Expecting the unexpected: how people prioritise predictability. This project aims to investigate how people represent and use information about unpredictability in their environment. Seeing too much predictability is problematic, but seeing too little can also be a problem, for example inappropriate "learned helplessness" can occur, whereby people feel disempowered because the world is seen as random. Recent findings demonstrated a bias in fundamental learning that may maintain these inappropria ....Expecting the unexpected: how people prioritise predictability. This project aims to investigate how people represent and use information about unpredictability in their environment. Seeing too much predictability is problematic, but seeing too little can also be a problem, for example inappropriate "learned helplessness" can occur, whereby people feel disempowered because the world is seen as random. Recent findings demonstrated a bias in fundamental learning that may maintain these inappropriate beliefs about unpredictability. This bias is not anticipated by formal theories of learning. The project will investigate how this bias is brought about by first formalising a novel theory of fundamental learning and then systematically testing its assumptions.Read moreRead less
ARC Research Network for Understanding and Managing Australian Biodiversity. Biodiversity research is strong in Australia but is highly uncoordinated and, along with recent major breakthroughs in both theory and techniques, has highlighted the need for a Network to properly integrate research and focus it on the most appropriate scale. This Network aims to bring together a diverse spectrum of highly experienced and early career researchers to pool their ideas and expertise to allow them to deter ....ARC Research Network for Understanding and Managing Australian Biodiversity. Biodiversity research is strong in Australia but is highly uncoordinated and, along with recent major breakthroughs in both theory and techniques, has highlighted the need for a Network to properly integrate research and focus it on the most appropriate scale. This Network aims to bring together a diverse spectrum of highly experienced and early career researchers to pool their ideas and expertise to allow them to determine how best to describe Australia's current biodiversity and the biological and environmental history leading up to the present. A major outcome will be the ability to predict the impacts of environmental change on biodiversity to assist management decisions across Australia, with lessons of global importance.Read moreRead less
Rediscovering Aboriginal dispersal pathways. This project aims to use cutting-edge and transdisciplinary tools in partnership with Aboriginal people to rediscover deliberate prehistoric plant dispersal pathways along the Australian east coast. By working on three unrelated species with similar disjunct distributions, expected outcomes include detecting significant ‘cultural’ vegetation patterns that will challenge current assumptions about 'natural' plant distributions. New associations between ....Rediscovering Aboriginal dispersal pathways. This project aims to use cutting-edge and transdisciplinary tools in partnership with Aboriginal people to rediscover deliberate prehistoric plant dispersal pathways along the Australian east coast. By working on three unrelated species with similar disjunct distributions, expected outcomes include detecting significant ‘cultural’ vegetation patterns that will challenge current assumptions about 'natural' plant distributions. New associations between plant biogeography and deliberate Aboriginal manipulation of Australian environments will benefit cultural heritage, land management and restoration initiatives.Read moreRead less
Genomes on islands: Improving management of Australia's threatened mammals. This project aims to improve the management of endangered mammals by combining data on genomic and morphological variation with results from conservation translocations. Using new genomics methods, the project will measure the effects of small population size on genetic diversity and mutation load, in extinct as well as remnant and translocated populations. The project will monitor seven intensively managed marsupial spe ....Genomes on islands: Improving management of Australia's threatened mammals. This project aims to improve the management of endangered mammals by combining data on genomic and morphological variation with results from conservation translocations. Using new genomics methods, the project will measure the effects of small population size on genetic diversity and mutation load, in extinct as well as remnant and translocated populations. The project will monitor seven intensively managed marsupial species to better understand how to mix populations for fauna restoration projects. This project should improve methods to promote species recovery in Australia and globally.Read moreRead less
Development of Pyrrolopyrimidines as Inhibitors of ATP-Binding Proteins. This project seeks to generate analogues of natural products that have been found to be active against cancer cells and tropical parasites. The new materials produced by this project will aid in the study of biochemical processes involved in diseases such as cancer and lymphatic filariasis, thus leading the way to development of these compounds as potential treatments for such diseases.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882289
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, ( ....New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, (ii) investigating the structure(s) of lipids (fats) in cardiovascular disease and cataract, (iii) developing anticancer drugs, and (iv) development of new materials.Read moreRead less
ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. The ARC Centre for the Mathematical Analysis of Cellular Systems aims to deliver the mathematics required to compute life. The Centre will deliver innovation in computational and mathematical biology and establish in silico biology alongside in vivo and in vitro biology. These models will allow us to understand the complexity of life at the cellu ....ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. The ARC Centre for the Mathematical Analysis of Cellular Systems aims to deliver the mathematics required to compute life. The Centre will deliver innovation in computational and mathematical biology and establish in silico biology alongside in vivo and in vitro biology. These models will allow us to understand the complexity of life at the cellular level and enable new ways of combining diverse and heterogenous data. This will allow us to understand the mechanisms underlying cellular behaviour, and to apply rational design engineering methods in order to control the dynamics of biological systems. Read moreRead less
Androgen receptor: A master regulator of lipid metabolism. This project aims to understand how male sex hormones, or androgens, affect the amount and metabolism of fats in normal body tissues. By integrating our multi-disciplinary expertise in androgen action, molecular biology, metabolism and bioinformatics with novel techniques and instrumentation, this collaboration expects to generate the first detailed picture of how fat metabolism is controlled by androgens in humans, and how closely this ....Androgen receptor: A master regulator of lipid metabolism. This project aims to understand how male sex hormones, or androgens, affect the amount and metabolism of fats in normal body tissues. By integrating our multi-disciplinary expertise in androgen action, molecular biology, metabolism and bioinformatics with novel techniques and instrumentation, this collaboration expects to generate the first detailed picture of how fat metabolism is controlled by androgens in humans, and how closely this relates to mice. Expected outcomes and benefits will be a new understanding of which aspects of fat metabolism are most influenced by androgens, and an ability to anticipate potential metabolic impacts of natural or pharmacological fluctuations in androgen levels in humans, laboratory animals and livestock.Read moreRead less
Computational methods for population-size-dependent branching processes. Branching processes are the primary mathematical tool used to model populations that evolve randomly in time. Most key results in the theory are derived under the simplifying assumption that individuals reproduce and die independently of each other. However, this assumption fails in most real-life situations, in particular when the environment has limited resources or when the habitat has a restricted capacity. This project ....Computational methods for population-size-dependent branching processes. Branching processes are the primary mathematical tool used to model populations that evolve randomly in time. Most key results in the theory are derived under the simplifying assumption that individuals reproduce and die independently of each other. However, this assumption fails in most real-life situations, in particular when the environment has limited resources or when the habitat has a restricted capacity. This project aims to develop novel and effective algorithmic techniques and statistical methods for a class of branching processes with dependences. We will use these results to study significant problems in the conservation of endangered island bird populations in Oceania, and to help inform their conservation management.Read moreRead less