Searching for near-exact protein models. This project aims to develop novel and efficient heuristic-based algorithms leading to near accurate protein tertiary structure models. Knowledge about protein structures is fundamental to our understanding of living systems. The progress on experimental determination of these structures has been extremely limited and remains an open challenge in molecular biology. Computational prediction of protein structures from sequences is emerging as a promising ap ....Searching for near-exact protein models. This project aims to develop novel and efficient heuristic-based algorithms leading to near accurate protein tertiary structure models. Knowledge about protein structures is fundamental to our understanding of living systems. The progress on experimental determination of these structures has been extremely limited and remains an open challenge in molecular biology. Computational prediction of protein structures from sequences is emerging as a promising approach, but its accuracy is far from satisfactory. The software systems developed in this project will be used in structural identification of target proteins in drug design. This will make drug design process more efficient, saving time and cost, potentially saving lives.Read moreRead less
Real-time phylogenetics for food-borne outbreak surveillance. The project aims to introduce, for the first time, real-time evolutionary analysis of agricultural pathogens so that outbreaks affecting crops and the food supply can be managed precisely and rapidly. An expert team will implement a large-scale data analytics framework in user-friendly software that integrates Australian infectious disease genomics data with global data. Underpinning this work are new theory and algorithms that apply ....Real-time phylogenetics for food-borne outbreak surveillance. The project aims to introduce, for the first time, real-time evolutionary analysis of agricultural pathogens so that outbreaks affecting crops and the food supply can be managed precisely and rapidly. An expert team will implement a large-scale data analytics framework in user-friendly software that integrates Australian infectious disease genomics data with global data. Underpinning this work are new theory and algorithms that apply Sequential Monte Carlo to update phylogenetic analyses continuously as new data arrives. Expected outcomes include new knowledge of statistical algorithms for evolutionary analysis, relevant to biological disciplines beyond infectious disease; and enhanced capacity for infectious disease analysis. Read moreRead less
Eat and Dream: effective automatic testing and debugging for real-life embedded wireless communications software. Embedded software is a key enabling technology for the majority of Australian manufacturing industries, including strategically important sectors such as the automotive industry. Embedded wireless communication technologies are playing an increasingly significant role in Australia with a wide range of critical applications ranging from natural disaster early warning to personal healt ....Eat and Dream: effective automatic testing and debugging for real-life embedded wireless communications software. Embedded software is a key enabling technology for the majority of Australian manufacturing industries, including strategically important sectors such as the automotive industry. Embedded wireless communication technologies are playing an increasingly significant role in Australia with a wide range of critical applications ranging from natural disaster early warning to personal health monitoring. Embedded wireless communications software, however, is difficult to test and debug owing to the complexity of the operational environment and complications arising from the interplay between software and hardware. This project will develop an effective and automatic technology to alleviate these difficulties and achieve higher quality software.Read moreRead less
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water ....Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water and soil should lead to deeper understanding of the dynamics, variation and transfer of genetic material within these resources’ microbial communities, strategies to manage microbial diversity, and improved productivity and long-term sustainability for these resources.Read moreRead less
THE DEVELOPMENT OF MECHANISTIC MODELS FOR BUBBLY FLOWS WITH HEAT AND MASS TRANSFER. Commercially available CFD computer codes are currently widely used in many Australian industrial sectors. It is clearly recognised that the state-of-the-art models for dealing with complex bubbly flows with/without heat and mass transfer in these computer codes require further developments and improvements. This research project will address the prevalent deficiency in many of these computer codes. It is antici ....THE DEVELOPMENT OF MECHANISTIC MODELS FOR BUBBLY FLOWS WITH HEAT AND MASS TRANSFER. Commercially available CFD computer codes are currently widely used in many Australian industrial sectors. It is clearly recognised that the state-of-the-art models for dealing with complex bubbly flows with/without heat and mass transfer in these computer codes require further developments and improvements. This research project will address the prevalent deficiency in many of these computer codes. It is anticipated that through this major development of new models capable of predicting a wide range of industrial bubbly flow problems and implementation thereafter in these computer codes, industries will experience significant benefits especially reduce time and costs in their design and production.Read moreRead less
