Discovery Early Career Researcher Award - Grant ID: DE230100178
Funder
Australian Research Council
Funding Amount
$453,913.00
Summary
Fast, lightweight and live nanopore sequencing analysis. This project aims to address limitations in nanopore sequencing (latest emerging technology in genomics) by applying advanced computational methods. This project expects to create new knowledge in bioinformatics and computer science through innovative approaches that leverage the live data streaming capability of nanopore devices to deliver results rapidly, or in real-time. Expected outcomes include improved, highly efficient analysis meth ....Fast, lightweight and live nanopore sequencing analysis. This project aims to address limitations in nanopore sequencing (latest emerging technology in genomics) by applying advanced computational methods. This project expects to create new knowledge in bioinformatics and computer science through innovative approaches that leverage the live data streaming capability of nanopore devices to deliver results rapidly, or in real-time. Expected outcomes include improved, highly efficient analysis methods and designs for future creation of custom computer hardware for nanopore analysis. This will facilitate widespread adoption of nanopore technology in bioscience research and applied domains (health, agriculture, ecology, biosecurity and forensics), including for portable in-the-field applications. Read moreRead less
Smart Information Use for PET-CT Quantitative Molecular Imaging. This project aims to use advanced computing algorithms to tackle
challenging problems associated with a new medical technology called
PET-CT which combines two imaging modalities in one device. While this technology is very new and has great potential in cancer and brain disorders, it also poses major challenges for information processing and transmission. We will address these challenges by developing advanced algorithms that op ....Smart Information Use for PET-CT Quantitative Molecular Imaging. This project aims to use advanced computing algorithms to tackle
challenging problems associated with a new medical technology called
PET-CT which combines two imaging modalities in one device. While this technology is very new and has great potential in cancer and brain disorders, it also poses major challenges for information processing and transmission. We will address these challenges by developing advanced algorithms that optimally extract information from PET and CT using mathematical models that correct for the various sources of inaccuracy. Our research will put Australian biomedical researchers and healthcare professionals at the forefront of advanced medical imaging technology.Read moreRead less
An Innovative Multimedia Framework for Multidimensional PET-CT Image Navigation and Communication. The recent development of a combined positron emission tomography and computerized tomography (PET-CT) device ushers in a completely new era in molecular imaging that will revolutionize the approach to imaging in the clinical environment. In this project, we address a number of the critical challenges associated with the introduction of PET-CT, and provide a range of innovative multimedia technolo ....An Innovative Multimedia Framework for Multidimensional PET-CT Image Navigation and Communication. The recent development of a combined positron emission tomography and computerized tomography (PET-CT) device ushers in a completely new era in molecular imaging that will revolutionize the approach to imaging in the clinical environment. In this project, we address a number of the critical challenges associated with the introduction of PET-CT, and provide a range of innovative multimedia technologies to visualize, manipulate and deliver these multi-dimensional data. Our research will greatly enhance the clinical and research benefits of PET-CT and facilitate new discoveries which will have a significant scientific and social impact in Australia and the world at large.Read moreRead less
A new generation of multi-modality biomedical image visualisations. This research will overcome the urgent and significant burden in the routine clinical visualisation of multiple-modality biomedical image data, which are complex and exquisitely detailed from the new generation of high-resolution medical imaging scanners. Together with our industry partner RPA Hospital, we will produce 3D visualisation methodologies that will simplify and revolutionise the way biomedical data are visualised, ana ....A new generation of multi-modality biomedical image visualisations. This research will overcome the urgent and significant burden in the routine clinical visualisation of multiple-modality biomedical image data, which are complex and exquisitely detailed from the new generation of high-resolution medical imaging scanners. Together with our industry partner RPA Hospital, we will produce 3D visualisation methodologies that will simplify and revolutionise the way biomedical data are visualised, analysed and interpreted by imaging specialists and disseminated to doctors and patients. Given the pivotal role that imaging plays in modern healthcare, this will improve diagnosis and assessment, and enhance Australia's leading position in the development of frontier technologies.Read moreRead less
Large scale knowledge and image based biomedical modelling and derivation of PET-CT disease maps and treatment response. The smart use of information to improve, promote and maintain good healthcare is a critical mission for our country. Cancer is a serious problem in Australian society and 1 in 4 individuals will be affected by it in their lifetime. Our research is focussed on two types of cancer - lung cancer and the lymphomas - and it will use IT in a novel way to extract important informatio ....Large scale knowledge and image based biomedical modelling and derivation of PET-CT disease maps and treatment response. The smart use of information to improve, promote and maintain good healthcare is a critical mission for our country. Cancer is a serious problem in Australian society and 1 in 4 individuals will be affected by it in their lifetime. Our research is focussed on two types of cancer - lung cancer and the lymphomas - and it will use IT in a novel way to extract important information from a very large biomedical data repository. We hope that it will improve personalised diagnosis and treatment in these cancers and provide new information on how some cancers spread and resist our usual treatments. We think our techniques will contribute to other research areas such as astronomy, agriculture, water/energy resources, and security.Read moreRead less
