Efficient data mining methods for evidence-based decision making. This project aims to develop efficient data mining methods for causal predictions. Evidence-based decision making (EBD), such as evidence-based medicine and policy, is always preferable. To support EBD, causal predictions forecast how outcomes change when conditions are manipulated. Progress has been made in theoretical research on causal inference based on observational data, but few methods can automatically mine causal signals ....Efficient data mining methods for evidence-based decision making. This project aims to develop efficient data mining methods for causal predictions. Evidence-based decision making (EBD), such as evidence-based medicine and policy, is always preferable. To support EBD, causal predictions forecast how outcomes change when conditions are manipulated. Progress has been made in theoretical research on causal inference based on observational data, but few methods can automatically mine causal signals from the data and methods for efficient causal predictions based on data are even fewer. This project will apply its methods to biomedical problems. The outcomes could support smart and data-driven evidence based decision making in many areas, such as therapeutics and government policy making.Read moreRead less
The Impact Of The Neonatal Gut Microbiome On Specific And Nonspecific Vaccine Responses.
Funder
National Health and Medical Research Council
Funding Amount
$661,496.00
Summary
Humans are colonised by a large and diverse group of microorganisms, collectively known as the microbiome. The gut microbiome, in particular, hosts an enormous abundance and diversity of bacteria, which perform a range of essential beneficial functions. Our study will investigate whether disruption of the gut microbiome in newborns, for example through antibiotic usage or maternal diet, leads to an impairment of subsequent immune responses to childhood immunisations.
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
A data driven paradigm for service-oriented system engineering. This project aims to design and develop a data driven paradigm for service-oriented system engineering that allows system engineers and domain experts in different domains to build software systems easily in order to enable fast technology transfer within and across domain boundaries. This model integrates and automates a suite of efficient approaches for system structure determination, validation and recommendation based on keyword ....A data driven paradigm for service-oriented system engineering. This project aims to design and develop a data driven paradigm for service-oriented system engineering that allows system engineers and domain experts in different domains to build software systems easily in order to enable fast technology transfer within and across domain boundaries. This model integrates and automates a suite of efficient approaches for system structure determination, validation and recommendation based on keyword search, subgraph isomorphism and substructure query techniques. This project is expected to significantly accelerate the application of new technologies, for example, big data analytics and Internet of Things, in many of Australia's critical domains such as e-Health, smart cities, and cybersecurity.Read moreRead less
How IsomiRs Expand The MicroRNA Functional Repertoire In Affecting Gene Expression
Funder
National Health and Medical Research Council
Funding Amount
$439,570.00
Summary
MicroRNAs function as regulators of gene expression. It is becoming appreciated that microRNAs are frequently expressed as variants with subtly different sequences. We find here that variation in one important cancer-associated microRNA, miR-222, promotes differences in the behaviour of cells expressing them. This work seeks to understand how microRNA variation confers such properties to cells, to identify the genes miR-222 variants regulate, and to examine how widespread it is that microRNA var ....MicroRNAs function as regulators of gene expression. It is becoming appreciated that microRNAs are frequently expressed as variants with subtly different sequences. We find here that variation in one important cancer-associated microRNA, miR-222, promotes differences in the behaviour of cells expressing them. This work seeks to understand how microRNA variation confers such properties to cells, to identify the genes miR-222 variants regulate, and to examine how widespread it is that microRNA variation contributes to cancer.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH170100013
Funder
Australian Research Council
Funding Amount
$2,962,655.00
Summary
ARC Research Hub for Digital Enhanced Living. The ARC Research Hub for Digital Enhanced Living aims to address the growing challenges of aging people living in their own home or residential care. This will be through inventing new personalised medical technologies through an innovative approach, with a multi-disciplinary team leveraging diverse expertise. An enhanced capacity to create and deploy fit-for-purpose personalised health solutions will result in revenues from new and repurposed device ....ARC Research Hub for Digital Enhanced Living. The ARC Research Hub for Digital Enhanced Living aims to address the growing challenges of aging people living in their own home or residential care. This will be through inventing new personalised medical technologies through an innovative approach, with a multi-disciplinary team leveraging diverse expertise. An enhanced capacity to create and deploy fit-for-purpose personalised health solutions will result in revenues from new and repurposed devices, analytics and integration platforms. New jobs and improved care will see cost reductions, better use of resources and enhanced mental, physical and social well-being.Read moreRead less
