The genomics of adaptation in Wolbachia pipientis, an emerging biocontrol agent. Australians are increasingly exposed to insect-transmitted diseases such as dengue fever. Novel biocontrol methods using the bacterium Wolbachia aim to control insect populations to reduce disease transmission. Our research will be the first to investigate genomic variation and the process of adaptation to new insect hosts in Wolbachia. The novel data and understanding of evolutionary processes we generate will be c ....The genomics of adaptation in Wolbachia pipientis, an emerging biocontrol agent. Australians are increasingly exposed to insect-transmitted diseases such as dengue fever. Novel biocontrol methods using the bacterium Wolbachia aim to control insect populations to reduce disease transmission. Our research will be the first to investigate genomic variation and the process of adaptation to new insect hosts in Wolbachia. The novel data and understanding of evolutionary processes we generate will be critical for screening bacterial biocontrol candidates and designing biocontrol release strategies. It will also strengthen the position of Australian research as a world-leader in the fusion of post-genomics and applied microbiology. Read moreRead less
Understanding the ecological effects of genetic diversity: causes, consequences and relative importance. This project will examine the effect of genetic diversity on key demographic parameters (for example, population growth rates) for organisms from three groups, including a commercially important oyster. This project provides valuable information that can be used by managers of wild and cultivated populations to minimise impacts of human activities and maximise yields.
Variable Structure Control Systems in Networked Environments. This project will be the first in the world to lay the foundation for a new theory for understanding and designing new variable structure control systems in the networked environments, which is in great need due to increasing use of shared communication networks in modern industrial systems. It will firmly place Australia at the forefront of this research by developing a cutting edge technology for improving reliability and efficiency ....Variable Structure Control Systems in Networked Environments. This project will be the first in the world to lay the foundation for a new theory for understanding and designing new variable structure control systems in the networked environments, which is in great need due to increasing use of shared communication networks in modern industrial systems. It will firmly place Australia at the forefront of this research by developing a cutting edge technology for improving reliability and efficiency of industrial variable structure control systems in the networked environments, hence resulting in cost-saving and improved productivity for industry. It will provide training for new leading researchers specialised in this new theory and technology.Read moreRead less
The social determinants of childhood injury. Child hood injury is a preventable problem of major importance. This project will provide a comprehensive, research-based policy solution that will minimise death and disability among children zero to three years of age.
My enemy’s enemy is my friend: The genetics of major plant pathogen killers. Fungi are devastating agents of crop diseases. These plant pathogens, in turn, are often parasitized by other fungi in the field. The project will focus on such interactions between powdery mildews, important pathogens of many crops and wild plants, and their common fungal parasites (Ampelomyces spp.) that have already been utilised as
biocontrol agents in crop protection. Genetic and genomic tools will be used to deter ....My enemy’s enemy is my friend: The genetics of major plant pathogen killers. Fungi are devastating agents of crop diseases. These plant pathogens, in turn, are often parasitized by other fungi in the field. The project will focus on such interactions between powdery mildews, important pathogens of many crops and wild plants, and their common fungal parasites (Ampelomyces spp.) that have already been utilised as
biocontrol agents in crop protection. Genetic and genomic tools will be used to determine if these parasites evolved by switching host from plants to plant pathogens. The project has the potential to make a ground-breaking discovery in this field, and also establish the starting point for new innovative methods to protect a wide diversity
of crops using these fungi or specific compounds derived from them.Read moreRead less
SCP/TAPS proteins of the barber’s pole worm. This integrated, collaborative project, will explore, in a targeted way, the structure and function of a key group of molecules in a socio-economically important eukaryotic pathogen and their involvement in pathogen-host interactions. Fundamental knowledge and understanding of these molecules will provide a solid foundation for understanding disease processes and finding new intervention strategies for a range of pathogens. This is crucial, given the ....SCP/TAPS proteins of the barber’s pole worm. This integrated, collaborative project, will explore, in a targeted way, the structure and function of a key group of molecules in a socio-economically important eukaryotic pathogen and their involvement in pathogen-host interactions. Fundamental knowledge and understanding of these molecules will provide a solid foundation for understanding disease processes and finding new intervention strategies for a range of pathogens. This is crucial, given the serious drug resistance problems in pathogens, and residue problems in meat, milk and the environment.Read moreRead less