Promoting ethical non-violent relationships of young women and men. The research aims to contribute to the prevention of sexual violence between young women and men aged 16-25years to promote their ability to live healthy, productive and fulfilling lives. It will provide a multidisciplinary approach to developing an evaluated educational training programme based on young people's experiences of sexual intimacy, sexuality and anti-violence education, delivery of a training programme in three rura ....Promoting ethical non-violent relationships of young women and men. The research aims to contribute to the prevention of sexual violence between young women and men aged 16-25years to promote their ability to live healthy, productive and fulfilling lives. It will provide a multidisciplinary approach to developing an evaluated educational training programme based on young people's experiences of sexual intimacy, sexuality and anti-violence education, delivery of a training programme in three rural and metropolitan sites and follow up interviews with young people six months after completion of the course.The findings of the research will inform policy makers, educators and community organisations working with young women and men.Read moreRead less
Modelling the APEC Digital Divide. Study of private sector motivation for the uptake of ICT is helpful in formulating regulatory and commercial responses to foster growth of competitive information-using and information-producing industries. The project will help clarify the relative benefits of production and use of ICT. Additionally, in an APEC context, analysis of the digital divide will inform policy appropriate to enhancing Australia's contribution to the region. The general purpose infor ....Modelling the APEC Digital Divide. Study of private sector motivation for the uptake of ICT is helpful in formulating regulatory and commercial responses to foster growth of competitive information-using and information-producing industries. The project will help clarify the relative benefits of production and use of ICT. Additionally, in an APEC context, analysis of the digital divide will inform policy appropriate to enhancing Australia's contribution to the region. The general purpose information technology of the Internet network is fast evolving into the enabling technology of choice for innovation and creative applications of a platform for communication and electronic transactions.Read moreRead less
Information Technology Aided Diagnosis of Dementia with PET-CT Imaging. Dementia is a significant health problem and approximately 162,000 Australians currently suffer from this disease, with costs estimated at $6 billion annually in Australia and a profound effect on the lives of carers and family members. With the ageing of the Australian population, the patient number is expected to rise to 500,000 by 2040.This research will apply innovative IT approaches to develop computer assisted diagnosi ....Information Technology Aided Diagnosis of Dementia with PET-CT Imaging. Dementia is a significant health problem and approximately 162,000 Australians currently suffer from this disease, with costs estimated at $6 billion annually in Australia and a profound effect on the lives of carers and family members. With the ageing of the Australian population, the patient number is expected to rise to 500,000 by 2040.This research will apply innovative IT approaches to develop computer assisted diagnosis of early dementia, when treatment is possible, from combined functional and anatomical imaging modalities (PET-CT). This will not only add considerable value to Australia's medical imaging infrastructure and smart use of information, but will ultimately also deliver substantial benefits to our nation and community.Read moreRead less
The Costs of Foster Care in Australia. The aim of the study is to determine adequate and appropriate levels of reimbursement for carers by undertaking empirical research on the economic and social costs associated with fostering. For the first time in Australia the indirect costs to carers will be examined and a model developed for reimbursing foster carers similar to other paid carers in the community. In collaboration with the Industry Partner it will explore the feasibility of using budget st ....The Costs of Foster Care in Australia. The aim of the study is to determine adequate and appropriate levels of reimbursement for carers by undertaking empirical research on the economic and social costs associated with fostering. For the first time in Australia the indirect costs to carers will be examined and a model developed for reimbursing foster carers similar to other paid carers in the community. In collaboration with the Industry Partner it will explore the feasibility of using budget standards methodology to estimate the direct costs of care of children by refining and adapting budgets to reflect costs specific to different types of foster care.Read moreRead less
Integrated multi-level interpretation and its applications for intelligent multimodality biomedical image navigation, retrieval and tracking. The 64- and 128-slice positron emission tomography – computed tomography (PET-CT) devices at the Royal Prince Alfred Hospital were the first in the country. These scanners, with the medical cyclotron and radiochemistry facilities, represent an investment of over A$13 million. This project will address pressing issues in optimising the utilisation of the in ....Integrated multi-level interpretation and its applications for intelligent multimodality biomedical image navigation, retrieval and tracking. The 64- and 128-slice positron emission tomography – computed tomography (PET-CT) devices at the Royal Prince Alfred Hospital were the first in the country. These scanners, with the medical cyclotron and radiochemistry facilities, represent an investment of over A$13 million. This project will address pressing issues in optimising the utilisation of the information and systems to provide better service to patients and referring clinicians. This research will add considerable value to Australia's medical imaging infrastructure and healthcare delivery; and advance scientific research in better understanding of system biology, physiology and pathology. The research outcomes will strengthen Australia’s leading position in biomedical information technology research and Australian medical imaging expertise.Read moreRead less