Experimental and Numerical Modelling of Gas-Liquid Flows. Multiphase flow systems are encountered in many process industries such as chemical, petroleum, mining, energy, food and pharmaceutical, which are fundamental to the Australian economy. Commercially available computer codes for simulating such systems are currently widely used in many Australian industrial sectors. This research project will address the prevalent deficiency in many of these computer codes and develop new models capable of ....Experimental and Numerical Modelling of Gas-Liquid Flows. Multiphase flow systems are encountered in many process industries such as chemical, petroleum, mining, energy, food and pharmaceutical, which are fundamental to the Australian economy. Commercially available computer codes for simulating such systems are currently widely used in many Australian industrial sectors. This research project will address the prevalent deficiency in many of these computer codes and develop new models capable of predicting a wide range of industrial bubbly flow problems. The resultant improved computer codes will provide industries with significant benefits - especially reduced times and costs in their design and production.Read moreRead less
Intelligent Incident Management for Software-Intensive Systems. This project aims to develop intelligent incident management methods for software-intensive systems. Incidents are unplanned system interruptions or outages that could affect the normal operations of an organization and cause huge economic loss. This project expects to develop innovative, Artificial Intelligence (AI) based methods for automated incident management, including incident detection, incident identification, and incident ....Intelligent Incident Management for Software-Intensive Systems. This project aims to develop intelligent incident management methods for software-intensive systems. Incidents are unplanned system interruptions or outages that could affect the normal operations of an organization and cause huge economic loss. This project expects to develop innovative, Artificial Intelligence (AI) based methods for automated incident management, including incident detection, incident identification, and incident triage. Expected outcomes of the project include a set of novel methods and tools that can facilitate incident diagnosis and resolution. This project will provide significant benefits, such as improving the availability of software-intensive systems and reducing the economic loss caused by the incidents. Read moreRead less
Effective software vulnerability detection for web services. This project aims to design and implement new and better methods to find vulnerabilities in software services delivered over the web or through the cloud, as well as methods for proving the absence of certain types of vulnerability. So-called injection attacks are pervasive and generally considered the most important security threat on today's Internet. The programming languages used for software services tend to use strings as a unive ....Effective software vulnerability detection for web services. This project aims to design and implement new and better methods to find vulnerabilities in software services delivered over the web or through the cloud, as well as methods for proving the absence of certain types of vulnerability. So-called injection attacks are pervasive and generally considered the most important security threat on today's Internet. The programming languages used for software services tend to use strings as a universal data structure, which unfortunately makes it hard to separate trusted code from untrusted user-provided data. This project intends to develop novel program analysis tools and string constraint solvers, and employ these tools to support sophisticated automated reasoning about string manipulating software.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH170100013
Funder
Australian Research Council
Funding Amount
$2,962,655.00
Summary
ARC Research Hub for Digital Enhanced Living. The ARC Research Hub for Digital Enhanced Living aims to address the growing challenges of aging people living in their own home or residential care. This will be through inventing new personalised medical technologies through an innovative approach, with a multi-disciplinary team leveraging diverse expertise. An enhanced capacity to create and deploy fit-for-purpose personalised health solutions will result in revenues from new and repurposed device ....ARC Research Hub for Digital Enhanced Living. The ARC Research Hub for Digital Enhanced Living aims to address the growing challenges of aging people living in their own home or residential care. This will be through inventing new personalised medical technologies through an innovative approach, with a multi-disciplinary team leveraging diverse expertise. An enhanced capacity to create and deploy fit-for-purpose personalised health solutions will result in revenues from new and repurposed devices, analytics and integration platforms. New jobs and improved care will see cost reductions, better use of resources and enhanced mental, physical and social well-being.Read moreRead less