Subcortical control of human reaching? This project will test a radical new hypothesis about how the human brain generates visually guided behaviour. Conventional thinking assumes that visuomotor control of limb movements occurs exclusively within the cerebral cortex. However, the project team’s recent observations of extremely rapid visually guided muscle activity strongly imply that the human brain controls reaching movements via more primitive midbrain and brainstem structures. The project’s ....Subcortical control of human reaching? This project will test a radical new hypothesis about how the human brain generates visually guided behaviour. Conventional thinking assumes that visuomotor control of limb movements occurs exclusively within the cerebral cortex. However, the project team’s recent observations of extremely rapid visually guided muscle activity strongly imply that the human brain controls reaching movements via more primitive midbrain and brainstem structures. The project’s hypotheses challenge long-standing ideas about the functional organisation of the human brain and may have wide-ranging implications for the design of human-machine interfaces as well as training protocols in rehabilitation, industry, and sport.Read moreRead less
How do past actions and rewards bias goal directed movement? This project aims to identify how different aspects of our past experience affect the accuracy of movements, and study the underlying brain mechanisms. This project will use timing methods and brain recordings to test how the history of movements we have executed in the past, and the rewards associated with those movements, interact to affect subsequent movement execution. The project should advance basic understanding of how the human ....How do past actions and rewards bias goal directed movement? This project aims to identify how different aspects of our past experience affect the accuracy of movements, and study the underlying brain mechanisms. This project will use timing methods and brain recordings to test how the history of movements we have executed in the past, and the rewards associated with those movements, interact to affect subsequent movement execution. The project should advance basic understanding of how the human brain controls movement, and provide theoretical foundations needed to improve the design of human-machine interfaces, and training approaches in industry, rehabilitation and sport.Read moreRead less
Efficient strategies for visually guided flight: from insects to drones. Flying in real environments, that are densely cluttered with obstacles, is a major challenge limiting the proliferation of aerial robotic technology yet flying insects such as honeybees accomplish this task with ease. This project will seek to uncover the salient vision-based flight-control strategies implemented by insects to deal with clutter. These will be used to develop sensory and information processing frameworks for ....Efficient strategies for visually guided flight: from insects to drones. Flying in real environments, that are densely cluttered with obstacles, is a major challenge limiting the proliferation of aerial robotic technology yet flying insects such as honeybees accomplish this task with ease. This project will seek to uncover the salient vision-based flight-control strategies implemented by insects to deal with clutter. These will be used to develop sensory and information processing frameworks for implementation in miniature robotic systems which will allow them to navigate autonomously in complex environments even when GPS positioning is denied. Such capabilities will expand the operational domain and potential applications for small autonomous vehicles while improving our knowledge of insect locomotion.Read moreRead less
Viral and host RNA methylation in mosquitoes. Mosquitoes transmit a variety of viruses to humans and animals through blood feeding. This project aims to investigate one of the most common modifications of RNA molecules, known as N6-methyladenosine (m6A), in an important mosquito vector, Aedes aegypti, and its alterations upon infection with pathogenic as well as mosquito-specific viruses. In addition, m6A modification of viral genomic RNA and its importance in virus replication will be investiga ....Viral and host RNA methylation in mosquitoes. Mosquitoes transmit a variety of viruses to humans and animals through blood feeding. This project aims to investigate one of the most common modifications of RNA molecules, known as N6-methyladenosine (m6A), in an important mosquito vector, Aedes aegypti, and its alterations upon infection with pathogenic as well as mosquito-specific viruses. In addition, m6A modification of viral genomic RNA and its importance in virus replication will be investigated. Expected outcomes of this project include fundamental understanding of RNA methylation in mosquitoes and their role in mosquito biology and virus replication.Read moreRead less
Structural and neural determinants of stress and strain in human muscle. This project aims to further our understanding of the biomechanical stress and strains experienced by contracting human muscles. Using innovative imaging techniques such as microendoscopy and supersonic shear imaging, we expect to generate new significant evidence on the structural and neural factors that lead to areas of high stress in human muscles. Outcomes of this project include not only a new understanding of muscle d ....Structural and neural determinants of stress and strain in human muscle. This project aims to further our understanding of the biomechanical stress and strains experienced by contracting human muscles. Using innovative imaging techniques such as microendoscopy and supersonic shear imaging, we expect to generate new significant evidence on the structural and neural factors that lead to areas of high stress in human muscles. Outcomes of this project include not only a new understanding of muscle design on multi-scale level, but also of muscle function and adaptation. This should provide significant benefits in better predicting muscle injury and prescribing safe exercise, knowledge that would benefit biomechanical engineers and sport and exercise professionals.Read moreRead less
