Data-led bioengineering to uncover hidden chemical wealth in bacteria. The soil bacteria Nocardia are an untapped source of industrially prized chemical compounds called natural products. This project aims to develop innovative bioprospecting genomics technologies built from the disciplines of microbiology, biochemistry and computational statistics to discover hundreds of new natural products in Nocardia. This project will unlock the diversity of potent new enzymes and molecules with high econom ....Data-led bioengineering to uncover hidden chemical wealth in bacteria. The soil bacteria Nocardia are an untapped source of industrially prized chemical compounds called natural products. This project aims to develop innovative bioprospecting genomics technologies built from the disciplines of microbiology, biochemistry and computational statistics to discover hundreds of new natural products in Nocardia. This project will unlock the diversity of potent new enzymes and molecules with high economic value that could include insecticides to protect crops, bioactives to fight diseases, or new enzymes for food and biofuel production. This research unlocks enormous hidden chemical potential in soil bacteria, to build sustainable national economic growth through innovative, high-value industrial chemical development.Read moreRead less
Modelling Income Distributions over Space and Time: 1985-2010. The aim of this project is to develop and use interpolation and extrapolation methods, designed to overcome data scarcity, to estimate annual income distributions for countries, regions and the world for the period 1985 to 2010, facilitating measurement and comparison of changes in inequality, per capita income, poverty, and pro-poor growth, at national, regional and global levels. Reliable estimates of these welfare measures provide ....Modelling Income Distributions over Space and Time: 1985-2010. The aim of this project is to develop and use interpolation and extrapolation methods, designed to overcome data scarcity, to estimate annual income distributions for countries, regions and the world for the period 1985 to 2010, facilitating measurement and comparison of changes in inequality, per capita income, poverty, and pro-poor growth, at national, regional and global levels. Reliable estimates of these welfare measures provide valuable information for policy advisors and other researchers interested in growth and welfare of society.Read moreRead less
Modelling Food Expenditure, Analysing Nutrient Security, Measuring Hunger and Calculating Purchasing Power Parity: Methodological Advances with Policy Applications. The analysis of consumption changes in selected Asian countries will throw light on Australia's trade potential, especially with one of the fastest growing countries.
More informed debate on the role of trade and aid in reducing hunger and poverty.Following the 2000 Millenium summit and the step up of Australian developmental aid, ....Modelling Food Expenditure, Analysing Nutrient Security, Measuring Hunger and Calculating Purchasing Power Parity: Methodological Advances with Policy Applications. The analysis of consumption changes in selected Asian countries will throw light on Australia's trade potential, especially with one of the fastest growing countries.
More informed debate on the role of trade and aid in reducing hunger and poverty.Following the 2000 Millenium summit and the step up of Australian developmental aid, the subject has returned to the centre stage in policy discussions.
The systematic use of unit value information available elsewhere, but currently lacking in ABS data, will help the latter in improving its HES.
Contribute to "understanding our region and the world"(Key Priority Goal in Research Priority 4 of ARC).
Provide data sets for use in Australian RHD dissertations .
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An econometric analysis of the impact of education on health in developing countries. This project will provide empirical knowledge on whether education affects health over the life course in developing countries. This research will aid the design of more cost effective strategies aiming to reduce poverty and promote economic development, which will ultimately lead to a more prosperous and safe region and world.
