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This program will investigate the strategies used by pathogenic bacteria to cause human diseases. The research will focus on how bacteria initiate infections, how they invade, cause cell and tissue damage and respond to their human host. It will also examine how the host’s innate immune system interacts with these bacteria. The results will provide new insights into host-pathogen interactions and reveal new targets for the development of novel antibacterial drugs and vaccines.
Examining the relationship between error processing, cognitive control and emotion: a cognitive neuroscience approach. The proposed research aims to contribute to current scientific thinking on how the processing of errors influences self-monitoring and cognitive performance. The ability to monitor one's cognitive performance deteriorates with normal ageing, and is particularly affected in a range of clinical conditions, where it is a reliable predictor of a poor prognostic outcome. This project ....Examining the relationship between error processing, cognitive control and emotion: a cognitive neuroscience approach. The proposed research aims to contribute to current scientific thinking on how the processing of errors influences self-monitoring and cognitive performance. The ability to monitor one's cognitive performance deteriorates with normal ageing, and is particularly affected in a range of clinical conditions, where it is a reliable predictor of a poor prognostic outcome. This project aims to clarify understanding of the cognitive and neural processes underlying self-monitoring, as an important first step to improving rehabilitation and management methods for age-related impairments such as Alzheimer's disease, and prominent mental health conditions such as schizophrenia.Read moreRead less
Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect ....Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect their activity, and how they affect cellular function, tissue morphology and particle transport in a biological milieu. The project is expected to benefit the advanced manufacturing, veterinary and medical sectors and could lead to new chemotherapeutics.Read moreRead less
Sociophysical Interactions: understanding the role of social and tangible technologies in maintaining good habits into old age. How can technology help us 'age well'? The project will study, design and evaluate novel information systems that integrate and support social engagement and physical activity in order to build foundational knowledge about these technologies and maintain the opportunities for social engagement and physical activity in our ageing population.
Characterisation and improvement of radiation beams used for radiotherapy of small lesions. This project aims to characterise the radiation dose from a medical linear accelerator after the beam has been shaped by a mini-multileaf collimator. The characterisation will be achieved through a combination of computer simulations and experimental investigation of the beam using the technique of three-dimensional gel dosimetry. When the dosage characteristics are known, techniques will be developed to ....Characterisation and improvement of radiation beams used for radiotherapy of small lesions. This project aims to characterise the radiation dose from a medical linear accelerator after the beam has been shaped by a mini-multileaf collimator. The characterisation will be achieved through a combination of computer simulations and experimental investigation of the beam using the technique of three-dimensional gel dosimetry. When the dosage characteristics are known, techniques will be developed to improve radiotherapy treatments in patients with small lesions with sizes of up to a few centimetres. This will lead to an improved outcome for some cancer patients.Read moreRead less
Assessing risk in aged mental health care. This study will explore practices and developments in relation to the assessment of risk in aged persons mental health from the perspective of multiple stakeholders. The aims are to gain a thorough understanding of existing practices with a view to developing and evaluating a comprehensive risk assessment model. The outcomes will enhance the provision of mental health services within aged mental health services.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453623
Funder
Australian Research Council
Funding Amount
$164,640.00
Summary
Peripheral quantitative computed tomography facility for analysing bone material and structural properties. We aim to establish a facility that allows non-invasive measurement of apparent material and structural properties of small animal and human bone using leading-edge technology, peripheral quantitative computed tomography (pQCT). pQCT measurements, incorporated into our fundamental bone research will improve our understanding of the role of mechanical, environmental and local factors in re ....Peripheral quantitative computed tomography facility for analysing bone material and structural properties. We aim to establish a facility that allows non-invasive measurement of apparent material and structural properties of small animal and human bone using leading-edge technology, peripheral quantitative computed tomography (pQCT). pQCT measurements, incorporated into our fundamental bone research will improve our understanding of the role of mechanical, environmental and local factors in regulating bone and mineral metabolism and altering bone properties. This has implications for maximising bone strength and promoting optimal health throughout life. The facility will be used for a diverse range of multidisciplinary basic bone research and is vital in order to maintain international competitiveness in the field.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237723
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Argus On-Line: A Nineteenth Century Australian Newspaper Digital Index. This project seeks to develop a searchable digital index to the original texts of the Argus print run for the ten years 1870-1879, and make it accessible through the world wide web in 2002. The digital index will, for the first time, make the contents of a late nineteenth century Australian newspaper widely available to researchers of Australia, thus creating a resource of national significance. The digital index will suppor ....Argus On-Line: A Nineteenth Century Australian Newspaper Digital Index. This project seeks to develop a searchable digital index to the original texts of the Argus print run for the ten years 1870-1879, and make it accessible through the world wide web in 2002. The digital index will, for the first time, make the contents of a late nineteenth century Australian newspaper widely available to researchers of Australia, thus creating a resource of national significance. The digital index will support major national research projects. It will serve as a foundation for the development of a complete digital index to the newspaper over the years 2003-2005.Read moreRead less
The MYB gene as a model for global transcriptional regulation: stopping, starting and looping. This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with res ....The MYB gene as a model for global transcriptional regulation: stopping, starting and looping. This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with respect to transcriptional elongation and long-range regulation. It will highlight a new approach to the therapeutic targeting of MYB in cancer: data generated from this research may enable us to target MYB expression in a range of cancers including breast cancer by inhibiting transcriptional elongation. And it will provide training in advanced molecular biology to postdoctoral scientists and students.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453714
Funder
Australian Research Council
Funding Amount
$205,800.00
Summary
Argus On-Line: A Nineteenth Century Australian Newspaper Digital Index. This project is developing a searchable digital index to the Argus newspaper for the period 1870-1909, and to make it accessible through the world-wide web. The digital index will, for the first time,make the contents of a late nineteenth century Australian newspaper widely available to researchers of Australia, thus creating a resource of national significance. The digital index will support major national research projects ....Argus On-Line: A Nineteenth Century Australian Newspaper Digital Index. This project is developing a searchable digital index to the Argus newspaper for the period 1870-1909, and to make it accessible through the world-wide web. The digital index will, for the first time,make the contents of a late nineteenth century Australian newspaper widely available to researchers of Australia, thus creating a resource of national significance. The digital index will support major national research projects in many fields. A complete digital index will be subsequently created by placing existing printed indexes (1846-69, 1909-49) on line.Read moreRead less