Designing microarray experiments. Microarrays are powerful tools for surveying the expression levels of many thousands of genes simultaneously. They belong to the new genomics technologies which have important applications in the biological, pharmaceutical and agricultural sciences. There are many sources of uncertainty in microarray experimentation and good statistical designs are essential for ensuring that the effects of interest to scientists are accurately and precisely measured. This Pr ....Designing microarray experiments. Microarrays are powerful tools for surveying the expression levels of many thousands of genes simultaneously. They belong to the new genomics technologies which have important applications in the biological, pharmaceutical and agricultural sciences. There are many sources of uncertainty in microarray experimentation and good statistical designs are essential for ensuring that the effects of interest to scientists are accurately and precisely measured. This Project will develop novel designs for microarray experiments and focus on the advancement of topics crucial to Australia's success in technological research.
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Duality, singular perturbations and numerical analysis in infinite dimensional linear programming problems related to problems of control of nonlinear dynamical systems. Problems of control of nonlinear dynamical systems attract continued interest of eminent researchers motivated by important applications and by the fact that analytical and/or numerical analysis of a general nonlinear control problem presents a challenging task. The outcomes of the project will be both fundamental theoretical re ....Duality, singular perturbations and numerical analysis in infinite dimensional linear programming problems related to problems of control of nonlinear dynamical systems. Problems of control of nonlinear dynamical systems attract continued interest of eminent researchers motivated by important applications and by the fact that analytical and/or numerical analysis of a general nonlinear control problem presents a challenging task. The outcomes of the project will be both fundamental theoretical results and readily applicable (linear programming based) algorithms that will equip researchers and engineers with new tools for analysis and numerical solution of nonlinear control problems (including problems that have been intractable so far). The project will further enhance Australia's international reputation in Control Theory and its Applications.
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Occupational Measures Approach to Long Run Average and Singularly Perturbed Optimal Control Problems. Problems of optimal control of long-run average and singularly perturbed systems arise in many applications. The project will lead to the development of new linear programming based techniques for analyzing these problems (including problems intractable so far) and finding their numerical solutions. The new techniques will have a potential to be further developed into software that can benefit A ....Occupational Measures Approach to Long Run Average and Singularly Perturbed Optimal Control Problems. Problems of optimal control of long-run average and singularly perturbed systems arise in many applications. The project will lead to the development of new linear programming based techniques for analyzing these problems (including problems intractable so far) and finding their numerical solutions. The new techniques will have a potential to be further developed into software that can benefit Australian industries and technologies. The proposed topic is in the focus of interest of many eminent researchers around the world and the dissemination of our results will further improve Australia's standing in the international research community. Read moreRead less
Linear programming approach to nonlinear deterministic and stochastic control problems: perturbations methods and numerical analysis. The proposed research will significantly advance knowledge by creating new analytical and numerical methods for tackling complex nonlinear control problems arising in many applications. The study's outputs will lead to a deeper understanding of fundamental issues in mathematical modelling. Collaboration with renowned researchers will further improve Australia's st ....Linear programming approach to nonlinear deterministic and stochastic control problems: perturbations methods and numerical analysis. The proposed research will significantly advance knowledge by creating new analytical and numerical methods for tackling complex nonlinear control problems arising in many applications. The study's outputs will lead to a deeper understanding of fundamental issues in mathematical modelling. Collaboration with renowned researchers will further improve Australia's standing in the international research community. Also their visits may further promote research both within and outside the host institution. In particular, lectures and seminars that they will deliver will be transmitted to Australian universities participating in the Access Grid Room Project.Read moreRead less
A comparative study of generalised solution concepts for elliptic partial differential equations using nonsmooth analysis techniques. The solution of ellpitic partial differential equations is central to science and engineering. There are a number of solution concepts, such as those of weak solutions and viscosity solutions, but the relations between these are incompletely understood. We shall investigate this major question using recent advances in optimisation theory and nonsmooth analysis. ....A comparative study of generalised solution concepts for elliptic partial differential equations using nonsmooth analysis techniques. The solution of ellpitic partial differential equations is central to science and engineering. There are a number of solution concepts, such as those of weak solutions and viscosity solutions, but the relations between these are incompletely understood. We shall investigate this major question using recent advances in optimisation theory and nonsmooth analysis. Our approach is to use various approximations and their associated second-order subdifferentials, each of which implies a generalised solution concept and associated abstract convexity. Particular attention, including computational details, will be given to equations which have very different solutions of one type from those of another.Read moreRead less
Mathematical and mechanical models in nano-engineering and nanomedicine. The major environmental problems generated from global warming and the major human health problems, like cancer and diabetes, if they are to be solved at all, will most likely be resolved making use of advances in nanobiotechnology. This proposal will position Australia as a leader in the modelling of nanodevices such as gigahertz oscillators, nano-electromagnets, nanosensors, nanosyringes and nanoporous media suitable for ....Mathematical and mechanical models in nano-engineering and nanomedicine. The major environmental problems generated from global warming and the major human health problems, like cancer and diabetes, if they are to be solved at all, will most likely be resolved making use of advances in nanobiotechnology. This proposal will position Australia as a leader in the modelling of nanodevices such as gigahertz oscillators, nano-electromagnets, nanosensors, nanosyringes and nanoporous media suitable for hydrogen storage and gas separation, which will lead to new technologies and commercial spin-offs that will be of major benefit to this country. The applicants will develop a range of topics in nano-engineering and nanomedicine, training a team that will provide the next generation of researchers in these vital areas.Read moreRead less
Saddlepoint approximation, likelihood analysis and ancestral graphs for strong and weak natural selection, genetic drift and population subdivision. Building new research strength in theoretical population genetics and related statistical techniques will enhance Australia's capability in harnessing the power of post-genomic information. Sophisticated statistical techniques that make smart use of genetic data are being developed in this project. The extent to which natural selection and migrati ....Saddlepoint approximation, likelihood analysis and ancestral graphs for strong and weak natural selection, genetic drift and population subdivision. Building new research strength in theoretical population genetics and related statistical techniques will enhance Australia's capability in harnessing the power of post-genomic information. Sophisticated statistical techniques that make smart use of genetic data are being developed in this project. The extent to which natural selection and migration affect current genetic polymorphism on a population level can be quantified using these new methods. New modeling provides a rigorous foundation with which to construct inference techniques currently beyond computational approaches to the data. Assessing selective effects on genetic mutations associated with human disease will be a consequence of this new statistical methodology.Read moreRead less
The prediction of sleep/wake behaviour based on physiological and social factors. The prevalence of shiftwork has increased in Australia over the last few decades. Shiftworkers obtain less sleep, have greater difficulty maintaining good relationships, have poorer health, and are more likely to be injured at work than others. Using the largest dataset of its kind, we will substantially contribute to understanding the relationships between work hours, sleep, performance and safety. Ultimately, the ....The prediction of sleep/wake behaviour based on physiological and social factors. The prevalence of shiftwork has increased in Australia over the last few decades. Shiftworkers obtain less sleep, have greater difficulty maintaining good relationships, have poorer health, and are more likely to be injured at work than others. Using the largest dataset of its kind, we will substantially contribute to understanding the relationships between work hours, sleep, performance and safety. Ultimately, the project will answer a question critical to workplace safety - how much time off between shifts is needed to be alert and safe at work? The project will also produce tools to help industry design fatigue-friendly rosters, improving the safety, productivity and general well-being of shiftworkers in Australia and overseas.Read moreRead less