Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668543
Funder
Australian Research Council
Funding Amount
$280,000.00
Summary
A high resolution, high-throughput chromatographic system for separation and characterisation of complex samples. Purchase of this equipment will support innovative and collaborative research addressing three of the National Research Priority areas. For example, defining novel drug delivery systems, or the chemical components present in Australia's bioresources, addresses 'Frontier technologies for building and transforming Australian industries', particularly the priority goals of breakthrough ....A high resolution, high-throughput chromatographic system for separation and characterisation of complex samples. Purchase of this equipment will support innovative and collaborative research addressing three of the National Research Priority areas. For example, defining novel drug delivery systems, or the chemical components present in Australia's bioresources, addresses 'Frontier technologies for building and transforming Australian industries', particularly the priority goals of breakthrough science and frontier technologies. The research into trace components in food products, and on fruit fly chemistry, relates to National Research priority four 'Safeguarding Australia', with a priority goal of protecting Australia from invasive diseases and pests. Nutraceutical research addresses the goal of 'Promoting and maintaining good health'.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561169
Funder
Australian Research Council
Funding Amount
$188,000.00
Summary
Facility for multidimensional fractionation of complex biological mixtures. Acquisition of multidimensional fractionation equipment will allow researchers to separate proteins from complex mixtures, and to compare whole protein profiles of multiple samples. This will permit correlation of specific protein changes associated with infection or disease, a major focus of post-genomic programs of research. The equipment will also provide identification of the key differentiating proteins using mini ....Facility for multidimensional fractionation of complex biological mixtures. Acquisition of multidimensional fractionation equipment will allow researchers to separate proteins from complex mixtures, and to compare whole protein profiles of multiple samples. This will permit correlation of specific protein changes associated with infection or disease, a major focus of post-genomic programs of research. The equipment will also provide identification of the key differentiating proteins using minimal material. Numerous world-class projects and researchers will be able to move more rapidly and reliably from crude cell extracts to identifiable markers, and maintain their competitive positions the recognition of key targets in drug design, disease diagnosis and vaccine development.Read moreRead less
Advances in Phylogenetic Comparative Methods. An understanding of our biota is impossible without understanding evolution, and developing ways to study it. The outcomes will be useful for biologists conducting theoretically important projects: understanding how and why species have evolved to be the way they are. In addition, the research will be of use to biologists studying more applied questions, such as how to predict whether certain species are likely to become endangered, go extinct, or wh ....Advances in Phylogenetic Comparative Methods. An understanding of our biota is impossible without understanding evolution, and developing ways to study it. The outcomes will be useful for biologists conducting theoretically important projects: understanding how and why species have evolved to be the way they are. In addition, the research will be of use to biologists studying more applied questions, such as how to predict whether certain species are likely to become endangered, go extinct, or whether certain species are likely to become invasive and feral. This research will maintain Australia as a leader in evolutionary biology by cementing strong collaborations with world-leading biologists and statisticians. Read moreRead less
Biohumanities: Philosophical, Historical, and Socio-Cultural Studies of Contemporary Bioscience. Improving understanding of the meaning and implications of contemporary bioscience, especially genetics and molecular biology, through bioliterate research in the humanities and social sciences, and conversely through better assimilation of bioscience and its significance by the humanities and social sciences. The research will be conducted in close collaboration with the Australian scientific commun ....Biohumanities: Philosophical, Historical, and Socio-Cultural Studies of Contemporary Bioscience. Improving understanding of the meaning and implications of contemporary bioscience, especially genetics and molecular biology, through bioliterate research in the humanities and social sciences, and conversely through better assimilation of bioscience and its significance by the humanities and social sciences. The research will be conducted in close collaboration with the Australian scientific community and will be disseminated back to the scientific community, to the humanities and to the Australian public. The project will bring to Australia the strengths of the applicant's existing collaborations with leading research centres in this field in the USA, UK and Canada.Read moreRead less
Network structure, connectivity and wildlife disease. Emerging infectious diseases of wildlife pose threats to human health (75% of human emerging diseases are zoonotic). They also threaten biodiversity and livestock. Changes in connectivity between wildlife individuals and populations are occurring because of human activities, including globalisation, climate change and habitat destruction. Understanding how these changes in connectivity affect wildlife disease dynamics is crucial for the deve ....Network structure, connectivity and wildlife disease. Emerging infectious diseases of wildlife pose threats to human health (75% of human emerging diseases are zoonotic). They also threaten biodiversity and livestock. Changes in connectivity between wildlife individuals and populations are occurring because of human activities, including globalisation, climate change and habitat destruction. Understanding how these changes in connectivity affect wildlife disease dynamics is crucial for the development of better strategies to manage their impacts. The project will also build Australia's wider capacity to manage outbreaks of infectious diseases.Read moreRead less
