Smart Information Use for PET-CT Quantitative Molecular Imaging. This project aims to use advanced computing algorithms to tackle
challenging problems associated with a new medical technology called
PET-CT which combines two imaging modalities in one device. While this technology is very new and has great potential in cancer and brain disorders, it also poses major challenges for information processing and transmission. We will address these challenges by developing advanced algorithms that op ....Smart Information Use for PET-CT Quantitative Molecular Imaging. This project aims to use advanced computing algorithms to tackle
challenging problems associated with a new medical technology called
PET-CT which combines two imaging modalities in one device. While this technology is very new and has great potential in cancer and brain disorders, it also poses major challenges for information processing and transmission. We will address these challenges by developing advanced algorithms that optimally extract information from PET and CT using mathematical models that correct for the various sources of inaccuracy. Our research will put Australian biomedical researchers and healthcare professionals at the forefront of advanced medical imaging technology.Read moreRead less
An Innovative Multimedia Framework for Multidimensional PET-CT Image Navigation and Communication. The recent development of a combined positron emission tomography and computerized tomography (PET-CT) device ushers in a completely new era in molecular imaging that will revolutionize the approach to imaging in the clinical environment. In this project, we address a number of the critical challenges associated with the introduction of PET-CT, and provide a range of innovative multimedia technolo ....An Innovative Multimedia Framework for Multidimensional PET-CT Image Navigation and Communication. The recent development of a combined positron emission tomography and computerized tomography (PET-CT) device ushers in a completely new era in molecular imaging that will revolutionize the approach to imaging in the clinical environment. In this project, we address a number of the critical challenges associated with the introduction of PET-CT, and provide a range of innovative multimedia technologies to visualize, manipulate and deliver these multi-dimensional data. Our research will greatly enhance the clinical and research benefits of PET-CT and facilitate new discoveries which will have a significant scientific and social impact in Australia and the world at large.Read moreRead less
Novel EEG data mining methods for detecting and monitoring brain injury. The outcomes of this project could ultimately help produce novel technology which would enable bedside monitoring of brain function in patients with brain injuries such as stroke. This technology could aid critical care and treatment of such patients. Hence patients' recoveries could be positively affected and the high death or disability rates associated with such conditions could be reduced. A host of economic and social ....Novel EEG data mining methods for detecting and monitoring brain injury. The outcomes of this project could ultimately help produce novel technology which would enable bedside monitoring of brain function in patients with brain injuries such as stroke. This technology could aid critical care and treatment of such patients. Hence patients' recoveries could be positively affected and the high death or disability rates associated with such conditions could be reduced. A host of economic and social benefits for patients, their families, hospitals and their staff, governments and healthcare organisations could thus result. The developed technology would be non-invasive, compact and relatively inexpensive, and could thus be used in rural and regional hospitals, thereby also benefiting patients in those communities. Read moreRead less
A new generation of multi-modality biomedical image visualisations. This research will overcome the urgent and significant burden in the routine clinical visualisation of multiple-modality biomedical image data, which are complex and exquisitely detailed from the new generation of high-resolution medical imaging scanners. Together with our industry partner RPA Hospital, we will produce 3D visualisation methodologies that will simplify and revolutionise the way biomedical data are visualised, ana ....A new generation of multi-modality biomedical image visualisations. This research will overcome the urgent and significant burden in the routine clinical visualisation of multiple-modality biomedical image data, which are complex and exquisitely detailed from the new generation of high-resolution medical imaging scanners. Together with our industry partner RPA Hospital, we will produce 3D visualisation methodologies that will simplify and revolutionise the way biomedical data are visualised, analysed and interpreted by imaging specialists and disseminated to doctors and patients. Given the pivotal role that imaging plays in modern healthcare, this will improve diagnosis and assessment, and enhance Australia's leading position in the development of frontier technologies.Read moreRead less
Large scale knowledge and image based biomedical modelling and derivation of PET-CT disease maps and treatment response. The smart use of information to improve, promote and maintain good healthcare is a critical mission for our country. Cancer is a serious problem in Australian society and 1 in 4 individuals will be affected by it in their lifetime. Our research is focussed on two types of cancer - lung cancer and the lymphomas - and it will use IT in a novel way to extract important informatio ....Large scale knowledge and image based biomedical modelling and derivation of PET-CT disease maps and treatment response. The smart use of information to improve, promote and maintain good healthcare is a critical mission for our country. Cancer is a serious problem in Australian society and 1 in 4 individuals will be affected by it in their lifetime. Our research is focussed on two types of cancer - lung cancer and the lymphomas - and it will use IT in a novel way to extract important information from a very large biomedical data repository. We hope that it will improve personalised diagnosis and treatment in these cancers and provide new information on how some cancers spread and resist our usual treatments. We think our techniques will contribute to other research areas such as astronomy, agriculture, water/energy resources, and security.Read moreRead less