Statistical methods for detection of non-coding RNAs in eukaryote genomes. Understanding how eukaryotic cells work is a major goal of 21st century biology. A crucial step will be to catalogue the functional components of eukaryotic genomes. Australian researchers must be involved in this process at an early stage, in order to maximise commercial opportunities, attract quality researchers and position ourselves for further advances. This project will make major contributions to international effo ....Statistical methods for detection of non-coding RNAs in eukaryote genomes. Understanding how eukaryotic cells work is a major goal of 21st century biology. A crucial step will be to catalogue the functional components of eukaryotic genomes. Australian researchers must be involved in this process at an early stage, in order to maximise commercial opportunities, attract quality researchers and position ourselves for further advances. This project will make major contributions to international efforts in this area, via the development of statistical methods for segmenting genomes, classification of those segments, and study of the resulting classes. In the long term, enhanced understanding of eukaryotic cells will lead to breakthroughs in biology, and to medical, pharmaceutical, agricultural and scientific advances.Read moreRead less
The roles of stress and immunocompetence in biological invasions. Invasive species pose a major threat to biodiversity worldwide; and within Australia, cane toads are widely viewed as one of the biggest such problems. Building on recent studies that reveal weakened immune systems in invasion-front toads, this project will provide a comprehensive understanding of immune responses in cane toads and native frogs, with the aim of exploiting the toads' immunocompromised state to develop new and more ....The roles of stress and immunocompetence in biological invasions. Invasive species pose a major threat to biodiversity worldwide; and within Australia, cane toads are widely viewed as one of the biggest such problems. Building on recent studies that reveal weakened immune systems in invasion-front toads, this project will provide a comprehensive understanding of immune responses in cane toads and native frogs, with the aim of exploiting the toads' immunocompromised state to develop new and more effective control measures. The project will develop a new paradigm about the roles of stress and immunity in biological invasion, applicable to the control of other invasive species and to understanding processes at work when environmental changes force species to shift their ranges.Read moreRead less
Detecting sex differences in natural selection. This project aims to develop new genomic approaches for understanding how genetic mutations can differentially affect reproductive success in males and females. Applying novel tests, this project aims to uncover previously hidden genetic conflicts between the sexes. This will provide significant benefits, such as new tools that will be broadly applicable to the wider research community, and help to answer key questions in genetics and evolutionary ....Detecting sex differences in natural selection. This project aims to develop new genomic approaches for understanding how genetic mutations can differentially affect reproductive success in males and females. Applying novel tests, this project aims to uncover previously hidden genetic conflicts between the sexes. This will provide significant benefits, such as new tools that will be broadly applicable to the wider research community, and help to answer key questions in genetics and evolutionary biology in the current genomic era.Read moreRead less
Statistical Methods for Discovering Ribonucleic acids (RNAs) contributing to human diseases and phenotypes. Identifying the causative genetic factors involved in quantitative phenotypes and diseases is a major goal of biology in the 21st century and beyond. A crucial step towards this goal is identifying and classifying the functional non-protein-coding Ribonucleic acids (RNAs) encoded in the human genome. This project will make major contributions to international efforts in this area by identi ....Statistical Methods for Discovering Ribonucleic acids (RNAs) contributing to human diseases and phenotypes. Identifying the causative genetic factors involved in quantitative phenotypes and diseases is a major goal of biology in the 21st century and beyond. A crucial step towards this goal is identifying and classifying the functional non-protein-coding Ribonucleic acids (RNAs) encoded in the human genome. This project will make major contributions to international efforts in this area by identifying RNA molecules that contribute to quantitative phenotypes including susceptibility to disease. As such, it will directly benefit fundamental science via the discovery and classification of new molecules. Indirectly, it will lead to breakthroughs in biology, and consequently to major medical and pharmaceutical advances in the diagnosis and treatment of genetic disease.Read moreRead less