A Grid based platform for multi-scaled biological simulation. Heart disease currently affects over 3.5 million Australians. In 2006 it claimed the lives of almost 46,000 Australians (34% of all deaths). We will develop enabling technology that underpins cardiac disease research, offering potential for new treatments and pharmaceutical therapies. Even a small improvement in this area can translate into significant national benefit. Further, the mathematical techniques and software tools we will d ....A Grid based platform for multi-scaled biological simulation. Heart disease currently affects over 3.5 million Australians. In 2006 it claimed the lives of almost 46,000 Australians (34% of all deaths). We will develop enabling technology that underpins cardiac disease research, offering potential for new treatments and pharmaceutical therapies. Even a small improvement in this area can translate into significant national benefit. Further, the mathematical techniques and software tools we will develop, whilst focused on heart tissue, will have broader applicability, and may underpin advancements in other disciplines. Finally, we expect that the software solutions and infrastructure will have both commercial and strategic value in their own right.Read moreRead less
The systems biology of stem cells. Using new bioinformatic methods, this project aims to identify new classifiers of different stem cell populations, develop statistical models that address population heterogeneity and provide molecular predictors of the differentiation potential of stem cells. Understanding, predicting and directing the processes of differentiation are major goals in the disciplines of stem cell biology, developmental biology, tissue engineering and regenerative medicine. Molec ....The systems biology of stem cells. Using new bioinformatic methods, this project aims to identify new classifiers of different stem cell populations, develop statistical models that address population heterogeneity and provide molecular predictors of the differentiation potential of stem cells. Understanding, predicting and directing the processes of differentiation are major goals in the disciplines of stem cell biology, developmental biology, tissue engineering and regenerative medicine. Molecular atlas projects have successfully revealed rules of genome output and regulation, by mining patterns that are evident across multiple cell types and datasets. By applying this philosophy to relevant, well-curated stem cell experiments, this project aims to create new methods for the integration and interrogation of smaller individual datasets. These methods should have broad utility and enable new avenues in tissue engineering.Read moreRead less
Formal modelling and analysis of software requirements for air traffic management systems for improved integrity assurance. This project will significantly reduce the time and cost of developing software for critical applications such as aviation and air traffic management. As well as improving the trustworthiness of safety-critical computer-based systems, this project will also enable system improvements to be deployed faster and more reliably.
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water ....Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water and soil should lead to deeper understanding of the dynamics, variation and transfer of genetic material within these resources’ microbial communities, strategies to manage microbial diversity, and improved productivity and long-term sustainability for these resources.Read moreRead less
Understanding concurrent programs using rely-guarantee thinking. Multi-core processors are standard in computers and devices (e.g. smart phones) but much of the software available for these machines is either unreliable or does not exploit the available hardware parallelism. This project will devise techniques for designing concurrent software that exploits these platforms while delivering dependable operation.
An extensible framework for analysis of Java language-based security conformance. Java is a programming language and platform running on 3 billion devices. While Java provides a sandbox-based security architecture within the Java Class Library to protect systems from untrusted code downloaded from Internet, it cannot defend against implementation bugs that occur in the Java Class Library. The goal of this project is to provide a formal model of the Java security architecture, which can be used b ....An extensible framework for analysis of Java language-based security conformance. Java is a programming language and platform running on 3 billion devices. While Java provides a sandbox-based security architecture within the Java Class Library to protect systems from untrusted code downloaded from Internet, it cannot defend against implementation bugs that occur in the Java Class Library. The goal of this project is to provide a formal model of the Java security architecture, which can be used by program analysers to identify faulty or insufficient security checks in the Java Class Library that may lead to the sandbox being bypassed.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668447
Funder
Australian Research Council
Funding Amount
$320,000.00
Summary
Enterprise Grid Laboratory. Parallel and distributed processing can improve company profit, lower costs of design, production and deployment of new technologies, and create better business environments. To achieve this, new inexpensive parallel and distributed systems are needed. Research and initial developments show that such systems can be built based on enterprise grids. The understanding of enterprise grids, and in particular their operating systems, scheduling algorithms, load balancing, h ....Enterprise Grid Laboratory. Parallel and distributed processing can improve company profit, lower costs of design, production and deployment of new technologies, and create better business environments. To achieve this, new inexpensive parallel and distributed systems are needed. Research and initial developments show that such systems can be built based on enterprise grids. The understanding of enterprise grids, and in particular their operating systems, scheduling algorithms, load balancing, heterogeneity, transparency, applications deployment, is of the most critical importance for their development and taking them by industry and business. The new laboratory funded by this grant will place Australia at the forefront of research into the future generation of grids.Read moreRead less
Special Research Initiatives - Grant ID: SR0567393
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
Infrastructure for large-scale data resource sharing between research institutions – an environmental case study. The project creates a federated distributed data infrastructure for research, that encourages data creators to make their data available to other scientists, and encourages users to make use of data available from many sources. The vision is to establish an ICT infrastructure to facilitate a whole-of-environment approach to environmental research. The outcome is a proof-of-concept ....Infrastructure for large-scale data resource sharing between research institutions – an environmental case study. The project creates a federated distributed data infrastructure for research, that encourages data creators to make their data available to other scientists, and encourages users to make use of data available from many sources. The vision is to establish an ICT infrastructure to facilitate a whole-of-environment approach to environmental research. The outcome is a proof-of-concept application based upon a case study of Queensland Environmental Protection Agency’s databases, to gain an in-depth understanding of the complexity, scope and key technological barriers for establishing an ICT infrastructure, to identify where the latest technologies can be used and where the gaps are for these technologies to be used in environmental sciences.Read moreRead less
Novel antimicrobial target discovery by an integrated approach. The project aims to uncover the molecular targets of BDM-I, a novel antimicrobial candidate discovered by the start-up Australian company BioDiem Ltd. BDM-I is active against many drug resistant bacterial and fungal microorganisms and it is currently in pre-clinical development. However, the lack of resistant phenotypes makes it difficult to identify BDM-I’s mechanism of action. The project plans to use an integrated approach that c ....Novel antimicrobial target discovery by an integrated approach. The project aims to uncover the molecular targets of BDM-I, a novel antimicrobial candidate discovered by the start-up Australian company BioDiem Ltd. BDM-I is active against many drug resistant bacterial and fungal microorganisms and it is currently in pre-clinical development. However, the lack of resistant phenotypes makes it difficult to identify BDM-I’s mechanism of action. The project plans to use an integrated approach that combines a novel technique of in silico screening with experimental validation. Project outcomes are anticipated to include the first computational method to integrate target and ligand similarity for proteome-scale target and off-target discovery, which will advance the global fight against drug-resistant microorganisms.Read moreRead less