Development of a diagnostic microarray to detect aneuploidy in single cells. Chromosomal abnormalities account for about 10 per cent of all babies born with a defect. The risk of chromosomal abnormalities increases with maternal age and in patients with fertility problems. It has been estimated that 50 per cent of all embryos are aneuploid. Chromosomal aberrations also occur in the vast majority of tumours in humans. Accurate and rapid detection of chromosomal defects is an important health ser ....Development of a diagnostic microarray to detect aneuploidy in single cells. Chromosomal abnormalities account for about 10 per cent of all babies born with a defect. The risk of chromosomal abnormalities increases with maternal age and in patients with fertility problems. It has been estimated that 50 per cent of all embryos are aneuploid. Chromosomal aberrations also occur in the vast majority of tumours in humans. Accurate and rapid detection of chromosomal defects is an important health service delivered to the Australian public. This project aims to develop better tests for application in prenatal diagnostics including non-invasive testing of fetal cells from maternal circulation or cervical samples at 6-13 weeks gestation, IVF and cancer diagnostics.Read moreRead less
Microchip Impedance Biosensor for Biomedical Diagnostics. This research proposal uses an innovative engineering approach based on novel nanomaterials with the aim of developing a new and generic biosensing technology with the potential to be widely applied in many areas including medical diagnostics, environmental control, industry and biosecurity. The outcomes from this project will benefit Australia by contributing through the development of novel materials, new technologies and new devices. ....Microchip Impedance Biosensor for Biomedical Diagnostics. This research proposal uses an innovative engineering approach based on novel nanomaterials with the aim of developing a new and generic biosensing technology with the potential to be widely applied in many areas including medical diagnostics, environmental control, industry and biosecurity. The outcomes from this project will benefit Australia by contributing through the development of novel materials, new technologies and new devices. The development of technological innovations based on fabricated nanomaterials, will also enhance capacity in frontier technology such as nanotechnology, and build Australia’s strength in using new biosensing technologies.Read moreRead less
Childhood obesity, physical activity and wellbeing: Discovering the influence of children's understandings and experiences of places, spaces and communities. The study aims to discover 3-13 yr old children's understandings, perceptions & experiences of physical activity & associated places & spaces. Childhood obesity is a modern 'epidemic' & governments agree that low physical activity levels contribute significantly. Epidemiological & clinical research has been undertaken, but we lack Australia ....Childhood obesity, physical activity and wellbeing: Discovering the influence of children's understandings and experiences of places, spaces and communities. The study aims to discover 3-13 yr old children's understandings, perceptions & experiences of physical activity & associated places & spaces. Childhood obesity is a modern 'epidemic' & governments agree that low physical activity levels contribute significantly. Epidemiological & clinical research has been undertaken, but we lack Australian studies that systematically listen to & understand the pivotal voices of children themselves. Failure to develop such theoretically sound, practice-based understandings may mean ineffective interventions that misunderstand children's worlds. This collaborative study unites highly experienced researchers, practitioners & policy makers who will actively involve children in creating & using new knowledge.Read moreRead less
A model to investigate the relationships between social capital, social inclusion and industrial development. This study will develop a new model for investigating the relationships between social capital, social inclusion and industry development in a designated area under the Commonwealth Government Initiative in Regional Australia. The project will address whether high levels of social capital reduce social exclusion and the likely impacts of the ?dark side? of social capital upon communiti ....A model to investigate the relationships between social capital, social inclusion and industrial development. This study will develop a new model for investigating the relationships between social capital, social inclusion and industry development in a designated area under the Commonwealth Government Initiative in Regional Australia. The project will address whether high levels of social capital reduce social exclusion and the likely impacts of the ?dark side? of social capital upon communities. The study will draw on relevant contemporary theory, survey analysis, interviews and discussion forums to develop new explanations that will help build community capacities and inform the development of social policy, employment and industrial development.Read moreRead less
The effects of child disability on carer's labour market outcomes in Australia. Increasing prevalence of children with disabilities in Australia accompanied by lack of research makes this study imperative. The innovative approach adopted in this project means there will be a number of national benefits resulting from this study.