Model-based error location in Java programs. The construction of modern software requires extensive testing and
debugging in addition to using appropriate specification, design, and
verification techniques. Testing and debugging are very time-consuming
and costly, drawing - according to recent articles - "typically 50%
or more of the resources for software projects''. By providing a new,
flexible approach to the debugging of complex software, this project
offers the potential of significant cost ....Model-based error location in Java programs. The construction of modern software requires extensive testing and
debugging in addition to using appropriate specification, design, and
verification techniques. Testing and debugging are very time-consuming
and costly, drawing - according to recent articles - "typically 50%
or more of the resources for software projects''. By providing a new,
flexible approach to the debugging of complex software, this project
offers the potential of significant cost savings, highly beneficial to
the ICT industry. Lessons learned from the demonstration prototype,
can be directly carried over into commercial tool development. In
addition, the project strengthens links to high quality European
research laboratories.Read moreRead less
Model-based error location in concurrent software. The construction of modern software requires extensive testing and debugging in addition to using appropriate specification, design, and verification techniques. Testing and debugging are very time-consuming and costly, drawing - according to recent articles - ``typically 50\% or more of the resources for software projects''. By extending the power of a new, flexible debugging approach, this project offers the potential of significant cost savin ....Model-based error location in concurrent software. The construction of modern software requires extensive testing and debugging in addition to using appropriate specification, design, and verification techniques. Testing and debugging are very time-consuming and costly, drawing - according to recent articles - ``typically 50\% or more of the resources for software projects''. By extending the power of a new, flexible debugging approach, this project offers the potential of significant cost savings, highly beneficial to any industry with a significant ICT component, e.g., defense. Lessons learned from the demonstration prototype, can be directly carried over into commercial tool development. The project strengthens links to high quality European research laboratories.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100153
Funder
Australian Research Council
Funding Amount
$361,446.00
Summary
Automatically summarising and measuring software development activity. This project aims to create technologies for automatically repackaging, interpreting, and aggregating software development activity. The project will devise new natural-language summarisation approaches and productivity metrics that use all data available in a software repository. This is likely to lead to knowledge and tools that allow organisations to quickly integrate new developers into existing software projects, to impr ....Automatically summarising and measuring software development activity. This project aims to create technologies for automatically repackaging, interpreting, and aggregating software development activity. The project will devise new natural-language summarisation approaches and productivity metrics that use all data available in a software repository. This is likely to lead to knowledge and tools that allow organisations to quickly integrate new developers into existing software projects, to improve project awareness, and to increase productivity goals. The outcomes would include a comprehensive decision and awareness support system for software projects, based on automating the creation and continual updating of developer activity summaries and measures.Read moreRead less
Three-dimensional magnetotelluric and controlled-source electromagnetic modelling and inversion in isotropic and anisotropic media with Gaussian Quadrature Grids. Electromagnetic methods are widely used by geophysicists in many applications, including mineral, petroleum and geothermal exploration, environmental and groundwater characterisation, and in imaging of Earth and other planets. Large data-sets are routinely collected, but to interpret these carefully we need efficient computer modellin ....Three-dimensional magnetotelluric and controlled-source electromagnetic modelling and inversion in isotropic and anisotropic media with Gaussian Quadrature Grids. Electromagnetic methods are widely used by geophysicists in many applications, including mineral, petroleum and geothermal exploration, environmental and groundwater characterisation, and in imaging of Earth and other planets. Large data-sets are routinely collected, but to interpret these carefully we need efficient computer modelling tools that incorporate the complexity of the subsurface. We will develop a new computer algorithm that uses an innovative approach to model the Earth in three dimensions. Computer codes will be available through the national AuScope infrastructure facilities, so that researchers will have free access to algorithms, largely for the first time, to better interpret their data.Read moreRead less