Elucidating structure and function of activation-associated secreted proteins (ASPs) in blood-feeding hookworms – toward new methods of control. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links betwee ....Elucidating structure and function of activation-associated secreted proteins (ASPs) in blood-feeding hookworms – toward new methods of control. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links between basic and applied research; (3) to develop excellence in research by promoting collaborative research, resulting in a more efficient use of resources in a national and international context; (4) to enhance the skills-base in biology and biotechnology; (5) to substantially increase global visibility through quality research, leading to an increased investment in Australian science.Read moreRead less
Protein structure prediction by deep long-range learning. This project aims to address the challenging problem of protein structure prediction by developing deep long-range learning methods. The project expects to advance protein structure prediction by capturing the long-range interactions through whole sequence learning, rather than short window-based learning. Expected outcomes include next-generation machine-learning techniques for predicting one, two and three-dimensional protein structures ....Protein structure prediction by deep long-range learning. This project aims to address the challenging problem of protein structure prediction by developing deep long-range learning methods. The project expects to advance protein structure prediction by capturing the long-range interactions through whole sequence learning, rather than short window-based learning. Expected outcomes include next-generation machine-learning techniques for predicting one, two and three-dimensional protein structures from their sequences. The expected outcomes should provide significant benefits by computationally determining protein structures beyond homologous sequences, and enabling structure-based drug discovery to disease-causing protein targets previously inaccessible to biotech and pharmaceutical companies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883096
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Analytical and Preparative Enantioselective Chromatography. Enantiomers are forms of the same molecule that are non-superimposable mirror images of one another, like a left hand and a right hand. Because they are so similar they are very difficult to separate. However, they have very different biological properties, such as when used as drugs. One enantiomer may be beneficial while the other has no effect or sometimes is even toxic. Therefore it is important to be able to tell how much of ea ....Analytical and Preparative Enantioselective Chromatography. Enantiomers are forms of the same molecule that are non-superimposable mirror images of one another, like a left hand and a right hand. Because they are so similar they are very difficult to separate. However, they have very different biological properties, such as when used as drugs. One enantiomer may be beneficial while the other has no effect or sometimes is even toxic. Therefore it is important to be able to tell how much of each enantiomer is present in a sample and to be able to separate them. This facility will allow us to do both of these things.Read moreRead less
Coral Reef Fishes And The Global Decline In Reef Health: Is Biodiversity At Risk Or Resilient? Successful management and protection of marine species depends on understanding the processes that control the biodiversity of marine communities at both local and regional scales. This study will develop a general model to predict the response of reef fish communities to declining habitat structure and diversity across the tropical Pacific Ocean. Using expertise and ecological tools developed in Austr ....Coral Reef Fishes And The Global Decline In Reef Health: Is Biodiversity At Risk Or Resilient? Successful management and protection of marine species depends on understanding the processes that control the biodiversity of marine communities at both local and regional scales. This study will develop a general model to predict the response of reef fish communities to declining habitat structure and diversity across the tropical Pacific Ocean. Using expertise and ecological tools developed in Australia, and in collaboration with scientists working on the other side of the Pacific, this project will develop a broad-scale understanding of the threats to coral reefs and play a leading role in the development of marine-biodiversity management plans for Australia and neighbouring regions.Read moreRead less
The place of history in science: reassessing the Darwinian revolution. This project aims to examine how historical representations of Darwin and his revolutionary theory have influenced the shape and direction of modern evolutionary science itself. The project expects to show how certain historical assumptions about Darwin and natural selection have constrained evolutionary thinking in particular ways. Conversely, it will demonstrate how contemporary developments in evolutionary science have cha ....The place of history in science: reassessing the Darwinian revolution. This project aims to examine how historical representations of Darwin and his revolutionary theory have influenced the shape and direction of modern evolutionary science itself. The project expects to show how certain historical assumptions about Darwin and natural selection have constrained evolutionary thinking in particular ways. Conversely, it will demonstrate how contemporary developments in evolutionary science have changed historians’ understanding of the history of evolution. The expected outcomes include a new understanding of the mutual interactions between history and science, capacity building in the field of the history of science, and interdisciplinary collaborations across the biological sciences and humanities.Read moreRead less