Innovative mathematical modelling to determine incorporation of gene therapy in different cell lineages; Human Immunodeficiency Virus (HIV) as a model setting. Gene therapy is a promising therapeutic that is being developed to address genetic diseases and viral infections such as Human Immunodeficiency Virus (HIV). This project will produce mathematical models of how gene therapy delivered to one type of cell can differentiate into the desired end target and impact disease.
Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the p ....Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the patient.
The strong mathematical focus of this project, and its application to a promising approach against HIV, will place Australia at the forefront of the mathematics of gene research and contribute to the National Priority Area of Promoting and Maintaining Good Health and the Priority Goal of Preventative Healthcare.
Read moreRead less
Developing feasible in situ control of mange disease in wombats. Our goal is the development of feasible in situ control of sarcoptic mange in wombat populations. Globally important, the Sarcoptes scabiei mite infects >100 mammal species and is among the 50 most common human diseases, causing health, welfare and population impacts. This infection is treatable, and we will test a new treatment (fluralaner), develop new models to guide management, and conduct replicated field trials. This will ena ....Developing feasible in situ control of mange disease in wombats. Our goal is the development of feasible in situ control of sarcoptic mange in wombat populations. Globally important, the Sarcoptes scabiei mite infects >100 mammal species and is among the 50 most common human diseases, causing health, welfare and population impacts. This infection is treatable, and we will test a new treatment (fluralaner), develop new models to guide management, and conduct replicated field trials. This will enable science-based guidelines, advancing disease control, local eradication, and regulatory approval for wombats. Our research framework is adaptable to other mange-impacted species, and advance methods and theory for control of treatable disease in wildlife.Read moreRead less
Providing the Mathematical Foundation for an Innovative Australia within Reform Based Learning Environments. The focus of this project is the pedagogical change that The Review of Teaching and Teacher Education indicates must take place in order to lay the quantitative foundations for advancing innovation, science, technology, and mathematics, while satisfying the requirements of a reform-based learning environment. Professional learning directed at teachers' pedagogical content knowledge and be ....Providing the Mathematical Foundation for an Innovative Australia within Reform Based Learning Environments. The focus of this project is the pedagogical change that The Review of Teaching and Teacher Education indicates must take place in order to lay the quantitative foundations for advancing innovation, science, technology, and mathematics, while satisfying the requirements of a reform-based learning environment. Professional learning directed at teachers' pedagogical content knowledge and belief structures with respect to mathematics within an environment of curricular change, will be evaluated in evidence-based terms related to teacher change and student outcomes. Significance includes the context, the middle school years in rural district schools, and the influence of technology on pedagogy.Read moreRead less
Novel Mathematical Technologies for Financial Valuation and Risk. The finance industry is a key industry sector in Australia, with a highly qualified and well-paid work force. The profitability and stability of financial institutions rests in part on their ability to accurately and rapidly value innovative financial products and to quantify risk, yet many contemporary financial products are difficult to value quickly and accurately. This project will bring innovative mathematical technologies ....Novel Mathematical Technologies for Financial Valuation and Risk. The finance industry is a key industry sector in Australia, with a highly qualified and well-paid work force. The profitability and stability of financial institutions rests in part on their ability to accurately and rapidly value innovative financial products and to quantify risk, yet many contemporary financial products are difficult to value quickly and accurately. This project will bring innovative mathematical technologies to bear on complex financial problems. It has the potential to improve both the profitability and stability of Australian financial institutions, and to enhance their role regionally and internationally.Read moreRead less
Developing a Conceptual Understanding of the Measurement of Length, Area and Volume: Studies of Learning and Teaching. Early numeracy is a priority for the New South Wales Department of Education, which has recently developed a very successful, research-based program for teaching number concepts. The production of a similar program for teaching measurement has been assisted by the recent development of a Framework for Learning Measurement but held back by a lack of research on the validity of t ....Developing a Conceptual Understanding of the Measurement of Length, Area and Volume: Studies of Learning and Teaching. Early numeracy is a priority for the New South Wales Department of Education, which has recently developed a very successful, research-based program for teaching number concepts. The production of a similar program for teaching measurement has been assisted by the recent development of a Framework for Learning Measurement but held back by a lack of research on the validity of that framework. This project will provide the needed research base by studying how students' understanding of measurement concepts develops between Years 1 and 4 and by investigating the effectiveness of teaching based on the Framework. Read moreRead less
