improve the practice of seed banking for the conservation of the Australian flora. Recent evidence points to diverse and complex storage behaviour for wild seeds and to seeds of many species being shorter-lived than anticipated. Predicting seed storage behaviour and viability decline is central to effective seedbanking. This project expects to develop new high throughput technologies and data interrogation techniques for predicting seed lifespan in storage, and alternative storage protocols for problematic seeds. Results will allow seed bank managers to more efficiently triage and curate their seed collections and will benefit seed banks globally.Read moreRead less
Optimising disease surveillance to support decision-making. COVID-19 has demonstrated the critical role of epidemic data and analytics in guiding government response to pandemic threats, reducing disease and saving lives. The demand for epidemic analytics for response to threats of national significance will only grow. The goals of this project are to 1) determine the combination(s) of surveillance methods that provide the most useful data for epidemic analysis and 2) translate these findings in ....Optimising disease surveillance to support decision-making. COVID-19 has demonstrated the critical role of epidemic data and analytics in guiding government response to pandemic threats, reducing disease and saving lives. The demand for epidemic analytics for response to threats of national significance will only grow. The goals of this project are to 1) determine the combination(s) of surveillance methods that provide the most useful data for epidemic analysis and 2) translate these findings into the blueprint for a next-generation infectious disease surveillance system for Australia. We will use a simulation-evaluation approach, coupling methods from infectious disease modelling with those from information theory optimal design. Outcomes will enable more tailored and effective pandemic response.Read moreRead less