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I am a structural biologist with a background in pharmacy. My research focuses on dissecting the molecular mechanisms of disease-causing proteins to underpin the development of new and improved therapeutics
Malaria is a devastating disease of global significance. With mounting resistance to current drugs and no licensed malaria vaccine, there is a pressing need to search for new strategies to reduce the global burden of malaria. My research program aims to understand how the parasites that cause malaria extensively renovate the cells in which they reside and subvert their host so that they can thrive and survive, with a view to identifying new pathways that can be targeted by drugs or vaccines.
Molecular Approaches To Cardiac Development, Disease And Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$863,910.00
Summary
Prof Harvey’s work explores the molecular and cellular networks that underpin heart development in the embryo and heart regeneration in the adult, and how these networks unravel in heart disease. Based on this knowledge, his work seeks to develop novel approaches for alleviating suffering in babies with congenital heart defects and adults enduring the devastating consequences of heart attack or heart failure.
Cracking The Epigenetic Code: Understanding The Mechanisms Of Memory Associated With Anxiety-related Disorders And Their Treatment
Funder
National Health and Medical Research Council
Funding Amount
$640,210.00
Summary
The primary goal of my research programme is to elucidate how the epigenome coordinates experience-dependent gene expression underlying associative learning and memory using paradigms relevant for understanding fear-related anxiety disorders. My research on DNA modifications and newly emerging findings in the realm of RNA biology is changing the way we think about gene-environment interactions, the broader impact of which will most certainly continue to be felt for years to come.
Prof Khachigian is a vascular cell and molecular biologist elucidating fundamental transcriptional mechanisms that lead to the inappropriate expression of harmful genes in vascular cells. Exploiting this science, I am also a “translational” researcher who has pioneered the development of novel strategies targeting key regulatory genes to combat angiogenesis-dependent cancers, and potentially other common vascular disorders such as post-angioplasty restenosis, bypass graft stenosis, ocular neovas ....Prof Khachigian is a vascular cell and molecular biologist elucidating fundamental transcriptional mechanisms that lead to the inappropriate expression of harmful genes in vascular cells. Exploiting this science, I am also a “translational” researcher who has pioneered the development of novel strategies targeting key regulatory genes to combat angiogenesis-dependent cancers, and potentially other common vascular disorders such as post-angioplasty restenosis, bypass graft stenosis, ocular neovascularisation and rheumatoid arthritis.Read moreRead less
Immunological Diseases: Understanding Their Cause And Improving Their Treatment By Human Genome Sequencing
Funder
National Health and Medical Research Council
Funding Amount
$788,486.00
Summary
Prof Goodnow will develop a collaborative consortium of specialist physicians, laboratory researchers and bioinformaticians. This team will apply the new tools of large scale DNA sequencing to reveal the root cause of immune system diseases including: autoimmune diseases, congenital immune deficiency diseases, allergic disorders, and cancer. It aims to accelerate, simplify and unify the diagnosis of these diseases, and guide targeted, earlier and more effective treatment.
The blood system is made up of different types of blood cells (red cells, white cells, platelets etc). The correct number of each type of cell is controlled by chemical messengers called cytokines. Because overactive cytokine signalling can lead to inflammatory disease and leukemia it is tightly controlled by the other molecules in the body. This project aims to determine the exact mechanism whereby this is achieved with the aim of developing therapies to treat inflammatory disease and leukemia.
Relaxin family peptides are small proteins that have numerous essential biological roles in the vascular system, brain and gut. The hormone relaxin is currently in Phase III clinical trials to treat heart failure and the other peptides show great potential as drugs to treat diseases including mental illnesses and obesity. My research focuses on developing drugs targeting the receptors for these important peptide systems and understanding how these drugs can be best used therapeutically
The Ghost In The Machine: Understanding How Haemostasis Is Regulated By Allosteric Disulphide Bonds
Funder
National Health and Medical Research Council
Funding Amount
$898,008.00
Summary
Genes encode proteins, which are the machinery of life. All life forms make proteins that contain bonds between pairs of cysteine amino acids called disulphide bonds. Prof Hogg has discovered a type of disulphide bond, the allosteric disulphide, which controls how proteins work by breaking or forming in a precise way. His research aim is to define how haemostasis is controlled by allosteric disulphides. Haemostasis gone wrong leads to heart attack and stroke.