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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668543
Funder
Australian Research Council
Funding Amount
$280,000.00
Summary
A high resolution, high-throughput chromatographic system for separation and characterisation of complex samples. Purchase of this equipment will support innovative and collaborative research addressing three of the National Research Priority areas. For example, defining novel drug delivery systems, or the chemical components present in Australia's bioresources, addresses 'Frontier technologies for building and transforming Australian industries', particularly the priority goals of breakthrough ....A high resolution, high-throughput chromatographic system for separation and characterisation of complex samples. Purchase of this equipment will support innovative and collaborative research addressing three of the National Research Priority areas. For example, defining novel drug delivery systems, or the chemical components present in Australia's bioresources, addresses 'Frontier technologies for building and transforming Australian industries', particularly the priority goals of breakthrough science and frontier technologies. The research into trace components in food products, and on fruit fly chemistry, relates to National Research priority four 'Safeguarding Australia', with a priority goal of protecting Australia from invasive diseases and pests. Nutraceutical research addresses the goal of 'Promoting and maintaining good health'.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668471
Funder
Australian Research Council
Funding Amount
$262,706.00
Summary
Hyphenated Capillary Electrophoresis - Mass Spectrometry Facility. The requested funding will facilitate the expansion of the activities of the University of Tasmania (UTas) node of the Australian Centre for Research on Separation Science and its collaborators. This initiative will involve the application of integrated, high resolution technologies for the separation and identification of complex chemical and biological samples. The instrument is to be shared by a number of highly research-activ ....Hyphenated Capillary Electrophoresis - Mass Spectrometry Facility. The requested funding will facilitate the expansion of the activities of the University of Tasmania (UTas) node of the Australian Centre for Research on Separation Science and its collaborators. This initiative will involve the application of integrated, high resolution technologies for the separation and identification of complex chemical and biological samples. The instrument is to be shared by a number of highly research-active groups at UTas in the fields of chemistry, biochemistry, plant and agricultural science, Antarctic studies, and pharmacy where detailed structural identification of components separated from complex mixtures is essential. These projects all focus on fundamental and applied research of great national significance.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775725
Funder
Australian Research Council
Funding Amount
$465,000.00
Summary
Molecular separation and characterisation - A facility for advanced mass spectroscopy and chromatography. Characterising molecular composition is a basic need for the progress of many sciences. It is used to examine traditional and modern medicinal chemistry, bio-active peptides, molecular modulation of chemical properties, markers of disease and system status, and can also be used to elucidate molecular mechanisms and interactions in a system. This can only be achieved through precise measureme ....Molecular separation and characterisation - A facility for advanced mass spectroscopy and chromatography. Characterising molecular composition is a basic need for the progress of many sciences. It is used to examine traditional and modern medicinal chemistry, bio-active peptides, molecular modulation of chemical properties, markers of disease and system status, and can also be used to elucidate molecular mechanisms and interactions in a system. This can only be achieved through precise measurement using the frontier technologies described in this grant. This proposal ensures international competitiveness on a broad front, and supports highest level research training and bio/chemical/medical research in several priority research areas. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561224
Funder
Australian Research Council
Funding Amount
$267,767.00
Summary
14CHRONOS (Chronologies from High-ResolutiON Organic Separations): a centre for radiocarbon dating of specific compounds for the environmental and archaeological sciences. Accurate timekeeping is central to the environmental and archaeological sciences. Radiocarbon dating is the leading geochronological technique for events of the past 50,000 years, but the issue for sample contamination remains a major source of concern. Avoidance of contaminants can be achieved through the identification of sp ....14CHRONOS (Chronologies from High-ResolutiON Organic Separations): a centre for radiocarbon dating of specific compounds for the environmental and archaeological sciences. Accurate timekeeping is central to the environmental and archaeological sciences. Radiocarbon dating is the leading geochronological technique for events of the past 50,000 years, but the issue for sample contamination remains a major source of concern. Avoidance of contaminants can be achieved through the identification of specific biomolecular compounds that unambiguously formed part of the original sample, and the isolation of these biomolecules for radiocarbon dating using accelerator mass spectrometry. Here we request funds to establish Australia's first compound-specific radiocarbon dating facility, to obtain ages of high accuracy for key studies of climate and landscape change, evolutionary biology and archaeology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882682
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
The Australasian Pollen and Spore Atlas. The results generated in this project will enhance Australian research capabilities across multiple disciplines by providing access to key knowledge of pollen and spores in our region. A unified approach to the archiving, presentation and accessibility to existing and evolving databases will provide a considerably improved context for identification and knowledge pooling of any given pollen or spore type. This will create a nexus for novel interactions be ....The Australasian Pollen and Spore Atlas. The results generated in this project will enhance Australian research capabilities across multiple disciplines by providing access to key knowledge of pollen and spores in our region. A unified approach to the archiving, presentation and accessibility to existing and evolving databases will provide a considerably improved context for identification and knowledge pooling of any given pollen or spore type. This will create a nexus for novel interactions between researchers and end users of these data from within and beyond Australia's borders.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561169
