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About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock a ....About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock and its role in the normal biology of the heart. New data will significantly enhance our understanding of the biology of MR and cortisol for the circadian time keeping function in peripheral tissues, and gain a clearer understand how our heart cells adapt to environmental circadian disruptors such as shift work. Read moreRead less
Long range interactions of atoms. Atomic physics is often described as both a basic and enabling discipline and the present project on long range atomic interactions fits within both of those categories. The results of the project will lead to a more thorough understanding of the details of long range atom-atom interactions. This will lead to Australian expertise making a significant contribution in a number of cutting edge areas in atomic and molecular physics.
Application of variational methods in atomic and molecular physics. Atmoic physics is both a basic an enabling science and this project will improve fundamental knowledge about the interactions of electrons and positrons with atoms and molecules. Research will be directly relevant to the activities of the National Positron Beam-Line (located at the Australian National University) which is directed to break-through research in matter-antimatter interactions and materials characterisation.
....Application of variational methods in atomic and molecular physics. Atmoic physics is both a basic an enabling science and this project will improve fundamental knowledge about the interactions of electrons and positrons with atoms and molecules. Research will be directly relevant to the activities of the National Positron Beam-Line (located at the Australian National University) which is directed to break-through research in matter-antimatter interactions and materials characterisation.
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Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying ....Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying regulators of lipid metabolism. The large diversity in humans necessitate sufficient sample sizes to identify true genetic regulators, but to date techniques capturing phenotypic data (lipids) have been largely limited. It is anticipated that this study will identify new regulators of lipid metabolism in humans.Read moreRead less
Water-use efficiency of Australian tropical trees: mechanistic analysis at multiple scales. The proposed research will provide valuable information about the physiological functioning of trees in northern Australia. Experiments will elucidate mechanisms that can result in variation in water-use efficiency among different tree species. Such a mechanistic understanding will have multiple benefits: (1) results will be able to be incorporated into process-based models of carbon and water cycling ....Water-use efficiency of Australian tropical trees: mechanistic analysis at multiple scales. The proposed research will provide valuable information about the physiological functioning of trees in northern Australia. Experiments will elucidate mechanisms that can result in variation in water-use efficiency among different tree species. Such a mechanistic understanding will have multiple benefits: (1) results will be able to be incorporated into process-based models of carbon and water cycling in the north-Australian landscape; (2) they will provide valuable information for land managers interested in optimizing both plant biomass production and water resource management; and (3) they will provide a critical test of proxy methods for identifying high water-use efficiency in taxonomically diverse tree species.Read moreRead less
Australian savannah landscapes: past, present and future. Australian savannahs are productive and culturally and biologically significant landscapes but are vulnerable to climate change. The project will determine savannah function (carbon and water balance) for the present and assess how sensitive they have been to past climate variability. The project will then address how they may respond to future climate change.
Skin Microbes and Animal Health: Understanding the Ecological Context. This project aims to understand the fundamental ecological relationships between animal hosts (frogs, geckos) and bacteria on their skin by separating host effects from environmental factors that determine skin microbiome composition. The research is significant because it will generate new knowledge needed to understand how skin microbes function in providing protection against disease. Expected outcomes include the provisio ....Skin Microbes and Animal Health: Understanding the Ecological Context. This project aims to understand the fundamental ecological relationships between animal hosts (frogs, geckos) and bacteria on their skin by separating host effects from environmental factors that determine skin microbiome composition. The research is significant because it will generate new knowledge needed to understand how skin microbes function in providing protection against disease. Expected outcomes include the provision of essential information that will guide future research efforts on the factors that determine a healthy skin microbial community (which is needed before skin diseases can be combated). The research will provide significant benefits, including more targeted conservation efforts to combat wildlife skin diseases.Read moreRead less
Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We ....Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We will generate antibody fragments that bind these MP and express them in tomato. We will analyse antibody expression in tomato and study their association with the phytoplasma membrane. Transgenic plants will be inoculated with phytoplasma and monitored for resistance. This work represents a major step towards engineering resistance to phytoplasmas.Read moreRead less
Are evolutionary refugia traps for endemic species? This project aims to determine whether species that have small geographic ranges and which live in historically stable refugia have evolved narrow climatic tolerances. The project will compare such species with more widespread, related species living in the same areas and combine field- and lab-based estimates of physiological tolerances with genomic estimates of population history and diversity. The expected outcome is to test the prediction f ....Are evolutionary refugia traps for endemic species? This project aims to determine whether species that have small geographic ranges and which live in historically stable refugia have evolved narrow climatic tolerances. The project will compare such species with more widespread, related species living in the same areas and combine field- and lab-based estimates of physiological tolerances with genomic estimates of population history and diversity. The expected outcome is to test the prediction from evolutionary theory that small-range, refugial species are intrinsically more sensitive to climatic change. The project expects to provide improved guidance for ecological management of biodiversity hotspots.Read moreRead less
Improving the Governance of Species Lists. The aim of this project is to develop a system of governance for the creation of taxonomic lists. This project expects to apply knowledge of how other science organizations govern themselves to the governance of taxonomic lists, estimate the costs of current inefficiencies and identify impediments to improvement. Expected outcomes of this project include a process for validating global lists of species. This should provide significant benefits, such as ....Improving the Governance of Species Lists. The aim of this project is to develop a system of governance for the creation of taxonomic lists. This project expects to apply knowledge of how other science organizations govern themselves to the governance of taxonomic lists, estimate the costs of current inefficiencies and identify impediments to improvement. Expected outcomes of this project include a process for validating global lists of species. This should provide significant benefits, such as single lists of species that can be adopted at any scale and are readily comparable across countries and applications. A single list will ensure threatened species and those of quarantine or health concern don’t fall through the cracks and cause problems.Read moreRead less