Proteases are enzymes that degrade other proteins. These molecules are essential for life and drive fundamental processes such as blood clotting and the inflammatory response. Protease dysfunction underlies numerous human diseases, including cancer. This proposal aims to investigate whether structural information can be used to improve our ability to accurately predict the target specificity of proteases.
My research team is focused on human parasites of major relevance to the Australian water industry and/or global public health. Our primary focus is the use of advanced technologies to improve understanding of these parasites and to utilize this information to underpin development of new drugs to treat them and novel diagnostic tests to improve their control.
Smart Information Use for PET-CT Quantitative Molecular Imaging. This project aims to use advanced computing algorithms to tackle
challenging problems associated with a new medical technology called
PET-CT which combines two imaging modalities in one device. While this technology is very new and has great potential in cancer and brain disorders, it also poses major challenges for information processing and transmission. We will address these challenges by developing advanced algorithms that op ....Smart Information Use for PET-CT Quantitative Molecular Imaging. This project aims to use advanced computing algorithms to tackle
challenging problems associated with a new medical technology called
PET-CT which combines two imaging modalities in one device. While this technology is very new and has great potential in cancer and brain disorders, it also poses major challenges for information processing and transmission. We will address these challenges by developing advanced algorithms that optimally extract information from PET and CT using mathematical models that correct for the various sources of inaccuracy. Our research will put Australian biomedical researchers and healthcare professionals at the forefront of advanced medical imaging technology.Read moreRead less
An Innovative Multimedia Framework for Multidimensional PET-CT Image Navigation and Communication. The recent development of a combined positron emission tomography and computerized tomography (PET-CT) device ushers in a completely new era in molecular imaging that will revolutionize the approach to imaging in the clinical environment. In this project, we address a number of the critical challenges associated with the introduction of PET-CT, and provide a range of innovative multimedia technolo ....An Innovative Multimedia Framework for Multidimensional PET-CT Image Navigation and Communication. The recent development of a combined positron emission tomography and computerized tomography (PET-CT) device ushers in a completely new era in molecular imaging that will revolutionize the approach to imaging in the clinical environment. In this project, we address a number of the critical challenges associated with the introduction of PET-CT, and provide a range of innovative multimedia technologies to visualize, manipulate and deliver these multi-dimensional data. Our research will greatly enhance the clinical and research benefits of PET-CT and facilitate new discoveries which will have a significant scientific and social impact in Australia and the world at large.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101106
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Economic rise and decline - as seen from space. This research evaluates the accuracy of night-light based measures of local economic change. Satellite images of night-light cover the entire inhabited regions of the world, thus establishing whether these data can be used to supplement traditional measures of economic activity in countries with weak statistical systems would be a global public good.
Novel EEG data mining methods for detecting and monitoring brain injury. The outcomes of this project could ultimately help produce novel technology which would enable bedside monitoring of brain function in patients with brain injuries such as stroke. This technology could aid critical care and treatment of such patients. Hence patients' recoveries could be positively affected and the high death or disability rates associated with such conditions could be reduced. A host of economic and social ....Novel EEG data mining methods for detecting and monitoring brain injury. The outcomes of this project could ultimately help produce novel technology which would enable bedside monitoring of brain function in patients with brain injuries such as stroke. This technology could aid critical care and treatment of such patients. Hence patients' recoveries could be positively affected and the high death or disability rates associated with such conditions could be reduced. A host of economic and social benefits for patients, their families, hospitals and their staff, governments and healthcare organisations could thus result. The developed technology would be non-invasive, compact and relatively inexpensive, and could thus be used in rural and regional hospitals, thereby also benefiting patients in those communities. Read moreRead less
Modelling Income Distributions over Space and Time: 1985-2010. The aim of this project is to develop and use interpolation and extrapolation methods, designed to overcome data scarcity, to estimate annual income distributions for countries, regions and the world for the period 1985 to 2010, facilitating measurement and comparison of changes in inequality, per capita income, poverty, and pro-poor growth, at national, regional and global levels. Reliable estimates of these welfare measures provide ....Modelling Income Distributions over Space and Time: 1985-2010. The aim of this project is to develop and use interpolation and extrapolation methods, designed to overcome data scarcity, to estimate annual income distributions for countries, regions and the world for the period 1985 to 2010, facilitating measurement and comparison of changes in inequality, per capita income, poverty, and pro-poor growth, at national, regional and global levels. Reliable estimates of these welfare measures provide valuable information for policy advisors and other researchers interested in growth and welfare of society.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102503
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Circulating tumor cell isolation and detection: an integrated microfluidic capture device based on alternating current (AC) electrohydrodynamics. The detection of circulating tumor cells in clinical samples plays a critical role in cancer diagnosis and management. This project aims to develop microfluidic technology by incorporating AC electric field-induced vortices with three-dimensional microstructured electrodes that will advance our ability to analyse rare cells and proteins in clinical sam ....Circulating tumor cell isolation and detection: an integrated microfluidic capture device based on alternating current (AC) electrohydrodynamics. The detection of circulating tumor cells in clinical samples plays a critical role in cancer diagnosis and management. This project aims to develop microfluidic technology by incorporating AC electric field-induced vortices with three-dimensional microstructured electrodes that will advance our ability to analyse rare cells and proteins in clinical samples.Read moreRead less
Tuneable “Nano-Shearing”: An Innovative Mechanism for the Accurate and Specific Capture of Cells and Molecules. Recent investigations have discovered a tuneable electro-hydrodynamic force which drives lateral fluid motion within a few nanometers of an electrode surface. Because the magnitude of this fluid shear force can be tuned externally (for example, via the application of an AC electric field), it provides a new capability to physically displace weakly (non-specifically) bound cellular and ....Tuneable “Nano-Shearing”: An Innovative Mechanism for the Accurate and Specific Capture of Cells and Molecules. Recent investigations have discovered a tuneable electro-hydrodynamic force which drives lateral fluid motion within a few nanometers of an electrode surface. Because the magnitude of this fluid shear force can be tuned externally (for example, via the application of an AC electric field), it provides a new capability to physically displace weakly (non-specifically) bound cellular and molecular analytes. By performing research to further understand and develop this tuneable effect, this project aims to build and test a new platform technology to enable highly efficient capture and specific detection of low concentration pathogenic molecules and circulating tumour cells (CTCs).Read moreRead less