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Understanding the molecular mechanism of force generation in the bacterial flagellar motor. The proposed research will advance the knowledge about how the bacterial flagellar motor works, enabling scientists to learn more about nature's blueprint of a nanoscale engine. It will address the fundamental question of how bacterial cells convert electrochemical energy into mechanical energy of rotation. At present, the smallest artificial electric motor is still on a micro-, rather than nanoscale. Nan ....Understanding the molecular mechanism of force generation in the bacterial flagellar motor. The proposed research will advance the knowledge about how the bacterial flagellar motor works, enabling scientists to learn more about nature's blueprint of a nanoscale engine. It will address the fundamental question of how bacterial cells convert electrochemical energy into mechanical energy of rotation. At present, the smallest artificial electric motor is still on a micro-, rather than nanoscale. Nanotechnology would therefore benefit from this work by basing their designs on the principles behind the mechanism of the bacterial motor. This research is also of interest for veterinary science, as motility by flagellar motor is a key virulence factor of common animal pathogens associated with, for example, listeriosis and gastroenteritis.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775708
Funder
Australian Research Council
Funding Amount
$289,680.00
Summary
X-ray Diffraction Microscope. The results of the research will substantially expand Australia's knowledge base in the area of diffraction, imaging and structural biology. It will build up our expertise in x-ray optics and synchrotron technology, and will open up a new approach to x-ray imaging and structure determination.
This will revolutionize our understanding of cellular and sub-cellular organisation with implications for the treatment of disease while the ability to determine structures ....X-ray Diffraction Microscope. The results of the research will substantially expand Australia's knowledge base in the area of diffraction, imaging and structural biology. It will build up our expertise in x-ray optics and synchrotron technology, and will open up a new approach to x-ray imaging and structure determination.
This will revolutionize our understanding of cellular and sub-cellular organisation with implications for the treatment of disease while the ability to determine structures of membrane proteins will open the door to fresh opportunities in rational drug design and biotechnology that will promote innovation in this industry, and the likely foundation of new start-up companies.Read moreRead less
Ultrahigh resolution crystallography and ultrafast laser spectroscopy to uncover the evolution and mechanisms of a unique algal light harvesting system. The results of our research will provide the first comprehensive understanding of a biological light harvesting system at high temporal, energetic and spatial resolution. This will allow us to understand how nature has evolved highly efficient strategies for trapping light. The benefits of this work include spawning ideas as to how to improve ....Ultrahigh resolution crystallography and ultrafast laser spectroscopy to uncover the evolution and mechanisms of a unique algal light harvesting system. The results of our research will provide the first comprehensive understanding of a biological light harvesting system at high temporal, energetic and spatial resolution. This will allow us to understand how nature has evolved highly efficient strategies for trapping light. The benefits of this work include spawning ideas as to how to improve current technologies for enhancing optoelectronic devices and solar collectors. Protein systems are by nature nanotechnology. The understanding gained through probing a natural nanosystem will enhance our understanding of how human designed nanophotonic systems will behave. Read moreRead less
Functional Dissection of the Bacterial Replisome. We now have the complete sequences of genes in humans and many other organisms, but we know much less about how the protein products of the genes communicate with each other to create and grow cells. Australia has recently invested heavily in state-of-the-art instruments that can be used to tackle these problems. This project will involve close interaction of four laboratories to use new instruments to determine how a large assembly of proteins i ....Functional Dissection of the Bacterial Replisome. We now have the complete sequences of genes in humans and many other organisms, but we know much less about how the protein products of the genes communicate with each other to create and grow cells. Australia has recently invested heavily in state-of-the-art instruments that can be used to tackle these problems. This project will involve close interaction of four laboratories to use new instruments to determine how a large assembly of proteins interact in a biological machine that makes DNA. This process occurs in similar ways in all organisms, and is essential for life. Understanding how DNA is made will help scientists to develop new antibacterial drugs, and learn how to make practical use of molecular machines that imitate biology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882382
Funder
Australian Research Council
Funding Amount
$245,000.00
Summary
Biophysical Characterisation Facility. The protein analysis facility will have substantial benefits for basic science and biotechnology. It will create capacity for South Australian researchers to study proteins at the biophysical level. The facility will support research projects within the designated national research priority areas of 'Frontier technologies for building and transforming Australian industries' and 'Promoting and maintaining good health
