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Enhancement Of The Anti-tumour Efficacy Of Ionising Radiation Through Inhibition Of Phosphoinositide 3-kinase
Funder
National Health and Medical Research Council
Funding Amount
$123,503.00
Summary
Radiation treatment alone is given to many cancer patients, however often it does not prevent cancers from recurring. Significant promise is offered by new drugs that target molecules which play a key role in cancer growth, and combining these drugs with radiation treatment may lead to improved patient outcomes. Understanding how these drugs enhance the anti-cancer effects of radiation is critical to selecting the most appropriate patients for treatment with this combination.
Iron And Oxidative Stress In Stable And Unstable Coronary Artery Disease
Funder
National Health and Medical Research Council
Funding Amount
$86,570.00
Summary
This PhD investigates the key roles iron and insufficient antioxidants play in worsening tissue injury during and following a heart attack, in precipitating blockages in heart arteries, and in impairing blood vessel function in those with heart disease. By using drugs to remove iron from the body, it is possible to compare the detrimental effects of iron (on tissue injury and blood vessel function) in the group treated with the medication and the group treated with placebo.
Early Childhood Caries: A Longitudinal Study Measuring The Risk And Protective Factors In Infants 1-18 Months Of Age
Funder
National Health and Medical Research Council
Funding Amount
$123,736.00
Summary
Dental decay affects 70% of Australian children, with children in rural areas being worse off. This study will describe the natural history of dental decay from birth to 18 months and will examine the environment, behaviours and biology that these infants are exposed to over time. Although families will benefit most from this research, the study contributes uniquely to our knowledge of decay in young children and will directly inform population health and targeted programs of care.
The Role Of The Metabotropic Glutamate 5 And Adenosine 2A Receptors In Methamphetamine Addiction
Funder
National Health and Medical Research Council
Funding Amount
$92,673.00
Summary
Methamphetamine (METH) is a highly addictive drug for which there are currently no effective drug therapies. This project will examine two receptors, the metabotropic glutamate 5 and adenosine 2A receptors in METH addiction. It is expected that these receptors, or their combination, may decrease the desire to self administer METH or find the drug rewarding. This study will be conducted using rodents; however, the results could identify more effective drug targets for METH addiction in humans.