Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Finding and exploiting interesting paths in multidimensional information spaces. This project will invent a new approach for searching within a large complex information space, finding interesting paths between points within the space, visualising the results, and supporting rich, human-centric user interaction with queries and results. This project will embody these techniques in a novel, internet-scale framework to support rapid development of large path search and visualisation applications. ....Finding and exploiting interesting paths in multidimensional information spaces. This project will invent a new approach for searching within a large complex information space, finding interesting paths between points within the space, visualising the results, and supporting rich, human-centric user interaction with queries and results. This project will embody these techniques in a novel, internet-scale framework to support rapid development of large path search and visualisation applications. Evaluation will be via development of several exemplar applications. The techniques and framework will be applicable to a broad range of economically important problems in areas as diverse as health, travel, scientific publication search, product marketing and software engineering.Read moreRead less
MemberGuard: Protecting Machine Learning Privacy from Membership Inference. Machine Learning has become a core part of many real-world applications. However, machine learning models are vulnerable to membership inference attacks. In these attacks, an adversary can infer if a given data record has been part of the model's training data. In this project, the team aims to develop new techniques that can be used to counter these attacks, such as 1) new analytical models for membership leakage, 2) ne ....MemberGuard: Protecting Machine Learning Privacy from Membership Inference. Machine Learning has become a core part of many real-world applications. However, machine learning models are vulnerable to membership inference attacks. In these attacks, an adversary can infer if a given data record has been part of the model's training data. In this project, the team aims to develop new techniques that can be used to counter these attacks, such as 1) new analytical models for membership leakage, 2) new methods for susceptibility diagnosis, 3) new defences that leverage privacy and utility. Data-oriented services are estimated to be valuable assets in the future. These techniques can help Australia gain cutting edge advantage in machine learning security and privacy and protect its intellectual property on these services.Read moreRead less
Privacy-preserving data processing on the cloud. This project aims to address the current lack of privacy of user data processed by common cloud computing web servers, including email, business data, and confidential files. This project aims to develop new techniques in cryptography. The anticipated outcome is a suite of practical tools enabling common cloud computing processing operations such as search, statistical analysis, and multi-user access control, to be performed efficiently while pres ....Privacy-preserving data processing on the cloud. This project aims to address the current lack of privacy of user data processed by common cloud computing web servers, including email, business data, and confidential files. This project aims to develop new techniques in cryptography. The anticipated outcome is a suite of practical tools enabling common cloud computing processing operations such as search, statistical analysis, and multi-user access control, to be performed efficiently while preserving the data privacy. These tools should provide significant benefits to the privacy of cloud users, as well as financial and reputation benefits to the IT industry, by significantly reducing the likelihood of massive user data privacy breaches in the event of a cyber-hacking attack on the cloud server.Read moreRead less
How enhancers regulate T cell differentiation and function. This project aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for effective immune cell differentiation. Adaptive immune cell activation starts a programme of differentiation that acquires and maintains lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics, targeted genome editing and nanotechnology, ....How enhancers regulate T cell differentiation and function. This project aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for effective immune cell differentiation. Adaptive immune cell activation starts a programme of differentiation that acquires and maintains lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics, targeted genome editing and nanotechnology, this project expects to provide insights into non-coding regulatory element reprogramming and control of immune cell function and memory with implications for understanding general cellular differentiation.Read moreRead less
Special Research Initiatives - Grant ID: SR0354693
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian e-Research Grid. The e-Research Grid program will research and implement core Grid technologies on APAC and partner's deployed HPC resources, to underpin a broad range of Australian research. The computer science CIs will form collaborative links with international programs, adapting developments to local circumstances. The applications-domain CIs will leverage those into their scientific simulations and databases, using grid integrative techniques and portals. Many CIs participate in ....Australian e-Research Grid. The e-Research Grid program will research and implement core Grid technologies on APAC and partner's deployed HPC resources, to underpin a broad range of Australian research. The computer science CIs will form collaborative links with international programs, adapting developments to local circumstances. The applications-domain CIs will leverage those into their scientific simulations and databases, using grid integrative techniques and portals. Many CIs participate in other RNs linking to their motivating applications, enhancing prospects for research and integration. They participate in the APAC Grid program, leveraging 75 HPC staff nationally. A key aim is interoperability with "real-world Grids": eg e-learning & e-health programs.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989347
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
CYCLOPS - A Better Way to Find Extrasolar Planets. The primary scientific driver for this new facility is the search for planets orbiting other stars. Australian astronomers, and the Anglo-Australian Telescope, have played a leading role in this new frontier for astronomy, detecting 25 of the 250-odd extrasolar planets known to orbit nearby stars. The CYCLOPS project brings together a team of leading Australian astronomers to build on this track record with a new facility that further advances A ....CYCLOPS - A Better Way to Find Extrasolar Planets. The primary scientific driver for this new facility is the search for planets orbiting other stars. Australian astronomers, and the Anglo-Australian Telescope, have played a leading role in this new frontier for astronomy, detecting 25 of the 250-odd extrasolar planets known to orbit nearby stars. The CYCLOPS project brings together a team of leading Australian astronomers to build on this track record with a new facility that further advances Australia's capabilities in both this field, and several other high-profile astronomical endeavours: including the study of seismology in stellar interiors, the detailed measurement of elemental abundances in stars throughout our Galaxy, and the mapping of spot features on the surfaces of stars.Read moreRead less
Three-dimensional structure determination of biomolecular assemblies from sparse data of different length scales. New computer algorithms will be combined with sparse experimental structure restraints, obtained with novel protein chemistry technologies, to generate accurate three-dimensional (3D) models of proteins and protein assemblies in solution and in the solid state. The new strategies will greatly increase the number of protein targets amenable to rational drug design.
Design and verification of correct, efficient and secure concurrent systems. This project aims to provide methods for the design and verification of correct, secure and efficient concurrent software that are scalable and mechanised. Computers with multiple processors are now the norm and are used in a wide range of safety, security and mission critical software applications such as transport, health and infrastructure. These multi-core architectures have the potential to lead to important effici ....Design and verification of correct, efficient and secure concurrent systems. This project aims to provide methods for the design and verification of correct, secure and efficient concurrent software that are scalable and mechanised. Computers with multiple processors are now the norm and are used in a wide range of safety, security and mission critical software applications such as transport, health and infrastructure. These multi-core architectures have the potential to lead to important efficiency gains, but can introduce complex and error-prone behaviours that cannot be managed using traditional software development approaches. This project will produce better, scalable and mechanised methods for the design and verification of such software which is expected to reduce the prevalence of failures in efficient, modern software.Read moreRead less
Provable elimination of information leakage through timing channels. This project aims to develop techniques to solve the issue in information security of unauthorised information flow resulting from competition for shared hardware resources. The project will combine operating systems design, formal hardware models, information-flow reasoning and theorem proving to achieve a goal that is widely considered infeasible. The project is expected to result in a system that prevents leakage of critical ....Provable elimination of information leakage through timing channels. This project aims to develop techniques to solve the issue in information security of unauthorised information flow resulting from competition for shared hardware resources. The project will combine operating systems design, formal hardware models, information-flow reasoning and theorem proving to achieve a goal that is widely considered infeasible. The project is expected to result in a system that prevents leakage of critical information, such as encryption keys, through timing channels. This should prevent sophisticated attacks on public clouds, mobile devices and military-grade cross-domain devices.Read moreRead less