- It will help governments in Australia make more informed policies toward providing assistance to affected families, which will reduce the burden on families caring ....The effects of child disability on carer's labour market outcomes in Australia. Increasing prevalence of children with disabilities in Australia accompanied by lack of research makes this study imperative. The innovative approach adopted in this project means there will be a number of national benefits resulting from this study.
- It will help governments in Australia make more informed policies toward providing assistance to affected families, which will reduce the burden on families caring for children with disabilities.
- More informed policy will improve the well-being of such children.
- It will advance knowledge in the fields of labour and health economics, and econometrics, and hence enhance Australian research reputation in the fields.Read moreRead less
Supply-side dynamics in the private rental housing market. Demographic and socio-economic trends, along with changes in housing policy, have resulted in increased reliance on the private rental sector. This has led to growing concerns about its capacity to respond. Our understanding of the supply dynamics of this tenure, and particularly that of low rent housing, is underdeveloped. This gap in our knowledge is due to lack of data and to methodological difficulties. Recent advances in econometric ....Supply-side dynamics in the private rental housing market. Demographic and socio-economic trends, along with changes in housing policy, have resulted in increased reliance on the private rental sector. This has led to growing concerns about its capacity to respond. Our understanding of the supply dynamics of this tenure, and particularly that of low rent housing, is underdeveloped. This gap in our knowledge is due to lack of data and to methodological difficulties. Recent advances in econometric techniques, in conjunction with the assembly of a unique data set, will be used to examine previously untested explanations, including microlevel filtering, behavioural,hazard function and spatial analyses.Read moreRead less
Are the kids alright? Understanding the wellbeing of Australian children in their middle years. This project will produce the first comprehensive national stock-take of wellbeing among Australian children in their middle years, with a special focus on children who experience disadvantage. Findings will reflect children's views and experiences, have direct policy relevance and lay the groundwork for comparing and monitoring of child wellbeing.
Special Research Initiatives - Grant ID: SR0354583
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Biodevice fabrication through intelligent surface modification. Achieving the reliable control of the attachment of proteins and other macromolecules to surfaces needed for sophisticated biosensors and medical diagnostics requires expertise and infrastructure from a diverse range of disciplines from the physical, chemical and biological sciences and engineering. This network will bring together researchers from a multidisciplinary pool working on problems relevant to the creation of functional s ....Biodevice fabrication through intelligent surface modification. Achieving the reliable control of the attachment of proteins and other macromolecules to surfaces needed for sophisticated biosensors and medical diagnostics requires expertise and infrastructure from a diverse range of disciplines from the physical, chemical and biological sciences and engineering. This network will bring together researchers from a multidisciplinary pool working on problems relevant to the creation of functional surfaces for applications in biodevices. The program we envisage will break down the barriers imposed by disciplinary boundaries and technical terminology to bring together the skills and infrastructure required to make rapid advances in this field.Read moreRead less
A gold-coated magnetic nanoparticle biosensor for detecting microRNA. The project aims to develop a biosensor for detecting short sequences of RNA, called microRNA (miRNA) in blood. There are about 100 miRNA sequences that are involved in most biological processes. Changes in the levels of some miRNA sequences can serve as a biomarker for many diseases including cancers. The miRNA will be detected using gold-coated magnetic nanoparticles modified with DNA sequences complementary to the miRNA of ....A gold-coated magnetic nanoparticle biosensor for detecting microRNA. The project aims to develop a biosensor for detecting short sequences of RNA, called microRNA (miRNA) in blood. There are about 100 miRNA sequences that are involved in most biological processes. Changes in the levels of some miRNA sequences can serve as a biomarker for many diseases including cancers. The miRNA will be detected using gold-coated magnetic nanoparticles modified with DNA sequences complementary to the miRNA of interest to capture the miRNA. Application of a magnetic field allows the levels of miRNA to be detected electrochemically. The expected outcome is a commercialisable biosensor for miRNA both as a diagnostic early detection device and a prognostic device for a range of miRNA biomarkers.Read moreRead less
Electrochemical biosensors for detection of cardiac disease markers in blood. Cardiovascular diseases leading to heart failure have a prevalence of over 16 per cent in Australia. The social, economic and health burden is higher than for any other disease group. Hence, it is critically important to develop fit-for-purpose sensors of known cardiac biomarkers, which alert patients and clinicians of the risk of imminent heart failure.