Econometric estimation and analysis of country, regional and global income distributions. The project will provide valuable information on characteristics of the income distribution for Australia, and the distributions for countries of socio-economic significance to Australia. The findings will enable Australian government and non-government organisations and international agencies to assess the effects of various policies such as those designed to reduce world poverty. The project can help Aust ....Econometric estimation and analysis of country, regional and global income distributions. The project will provide valuable information on characteristics of the income distribution for Australia, and the distributions for countries of socio-economic significance to Australia. The findings will enable Australian government and non-government organisations and international agencies to assess the effects of various policies such as those designed to reduce world poverty. The project can help Australia understand the most immediate needs of countries in the region, information that is useful for formulating Australian policy responses that can alleviate poverty and lead to improved living standards in the region, thereby creating a harmonious and safer environment within the Asia-Pacific region.Read moreRead less
Nanoelectromechanical Mass Spectrometry with Molecular Imaging. This project aims to develop new technology to enable simultaneous measurement of the mass and conformation of single molecules. Mass spectrometry and high-resolution microscopy are independent analytical tools used widely to characterise the chemical and physical properties of molecules. This project aims to develop new technology based on advanced nanoelectromechanical systems that combines the capabilities of these complementary ....Nanoelectromechanical Mass Spectrometry with Molecular Imaging. This project aims to develop new technology to enable simultaneous measurement of the mass and conformation of single molecules. Mass spectrometry and high-resolution microscopy are independent analytical tools used widely to characterise the chemical and physical properties of molecules. This project aims to develop new technology based on advanced nanoelectromechanical systems that combines the capabilities of these complementary instruments. This would enable synchronous measurement of molecular mass and conformation with nanometre resolution. In contrast to current mass spectrometry, this technology could be operated in fluid and detect neutral species. This significant change in capability could be applied to advance biological and medical research.Read moreRead less
Isolation and analysis of novel caspases. Apoptosis is an evolutionarily conserved cellular process which must be tightly controlled for normal development and to avoid disease. Rapid progress has been made recently in the elucidation of apoptotic pathways, but many important components are likely still unknown. The caspases constitute the effector arm of apoptotic signalling pathways and some members play important roles in cytokine maturation. We aim to identify novel caspases using an innovat ....Isolation and analysis of novel caspases. Apoptosis is an evolutionarily conserved cellular process which must be tightly controlled for normal development and to avoid disease. Rapid progress has been made recently in the elucidation of apoptotic pathways, but many important components are likely still unknown. The caspases constitute the effector arm of apoptotic signalling pathways and some members play important roles in cytokine maturation. We aim to identify novel caspases using an innovative technique, and to characterise their function and regulation. Molecules identified in this project may be candidate targets for therapies which modulate apoptosis for treatment or prevention of disease, or diagnostic reagent development.Read moreRead less
Enhancing Selectivity and Detection in Miniaturised Analytical Separation Systems. Miniaturisation-compatible stationary phases and detection techniques will be developed for microseparation techniques of capillary electrochromatography and chip-based separation systems, and their analytical applications will be investigated. Replaceable stationary phases (RSP) of chromatographic particles suspended in reversible gels will be created by delivering a liquid RSP to the column followed by in situ ....Enhancing Selectivity and Detection in Miniaturised Analytical Separation Systems. Miniaturisation-compatible stationary phases and detection techniques will be developed for microseparation techniques of capillary electrochromatography and chip-based separation systems, and their analytical applications will be investigated. Replaceable stationary phases (RSP) of chromatographic particles suspended in reversible gels will be created by delivering a liquid RSP to the column followed by in situ immobilisation. This approach offers flexibility in optimising a number of parameters of the column and of its use for sample pre-treatment and preconcentration. Pulsed potentiometric detection will be developed for the abovementioned microseparation techniques, combining the advantages of pulsed amperometric techniques with the more universally responding potentiometric detection.Read moreRead less
Supply-side dynamics in the private rental housing market. Demographic and socio-economic trends, along with changes in housing policy, have resulted in increased reliance on the private rental sector. This has led to growing concerns about its capacity to respond. Our understanding of the supply dynamics of this tenure, and particularly that of low rent housing, is underdeveloped. This gap in our knowledge is due to lack of data and to methodological difficulties. Recent advances in econometric ....Supply-side dynamics in the private rental housing market. Demographic and socio-economic trends, along with changes in housing policy, have resulted in increased reliance on the private rental sector. This has led to growing concerns about its capacity to respond. Our understanding of the supply dynamics of this tenure, and particularly that of low rent housing, is underdeveloped. This gap in our knowledge is due to lack of data and to methodological difficulties. Recent advances in econometric techniques, in conjunction with the assembly of a unique data set, will be used to examine previously untested explanations, including microlevel filtering, behavioural,hazard function and spatial analyses.Read moreRead less
Photodissociation mass spectrometry for lipidome analysis. This project aims to develop and apply novel bioanalytical mass spectrometry-based methods and workflows to illuminate the otherwise hidden structural diversity and molecular complexity of the lipidome. The structure of individual lipids define their specific biological functions. A major requirement of analytical methods employed for lipid analysis on a lipidome-wide scale, therefore, is to enable the detailed structural characterisatio ....Photodissociation mass spectrometry for lipidome analysis. This project aims to develop and apply novel bioanalytical mass spectrometry-based methods and workflows to illuminate the otherwise hidden structural diversity and molecular complexity of the lipidome. The structure of individual lipids define their specific biological functions. A major requirement of analytical methods employed for lipid analysis on a lipidome-wide scale, therefore, is to enable the detailed structural characterisation of the, potentially, tens of thousands of individual molecular lipid species that may be present within a sample of interest. This project will develop and optimise novel, ultraviolet photodissociation-tandem mass spectrometry methods which will be integrated within an automated lipidome analysis workflow, to enable comprehensive global lipidome profiling and to reveal the structural diversity of lipids involved in fundamental cellular signalling processes.Read moreRead less