Mechanism of glutamate transport from experimental and simulation studies. Glutamate transporters play key roles in shaping the electrical signaling in the brain. Under conditions of stress or after a stroke, glutamate transporter function is impaired, which can lead to excessive levels of glutamate, cell death and impaired brain function. The project will help to decipher the operation of glutamate transporters at a molecular level and provide greater understanding of how glutamate levels are c ....Mechanism of glutamate transport from experimental and simulation studies. Glutamate transporters play key roles in shaping the electrical signaling in the brain. Under conditions of stress or after a stroke, glutamate transporter function is impaired, which can lead to excessive levels of glutamate, cell death and impaired brain function. The project will help to decipher the operation of glutamate transporters at a molecular level and provide greater understanding of how glutamate levels are controlled, which is vital for developing better treatments for neurological disorders such as stroke. The project will also provide research training in experimental/computational molecular biology, which is a rapidly growing field underpinning the biotechnological and pharmaceutical industries. Read moreRead less
Hierarchical modeling of protein interactions. Protein interactions play a central role in function and structural organization of cells. Their elucidation is essential for a better understanding of many cellular processes from signal transduction to enzyme inhibition. The aim of this project is to utilize the unprecedented powers of current supercomputers in developing a hierarchical model of protein interactions. The method combines Brownian dynamics at large distances and long time scales ....Hierarchical modeling of protein interactions. Protein interactions play a central role in function and structural organization of cells. Their elucidation is essential for a better understanding of many cellular processes from signal transduction to enzyme inhibition. The aim of this project is to utilize the unprecedented powers of current supercomputers in developing a hierarchical model of protein interactions. The method combines Brownian dynamics at large distances and long time scales with molecular dynamics at small distances and shorter times. Applications to both membrane proteins (blocking of ion channels by toxins and drugs) and globular proteins (ligand binding to receptors and protein association) will be considered.Read moreRead less
THE BIOLOGY OF COLD ADAPTED EXTREMOPHILES: AN INTEGRATED GENOMIC-PROTEIN ANALYSIS APPROACH. Extremophiles are microorganisms that can thrive in otherwise inhospitable environments. Most extremophiles are Archaea; an order of life separate from Bacteria and Eucaryotes. The project will generate the first genome sequence that was initiated in Australia, and the first genome sequence of any cold adapted organism. Associated functional studies include global analyses of protein expression (proteo ....THE BIOLOGY OF COLD ADAPTED EXTREMOPHILES: AN INTEGRATED GENOMIC-PROTEIN ANALYSIS APPROACH. Extremophiles are microorganisms that can thrive in otherwise inhospitable environments. Most extremophiles are Archaea; an order of life separate from Bacteria and Eucaryotes. The project will generate the first genome sequence that was initiated in Australia, and the first genome sequence of any cold adapted organism. Associated functional studies include global analyses of protein expression (proteomics) and mRNA expression using micro-arrays, and work targeted at RNA binding proteins and protein folding systems involved in the thermally sensitive process of protein synthesis. The nature and scope of the work will impact on fundamental cellular processes and provide enormous innovative biotechnological potential.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882855
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
High-resolution imaging of live cells and tissue. Understanding the machinery of life and developing technologies that support life's processes requires biological and physical scientists and engineers to monitor molecular events in living systems. The aim is to take advantage of very recent developments in light microscopy to enable the non-invasive imaging of live cells and tissue at a previously unreachable level of detail. The instruments will form the nucleus of a new imaging facility. Sign ....High-resolution imaging of live cells and tissue. Understanding the machinery of life and developing technologies that support life's processes requires biological and physical scientists and engineers to monitor molecular events in living systems. The aim is to take advantage of very recent developments in light microscopy to enable the non-invasive imaging of live cells and tissue at a previously unreachable level of detail. The instruments will form the nucleus of a new imaging facility. Significant advances in research areas including vascular research, cancer, immunology, cell and molecular biology, functional genomics, biotechnology, nanotechnology and material engineering will be of major benefit both nationally and globally.Read moreRead less
Studies of the Dynamic Language of Bio-Molecular Communication and Signalling. For normal biological function, a multitude of external signals must be interpreted and responded to by cells. The responses must be carefully regulated and coordinated, or else pathological conditions will develop and, if not corrected, lead to uncontrolled proliferation or cell death. This project studies the mechanisms by which cells transmit signals. Proteins accomplish this communication by modifying the inter ....Studies of the Dynamic Language of Bio-Molecular Communication and Signalling. For normal biological function, a multitude of external signals must be interpreted and responded to by cells. The responses must be carefully regulated and coordinated, or else pathological conditions will develop and, if not corrected, lead to uncontrolled proliferation or cell death. This project studies the mechanisms by which cells transmit signals. Proteins accomplish this communication by modifying the interactions among their functional domains, effectively creating a conformational language. Knowledge of this language will impact biomedicine through its contributions to understanding the molecular pathology of diseased states, and biotechnology by enhancing our ability to use biological processes for applications.Read moreRead less