The ARC Earth System Science Research Network. The ARC Earth System Science Network incorporates data collectors, modellers and impacts researchers to address the impacts of climate change and variability on Human, biological and physical systems. Our capacity to adapt to changes in water availability, agricultural productivity, the likelihood of species extinctions, and risks to human health will be enhanced through the Network's use of frontier technologies. The enhanced capacity to use data a ....The ARC Earth System Science Research Network. The ARC Earth System Science Network incorporates data collectors, modellers and impacts researchers to address the impacts of climate change and variability on Human, biological and physical systems. Our capacity to adapt to changes in water availability, agricultural productivity, the likelihood of species extinctions, and risks to human health will be enhanced through the Network's use of frontier technologies. The enhanced capacity to use data and model the Earth System will allow policymakers to make more informed decisions with regard to water, biodiversity, human health, industry and agriculture sustainability; thereby enhancing the national capacity to respond to climate change and variability and securing our common interest.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453434
Funder
Australian Research Council
Funding Amount
$395,077.00
Summary
A new airborne facility for environmental, hydrological, atmospheric and oceanic research: high resolution measurement of soil moisture, temperature and salinity. This proposal seeks to establish a new national capability for airborne remote sensing of key environmental variables. It will enable high-resolution mapping of near-surface soil moisture, land surface salinity and temperature, and ocean surface salinity and temperature. It will be a new tool for hydrologic, atmospheric and oceanic r ....A new airborne facility for environmental, hydrological, atmospheric and oceanic research: high resolution measurement of soil moisture, temperature and salinity. This proposal seeks to establish a new national capability for airborne remote sensing of key environmental variables. It will enable high-resolution mapping of near-surface soil moisture, land surface salinity and temperature, and ocean surface salinity and temperature. It will be a new tool for hydrologic, atmospheric and oceanic researchers, providing unprecedented detail on characteristics critical to our understanding and management of the environment. The small instrument size and weight will enable use of a light aircraft as the observing platform, providing the national (and international) research community with an affordable tool, hitherto unavailable.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100741
Funder
Australian Research Council
Funding Amount
$342,996.00
Summary
Harnessing neural plasticity with brain stimulation. This project aims to investigate the links between the molecular mechanisms underlying brain plasticity and the effects of non-invasive brain stimulation. It will use a novel approach that integrates genetics, electrophysiology and biological modelling. Plasticity underpins all learning, memory and aging. Brain stimulation can drive plasticity in humans, but these effects are extremely difficult to harness and vary widely between people. Expec ....Harnessing neural plasticity with brain stimulation. This project aims to investigate the links between the molecular mechanisms underlying brain plasticity and the effects of non-invasive brain stimulation. It will use a novel approach that integrates genetics, electrophysiology and biological modelling. Plasticity underpins all learning, memory and aging. Brain stimulation can drive plasticity in humans, but these effects are extremely difficult to harness and vary widely between people. Expected outcomes include a critical understanding of the fundamental mechanisms governing plasticity. This will provide significant benefits such as the development of individually optimised brain stimulation protocols, enabling tailored, reliable approaches to address brain function and cognition.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453973
Funder
Australian Research Council
Funding Amount
$696,093.00
Summary
Surface Spectroscopic and Microstructure Analysis. Funding is requested for an X-ray Photoelectron Spectrometer (XPS) and an Image Plate Guinier Camera (IPGC), to update and expand capabilities in surface spectroscopic and microstructural analysis of a wide range of materials. The XPS unit, to be located at the University of SA, will replace two 18-year old XPS units at UniSA and Flinders University. The IPGC is a new and unique instrument which will be located at the University of Adelaide. The ....Surface Spectroscopic and Microstructure Analysis. Funding is requested for an X-ray Photoelectron Spectrometer (XPS) and an Image Plate Guinier Camera (IPGC), to update and expand capabilities in surface spectroscopic and microstructural analysis of a wide range of materials. The XPS unit, to be located at the University of SA, will replace two 18-year old XPS units at UniSA and Flinders University. The IPGC is a new and unique instrument which will be located at the University of Adelaide. These items will be incorporated into the SA Regional Facility, which provides seamless access to instrumentation across nodes. Applications include materials science, geological and biological research projects.Read moreRead less
Continuous tooth replacement in mammals: revealing the fundamental processes in tooth generation and movement. This project will investigate how molar teeth are made in mammals by examining the nabarlek, or little rock-wallaby, which is one of a handful of mammals that is able to regenerate new molars throughout its life. These new teeth migrate through the bone in order to move into the correct position in the mouth. By investigating two well-studied organisms, the mouse and the tammar wallaby, ....Continuous tooth replacement in mammals: revealing the fundamental processes in tooth generation and movement. This project will investigate how molar teeth are made in mammals by examining the nabarlek, or little rock-wallaby, which is one of a handful of mammals that is able to regenerate new molars throughout its life. These new teeth migrate through the bone in order to move into the correct position in the mouth. By investigating two well-studied organisms, the mouse and the tammar wallaby, as well as the nabarlek itself, the developmental processes and genes involved in molar generation and movement will be revealed. This project will integrate findings in regenerative medicine, evolutionary biology, materials engineering and palaeontology to reveal the mechanisms and origins of this astounding capability.Read moreRead less