Understanding mosquito smell system: a new frontier in mosquito control. This project aims to identify and functionally investigate mosquito smell receptors, which are critical in detecting volatile compounds and locating their hosts from a considerable distance away. Mosquitoes display preferences for certain hosts over others, primarily determined by volatile chemicals produced by hosts. This study builds on recently discovered, novel, host-derived volatile compounds, which can elicit robust r ....Understanding mosquito smell system: a new frontier in mosquito control. This project aims to identify and functionally investigate mosquito smell receptors, which are critical in detecting volatile compounds and locating their hosts from a considerable distance away. Mosquitoes display preferences for certain hosts over others, primarily determined by volatile chemicals produced by hosts. This study builds on recently discovered, novel, host-derived volatile compounds, which can elicit robust responses and attractiveness from mosquitoes. Expected outcomes of the project are enhanced understanding of mosquito smell system and behaviours. This could provide significant benefits to how we can fight mosquitoes and mosquito-transmitted diseases in a more efficient and environmentally responsible way.Read moreRead less
A novel approach in understanding regulation of development in mosquitoes. This project aims to explore the role of microRNAs in regulation of the synthesis of a key hormone, juvenile hormone, involved in mosquito development and reproductive maturation. The development of novel approaches in mosquito control or inhibition of transmission are urgently required to combat against mosquito-borne pathogens. One such approach is to interrupt the reproduction or reduce the fitness of mosquitoes. This ....A novel approach in understanding regulation of development in mosquitoes. This project aims to explore the role of microRNAs in regulation of the synthesis of a key hormone, juvenile hormone, involved in mosquito development and reproductive maturation. The development of novel approaches in mosquito control or inhibition of transmission are urgently required to combat against mosquito-borne pathogens. One such approach is to interrupt the reproduction or reduce the fitness of mosquitoes. This project will increase our understanding of the regulation of mosquito reproduction and development, but also lead to the discovery of potential target molecules to interfere with mosquito reproduction/development.Read moreRead less
My enemy’s enemy is my friend: The genetics of major plant pathogen killers. Fungi are devastating agents of crop diseases. These plant pathogens, in turn, are often parasitized by other fungi in the field. The project will focus on such interactions between powdery mildews, important pathogens of many crops and wild plants, and their common fungal parasites (Ampelomyces spp.) that have already been utilised as
biocontrol agents in crop protection. Genetic and genomic tools will be used to deter ....My enemy’s enemy is my friend: The genetics of major plant pathogen killers. Fungi are devastating agents of crop diseases. These plant pathogens, in turn, are often parasitized by other fungi in the field. The project will focus on such interactions between powdery mildews, important pathogens of many crops and wild plants, and their common fungal parasites (Ampelomyces spp.) that have already been utilised as
biocontrol agents in crop protection. Genetic and genomic tools will be used to determine if these parasites evolved by switching host from plants to plant pathogens. The project has the potential to make a ground-breaking discovery in this field, and also establish the starting point for new innovative methods to protect a wide diversity
of crops using these fungi or specific compounds derived from them.Read moreRead less
YhcB, a crucial player in the control of bacterial cell envelope biogenesis. All life depends on a cell envelope to enclose the chemical reactions that make life possible. But how do cell envelopes grow? How each component of the cell envelope is incorporated into the envelope at the right amount and in the right time to prevent cell death, has been a longstanding question in bacteriology. Using a unique combination of high through put genetic screens and biochemical approaches, this project wil ....YhcB, a crucial player in the control of bacterial cell envelope biogenesis. All life depends on a cell envelope to enclose the chemical reactions that make life possible. But how do cell envelopes grow? How each component of the cell envelope is incorporated into the envelope at the right amount and in the right time to prevent cell death, has been a longstanding question in bacteriology. Using a unique combination of high through put genetic screens and biochemical approaches, this project will characterise a key regulator of cell envelope growth in Gram-negative bacteria. Knowledge arising from this research will provide insight into a fundamental process in bacteria, will develop new technology to probe protein interactions, and will provide novel avenues to solve infection in plants, humans and animals.Read moreRead less
Elucidating the molecular basis of plant potyvirus resistance . Plant viruses are responsible for a large proportion of crop losses, and genetic resistance is currently the most effective means to control viral spread. This project investigates, on a molecular and structural level, host factors that plant viruses hijack during infection, and in particular, the mutations in these factors that confer resistance. We further aim to elucidate the mechanisms by which plant viruses overcome resistance ....Elucidating the molecular basis of plant potyvirus resistance . Plant viruses are responsible for a large proportion of crop losses, and genetic resistance is currently the most effective means to control viral spread. This project investigates, on a molecular and structural level, host factors that plant viruses hijack during infection, and in particular, the mutations in these factors that confer resistance. We further aim to elucidate the mechanisms by which plant viruses overcome resistance mediated by these host factors. A detailed understanding of the molecular interactions between plant viruses and their host will enable new, robust and more effective forms of resistance to be engineered. This work therefore has economic and environmental implications for agricultural productivity in Australia. Read moreRead less