Funder
Australian Research Council
Funding Amount
$188,000.00
Summary
Facility for multidimensional fractionation of complex biological mixtures. Acquisition of multidimensional fractionation equipment will allow researchers to separate proteins from complex mixtures, and to compare whole protein profiles of multiple samples. This will permit correlation of specific protein changes associated with infection or disease, a major focus of post-genomic programs of research. The equipment will also provide identification of the key differentiating proteins using mini ....Facility for multidimensional fractionation of complex biological mixtures. Acquisition of multidimensional fractionation equipment will allow researchers to separate proteins from complex mixtures, and to compare whole protein profiles of multiple samples. This will permit correlation of specific protein changes associated with infection or disease, a major focus of post-genomic programs of research. The equipment will also provide identification of the key differentiating proteins using minimal material. Numerous world-class projects and researchers will be able to move more rapidly and reliably from crude cell extracts to identifiable markers, and maintain their competitive positions the recognition of key targets in drug design, disease diagnosis and vaccine development.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453651
Funder
Australian Research Council
Funding Amount
$907,511.00
Summary
Small Molecule NMR Facility for Accelerated Drug Discovery. This project will accelerate the drug discovery process by establishing a world-class small-molecule Nuclear Magnetic Resonance (NMR) facility. The requested instrumentation will enable high throughput structural analysis of synthetic lead compounds, expedite natural product isolation and identification and enhance NMR-based drug screening. This facility will support both existing and new programs in Victorian universities, particularly ....Small Molecule NMR Facility for Accelerated Drug Discovery. This project will accelerate the drug discovery process by establishing a world-class small-molecule Nuclear Magnetic Resonance (NMR) facility. The requested instrumentation will enable high throughput structural analysis of synthetic lead compounds, expedite natural product isolation and identification and enhance NMR-based drug screening. This facility will support both existing and new programs in Victorian universities, particularly Medicinal and Biological Chemistry, and achieve internationally competitive research capabilities. Outcomes will include the development of new pharmaceuticals, increased local and international collaboration and the training of new scientists in state-of-the-art spectroscopic techniques for identification of natural products and synthetic molecules of pharmacological importance.
Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100015
Funder
Australian Research Council
Funding Amount
$430,000.00
Summary
Australian Facility for Taphonomic Experimental Research . Australian facility for taphonomic experimental research: The aim of this project is to establish a unique Australian research facility dedicated to studying the physical, chemical, and biological processes of human decomposition. This facility will be the first of its kind in Australia and the Southern Hemisphere, drawing together a collaborative team of experts in a broad range of taphonomy disciplines. The results of the research are ....Australian Facility for Taphonomic Experimental Research . Australian facility for taphonomic experimental research: The aim of this project is to establish a unique Australian research facility dedicated to studying the physical, chemical, and biological processes of human decomposition. This facility will be the first of its kind in Australia and the Southern Hemisphere, drawing together a collaborative team of experts in a broad range of taphonomy disciplines. The results of the research are expected to advance our limited understanding of the taphonomic processes acting on remains in a natural Australian environment. The outcomes will assist police and forensic services to improve their procedures for searching, locating, recovering, and identifying missing persons, victims of homicide, and victims of disaster on both a national and international scale.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883096
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Analytical and Preparative Enantioselective Chromatography. Enantiomers are forms of the same molecule that are non-superimposable mirror images of one another, like a left hand and a right hand. Because they are so similar they are very difficult to separate. However, they have very different biological properties, such as when used as drugs. One enantiomer may be beneficial while the other has no effect or sometimes is even toxic. Therefore it is important to be able to tell how much of ea ....Analytical and Preparative Enantioselective Chromatography. Enantiomers are forms of the same molecule that are non-superimposable mirror images of one another, like a left hand and a right hand. Because they are so similar they are very difficult to separate. However, they have very different biological properties, such as when used as drugs. One enantiomer may be beneficial while the other has no effect or sometimes is even toxic. Therefore it is important to be able to tell how much of each enantiomer is present in a sample and to be able to separate them. This facility will allow us to do both of these things.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560940
Funder
Australian Research Council
Funding Amount
$229,326.00
Summary
Stable Isotope Ratio Mass Spectrometry Facility. This application for a Stable Isotope Ratio Mass Spectrometer Facility provides a focus for research collaboration and training in northern Australia. The Facility will enhance strong collaboration between organisations committed to increasing understanding of unique northern environments, and will include the Arafura Timor Research Facility, a Major National Research Facility. The Facility will contribute to studies of conservation biology, nat ....Stable Isotope Ratio Mass Spectrometry Facility. This application for a Stable Isotope Ratio Mass Spectrometer Facility provides a focus for research collaboration and training in northern Australia. The Facility will enhance strong collaboration between organisations committed to increasing understanding of unique northern environments, and will include the Arafura Timor Research Facility, a Major National Research Facility. The Facility will contribute to studies of conservation biology, natural resource management, environmental and marine science and resource development in the tropical north. It will help develop knowledge bases, innovative approaches to environmental management and sustainable development and high levels of research and research training for regional development.Read moreRead less