Developing Interpretable Machine Learning Models For Clinical Imaging And Single-cell Genomics
Funder
National Health and Medical Research Council
Funding Amount
$1,312,250.00
Summary
Machine learning methods will be vital to make best use of the deluge of data generated by high-throughput technologies in biomedical science. To get the most out of these models, however, we need to be able to unpack the 'black box'. I will use curated clinical and public research data to benchmark and develop interpretable deep learning models and software tools. These models will be used for breast cancer screening programs and for analysis of complex, large-scale single-cell genomics data.
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Industrial Transformation Research Hubs - Grant ID: IH170100013
Funder
Australian Research Council
Funding Amount
$2,962,655.00
Summary
ARC Research Hub for Digital Enhanced Living. The ARC Research Hub for Digital Enhanced Living aims to address the growing challenges of aging people living in their own home or residential care. This will be through inventing new personalised medical technologies through an innovative approach, with a multi-disciplinary team leveraging diverse expertise. An enhanced capacity to create and deploy fit-for-purpose personalised health solutions will result in revenues from new and repurposed device ....ARC Research Hub for Digital Enhanced Living. The ARC Research Hub for Digital Enhanced Living aims to address the growing challenges of aging people living in their own home or residential care. This will be through inventing new personalised medical technologies through an innovative approach, with a multi-disciplinary team leveraging diverse expertise. An enhanced capacity to create and deploy fit-for-purpose personalised health solutions will result in revenues from new and repurposed devices, analytics and integration platforms. New jobs and improved care will see cost reductions, better use of resources and enhanced mental, physical and social well-being.Read moreRead less
Identification Of Glaucoma Susceptibility Variants By Exome Sequencing In Extended Pedigrees Showing Prior Evidence Of Gene Segregation.
Funder
National Health and Medical Research Council
Funding Amount
$694,002.00
Summary
Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for tr ....Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for treatment or diagnosis.Read moreRead less
Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying ....Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying regulators of lipid metabolism. The large diversity in humans necessitate sufficient sample sizes to identify true genetic regulators, but to date techniques capturing phenotypic data (lipids) have been largely limited. It is anticipated that this study will identify new regulators of lipid metabolism in humans.Read moreRead less
Secure Management of Internet of Things Data for Critical Surveillance. This project aims to develop innovative models/algorithms to manage Internet of Things (IoT) data safely and reliably. This project expects to generate new knowledge in the area of classified information governance using innovative data collection, transmission and analysis techniques that overcome the security concerns in large-scale collaborative sensing. Expected outcomes include novel abstract interfaces for IoT, adaptiv ....Secure Management of Internet of Things Data for Critical Surveillance. This project aims to develop innovative models/algorithms to manage Internet of Things (IoT) data safely and reliably. This project expects to generate new knowledge in the area of classified information governance using innovative data collection, transmission and analysis techniques that overcome the security concerns in large-scale collaborative sensing. Expected outcomes include novel abstract interfaces for IoT, adaptive trust and integrity preserving methods, and reliable distributed data processing mechanisms to mitigate vulnerabilities in real-time IoT-enabled critical surveillance. This should provide significant benefits to Australia's economy, one of which is the enhanced consumer-centric adoption of IoT for sensitive operations.Read moreRead less
Tools, methodologies and reasoning support for developing companion-toy modules. This project investigates building of modules for an intelligent Toy which can be customised and adapted over time by add-on modules. Intelligent interactive toys are growing in popularity, and the ability for such a toy to develop over a prolonged lifetime, is both a sound business idea and a mechanism for extending the useful life of the Toy.
Preventing Exfiltration of Sensitive Data by Malicious Insiders or Malwares. Data exfiltration is a serious threat as highlighted in recent leakage of sensitive data that resulted in huge economic losses as well as unprecedented breaches of national security. The aim of this project is to develop a comprehensive and robust solution for detection and prevention of sensitive data exfiltration attempts by malware and unauthorised human users. Expected outcomes include scalable monitoring methods an ....Preventing Exfiltration of Sensitive Data by Malicious Insiders or Malwares. Data exfiltration is a serious threat as highlighted in recent leakage of sensitive data that resulted in huge economic losses as well as unprecedented breaches of national security. The aim of this project is to develop a comprehensive and robust solution for detection and prevention of sensitive data exfiltration attempts by malware and unauthorised human users. Expected outcomes include scalable monitoring methods and efficient algorithms that will be able to prevent real-time exfiltration and identify previously undetected exfiltration of sensitive data. This should provide significant benefits to governments, defence networks as well as businesses and health sectors, as it will protect them from sophisticated cyber attacks.
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Assistive technologies for autism support harnessing social media. This project aims to tap social media to revolutionize early intervention therapy for children with autism. By creating open, extensible software for therapy delivery, and tools for parents to access high quality information and support, we will provide children a greater chance to achieve their potential and much-needed relief for parents and carers.
A deep survey for compact structure in the nearby universe: key science for the upgraded Australian Long Baseline Array. This project uses advances in ICT to build a national and international network of facilities that includes existing telescopes primarily on the east coast of Australia, as well as planned facilities in Western Australia and New Zealand. One of these facilities, the New Technology Demonstrator, is a crucial part of Australia's roadmap to the Square Kilometre Array. The SKA-r ....A deep survey for compact structure in the nearby universe: key science for the upgraded Australian Long Baseline Array. This project uses advances in ICT to build a national and international network of facilities that includes existing telescopes primarily on the east coast of Australia, as well as planned facilities in Western Australia and New Zealand. One of these facilities, the New Technology Demonstrator, is a crucial part of Australia's roadmap to the Square Kilometre Array. The SKA-related science and technology demonstrations we will undertake as part of this project will contribute to Australia's bid to host this $US1b instrument. This project cements a significant Trans-Tasman collaboration and brings together researchers in astrophysics and ICT to give Australia a leading position in the field of eVLBI.Read moreRead less