Information Technology Aided Diagnosis of Dementia with PET-CT Imaging. Dementia is a significant health problem and approximately 162,000 Australians currently suffer from this disease, with costs estimated at $6 billion annually in Australia and a profound effect on the lives of carers and family members. With the ageing of the Australian population, the patient number is expected to rise to 500,000 by 2040.This research will apply innovative IT approaches to develop computer assisted diagnosi ....Information Technology Aided Diagnosis of Dementia with PET-CT Imaging. Dementia is a significant health problem and approximately 162,000 Australians currently suffer from this disease, with costs estimated at $6 billion annually in Australia and a profound effect on the lives of carers and family members. With the ageing of the Australian population, the patient number is expected to rise to 500,000 by 2040.This research will apply innovative IT approaches to develop computer assisted diagnosis of early dementia, when treatment is possible, from combined functional and anatomical imaging modalities (PET-CT). This will not only add considerable value to Australia's medical imaging infrastructure and smart use of information, but will ultimately also deliver substantial benefits to our nation and community.Read moreRead less
Microchip Impedance Biosensor for Biomedical Diagnostics. This research proposal uses an innovative engineering approach based on novel nanomaterials with the aim of developing a new and generic biosensing technology with the potential to be widely applied in many areas including medical diagnostics, environmental control, industry and biosecurity. The outcomes from this project will benefit Australia by contributing through the development of novel materials, new technologies and new devices. ....Microchip Impedance Biosensor for Biomedical Diagnostics. This research proposal uses an innovative engineering approach based on novel nanomaterials with the aim of developing a new and generic biosensing technology with the potential to be widely applied in many areas including medical diagnostics, environmental control, industry and biosecurity. The outcomes from this project will benefit Australia by contributing through the development of novel materials, new technologies and new devices. The development of technological innovations based on fabricated nanomaterials, will also enhance capacity in frontier technology such as nanotechnology, and build Australia’s strength in using new biosensing technologies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100108
Funder
Australian Research Council
Funding Amount
$175,000.00
Summary
Ultra-high frequency non-contact vibrometry equipment for biomicrofluidics metrology. This equipment will enable experimental vibration measurement up to an unprecedented one billion cycles per second of motion smaller than the width of a helium atom (20 femtometres). Understanding and harnessing the phenomena unique to this regime, especially very large accelerations surpassing one billion times the acceleration of gravity, will enable the development of rapid protein crystallisation techniques ....Ultra-high frequency non-contact vibrometry equipment for biomicrofluidics metrology. This equipment will enable experimental vibration measurement up to an unprecedented one billion cycles per second of motion smaller than the width of a helium atom (20 femtometres). Understanding and harnessing the phenomena unique to this regime, especially very large accelerations surpassing one billion times the acceleration of gravity, will enable the development of rapid protein crystallisation techniques and constant-temperature organic chemical reaction enhancement for rapid development of new drugs, new devices for measuring the profile of surfaces at video speeds (videoAFM), new micro- and nano-devices for fluid pumping, mixing, colloidal separation and concentration, and new autonomous nanorobots for non-invasive microsurgery.Read moreRead less
Isolation and analysis of novel caspases. Apoptosis is an evolutionarily conserved cellular process which must be tightly controlled for normal development and to avoid disease. Rapid progress has been made recently in the elucidation of apoptotic pathways, but many important components are likely still unknown. The caspases constitute the effector arm of apoptotic signalling pathways and some members play important roles in cytokine maturation. We aim to identify novel caspases using an innovat ....Isolation and analysis of novel caspases. Apoptosis is an evolutionarily conserved cellular process which must be tightly controlled for normal development and to avoid disease. Rapid progress has been made recently in the elucidation of apoptotic pathways, but many important components are likely still unknown. The caspases constitute the effector arm of apoptotic signalling pathways and some members play important roles in cytokine maturation. We aim to identify novel caspases using an innovative technique, and to characterise their function and regulation. Molecules identified in this project may be candidate targets for therapies which modulate apoptosis for treatment or prevention of disease, or diagnostic reagent development.Read moreRead less
Discovery of Novel Respiratory Viruses Causing Influenza-Like Illness in Healthy Australian Adults Aged 18 to 64 Years. This work will inform our understanding of the causes of acute respiratory illnesses in Australia at the present time by looking for both known and previously undiscovered respiratory viruses. Increasing the knowledge base regarding causes of disease will have downstream relevance for health policy planners seeking to assess the burden of disease due to different causes. Early ....Discovery of Novel Respiratory Viruses Causing Influenza-Like Illness in Healthy Australian Adults Aged 18 to 64 Years. This work will inform our understanding of the causes of acute respiratory illnesses in Australia at the present time by looking for both known and previously undiscovered respiratory viruses. Increasing the knowledge base regarding causes of disease will have downstream relevance for health policy planners seeking to assess the burden of disease due to different causes. Early identification and description of new diseases will allow pre-emptive evaluation of new public health threats. This information will help to ensure availability and marketability of vaccines to prevent infection.Read moreRead less