Secure and Dynamic Single Identification Systems. The expected results of the project will be frontier technologies that are essential in applications and services whose acceptance and take-up will be dependent on users' assurance of their privacy. Services, such as medical information or bank information, require a secure identification scheme. Securing such services will encourage new forms of collaboration among a wider range of users with the likely impact of a more productive global economy ....Secure and Dynamic Single Identification Systems. The expected results of the project will be frontier technologies that are essential in applications and services whose acceptance and take-up will be dependent on users' assurance of their privacy. Services, such as medical information or bank information, require a secure identification scheme. Securing such services will encourage new forms of collaboration among a wider range of users with the likely impact of a more productive global economy. This impact will be particularly emphasised in Australia with its geographically disperse population. Securing vital electronic transactions will ultimately contribute to lowering costs and increasing productivity and so creating a more competitive economy.Read moreRead less
Improving train flows with connected driver advice systems. The project aims to develop new train control theory to determine the efficient movement of multiple trains, and to demonstrate a practical system for coordinating trains, on busy intercity rail corridors. Railways around the world are now deploying driver advice systems developed by the research team and the partner organisation, TTG Transportation Technology. The project is designed to enable these systems to coordinate the movements ....Improving train flows with connected driver advice systems. The project aims to develop new train control theory to determine the efficient movement of multiple trains, and to demonstrate a practical system for coordinating trains, on busy intercity rail corridors. Railways around the world are now deploying driver advice systems developed by the research team and the partner organisation, TTG Transportation Technology. The project is designed to enable these systems to coordinate the movements of many trains on a congested rail network to improve timekeeping, smooth the flow of traffic, increase capacity and reduce energy use.Read moreRead less
Real-time scheduling of trains to control peak electricity demand. This project aims to develop new scheduling and control methods that will enable railways to reduce their demand for electricity during peak demand periods, without undue disruption to the timetable.
These new methods and systems will integrate with—and expand the capabilities of—an Australian train control system that is used by railways around the world. This will enable better management of electricity within a region and be ....Real-time scheduling of trains to control peak electricity demand. This project aims to develop new scheduling and control methods that will enable railways to reduce their demand for electricity during peak demand periods, without undue disruption to the timetable.
These new methods and systems will integrate with—and expand the capabilities of—an Australian train control system that is used by railways around the world. This will enable better management of electricity within a region and better use of renewable energy sources, with significant cost savings for railways and the wider community.Read moreRead less
The impact of endocrine disrupting compounds (EDCs) in sewage contaminated waters on aquatic biota and identification of the causative compounds. The project's aims are to determine a) the impact of endocrine disrupting compounds (EDCs) such as contraceptive pills and detergents in sewage effluent on aquatic biota; and b) which EDCs contribute to the impact. This project will provide the first comprehensive assessment of whether EDCs are causing effects in rivers downstream of sewage treatment p ....The impact of endocrine disrupting compounds (EDCs) in sewage contaminated waters on aquatic biota and identification of the causative compounds. The project's aims are to determine a) the impact of endocrine disrupting compounds (EDCs) such as contraceptive pills and detergents in sewage effluent on aquatic biota; and b) which EDCs contribute to the impact. This project will provide the first comprehensive assessment of whether EDCs are causing effects in rivers downstream of sewage treatment plants and will identify the chemicals responsible. New biological tests for detecting endocrine disruption will also be developed for research and commercial use. The findings will assist regulatory bodies and water service providers to develop appropriate legislative, management and technological strategies to minimise EDC impacts on ecosystem health.Read moreRead less