Visualisation of latent DNA. This project aims to deliver a proof-of-concept that allows visualisation of invisible DNA (latent DNA) into a quick, inexpensive and practical DNA collection method that will lead to DNA evidence being available in more cases. It will build upon a proof-of-concept method ready for transferal to forensic casework. This will allow DNA evidence recovery technicians to improve their hit rate in recovering latent DNA from real crime items, leading to more informative DNA ....Visualisation of latent DNA. This project aims to deliver a proof-of-concept that allows visualisation of invisible DNA (latent DNA) into a quick, inexpensive and practical DNA collection method that will lead to DNA evidence being available in more cases. It will build upon a proof-of-concept method ready for transferal to forensic casework. This will allow DNA evidence recovery technicians to improve their hit rate in recovering latent DNA from real crime items, leading to more informative DNA profiles. Crime items that currently yield no genetic information will now be informative, assisting investigations of serious crimes or terrorist incidents.Read moreRead less
Coping With Pressure: Respiratory Biology of Marine Mammals. Many marine mammals undergo severe, protracted lung collapse during deep dives. They also exhibit prolonged periods of apnea during sleep. In humans, lung collapse and sleep apnea both represent severe respiratory dysfunction. Pulmonary surfactant, a complex mixture that lines the lung, stabilises the lungs in terrestrial mammals, preventing lung collapse. Here, we propose a comprehensive examination of respiratory function in marine m ....Coping With Pressure: Respiratory Biology of Marine Mammals. Many marine mammals undergo severe, protracted lung collapse during deep dives. They also exhibit prolonged periods of apnea during sleep. In humans, lung collapse and sleep apnea both represent severe respiratory dysfunction. Pulmonary surfactant, a complex mixture that lines the lung, stabilises the lungs in terrestrial mammals, preventing lung collapse. Here, we propose a comprehensive examination of respiratory function in marine mammals. This study will significantly advance our knowledge of the diving physiology of Australian marine mammals. A detailed examination of the respiratory and surfactant systems of marine mammals may also reveal adaptations that enable these animals to endure sleep apnea and lung collapse.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346895
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
A Mass Directed Molecular Resolution Laboratory. The proposed "Mass Directed Molecular Resolution Laboratory" combines an integrated suite of instrumentation housed in purpose built laboratories with technical expertise to provide an unique "one stop shop" to meet the burgeoning mass spectrometry needs of the chemical community in the Melbourne area. This truly collaborative effort will service the needs of 17 research groups with 92 PhD students and post doctoral researchers and will enhance ex ....A Mass Directed Molecular Resolution Laboratory. The proposed "Mass Directed Molecular Resolution Laboratory" combines an integrated suite of instrumentation housed in purpose built laboratories with technical expertise to provide an unique "one stop shop" to meet the burgeoning mass spectrometry needs of the chemical community in the Melbourne area. This truly collaborative effort will service the needs of 17 research groups with 92 PhD students and post doctoral researchers and will enhance existing excellence in a range of areas. Finally, the laboratory will provide opportunities to: collaborate and consult with industry; train postgraduate students in instrumentation used at the cutting edge of chemical and biochemical sciences.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775503
Funder
Australian Research Council
Funding Amount
$255,000.00
Summary
Robotics for plant genomics: Increasing throughput in plant genetic analyses. Plant genomics has direct benefit to crop improvement, especially as focussed in the applicants' laboratories. Thus, the Australian agri-food sector will benefit substantially from the acceleration in plant functional genomics that will arise from the installation of the robotics equipment described in the current application, by both underpinning more applied research and also being used directly in crop improvement p ....Robotics for plant genomics: Increasing throughput in plant genetic analyses. Plant genomics has direct benefit to crop improvement, especially as focussed in the applicants' laboratories. Thus, the Australian agri-food sector will benefit substantially from the acceleration in plant functional genomics that will arise from the installation of the robotics equipment described in the current application, by both underpinning more applied research and also being used directly in crop improvement programs such as are based at the Waite Campus. The outputs will include crops with increased tolerance to biotic and abiotic stresses, a reduced dependence on chemical inputs such as fertilisers and improved food quality, with consequent benefits to the environment and human health and nutrition.Read moreRead less
Post-translational control of cell fate decision. Deciphering the multi-layered regulation of cell fate decisions is challenging. While progress has been made in understanding the role of transcriptional regulation, the influence of post-translational modification is poorly understood. Neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4)-mediated ubiquitination is absolute necessary for sex determination, a unique model of cell fate decision where gonadal cell precurs ....Post-translational control of cell fate decision. Deciphering the multi-layered regulation of cell fate decisions is challenging. While progress has been made in understanding the role of transcriptional regulation, the influence of post-translational modification is poorly understood. Neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4)-mediated ubiquitination is absolute necessary for sex determination, a unique model of cell fate decision where gonadal cell precursors differentiate either along the male or the female pathway. Thus, this project aims to analyse in detail at which stage NEDD4 action is required and what are the crucial target proteins. This project could provide a deeper understanding of how post-translational modifications influence cell fate decisions during embryogenesis.Read moreRead less