Harnessing Information Technology To Improve Self-management Behaviours And Health Outcome In People With Heart Failure: A Smarthome Ecosystem Living Lab Study
Funder
National Health and Medical Research Council
Funding Amount
$1,120,226.00
Summary
The burden of heart failure in Australia is substantial. Management of heart failure is complex and requires self-management of symptoms and behaviour change, which requires ongoing education and support to achieve. Current approaches for supporting self-management do not meet the needs of people with heart failure or the healthcare system. This Australian first project aims to co-design an intelligent smart home ecosystem (Smart Heart) to support the management for people with heart failure.
Novel Therpeutic Approaches For Alzheimers Disease
Funder
National Health and Medical Research Council
Funding Amount
$604,734.00
Summary
There are currently no effective treatments for Alzheimer's disease. In this application we will develop a novel class of compound to assess their potential as AD therapeutics. These compounds will be tested in vitro and in vivo models of Alzheimer's disease. The successful conclusion of the work described here would provide new leads suitable for further development as therapeutics for Alzheimer's disease.
Fabrication and Application of Ion-Sensors Based on the Voltammetry of Nanocrystals Adhered to Electrode Surfaces. A significant need exists for the low cost determination of cations and anions in biologically (blood, urine), industrially (process streams) and environmentally (rivers, lakes) important fluids. In this project, skills in sensor design, scientific instrumentation, materials science, electrochemistry and analytical science provided by a consortium of scientists at Monash University ....Fabrication and Application of Ion-Sensors Based on the Voltammetry of Nanocrystals Adhered to Electrode Surfaces. A significant need exists for the low cost determination of cations and anions in biologically (blood, urine), industrially (process streams) and environmentally (rivers, lakes) important fluids. In this project, skills in sensor design, scientific instrumentation, materials science, electrochemistry and analytical science provided by a consortium of scientists at Monash University, the Victorian Institute for Chemical Sciences, Oxford Biosensors and Oxford University will be integrated to fabricate and develop applications of commercially viable ion-sensing systems. The principles to be utilised are based on novel forms of voltammetry of nanocrystals adhered to electrode surfaces.Read moreRead less
Amelioration strategies to reduce environmental deterioration and agricultural production losses in water repellent regions. Millions of hectares of potentially productive agricultural land in Australia are affected by water-repellency. Water repellency causes non-uniform infiltration of water in soils and promotes surface erosion. Consequently, water repellent soils cannot be satisfactorily used for agricultural production, resulting in production losses of millions of dollars annually. This in ....Amelioration strategies to reduce environmental deterioration and agricultural production losses in water repellent regions. Millions of hectares of potentially productive agricultural land in Australia are affected by water-repellency. Water repellency causes non-uniform infiltration of water in soils and promotes surface erosion. Consequently, water repellent soils cannot be satisfactorily used for agricultural production, resulting in production losses of millions of dollars annually. This investigation is part of a genuine international effort that will develop new procedures to ameliorate water-repellent soils. New and improved mathematical models and decision support tools will also be developed to improve water-repellent land management, reduce environmental risk and minimise agriculture production loss.Read moreRead less
Probing the function of protein molecular motors on nano-fabricated structures. The function of protein linear molecular motors, which are natural dynamic bio-nano-devices with a ubiquitous importance in multicellular organisms, will be 'probed' with purposefully designed nano-structures fabricated via photo- or Scanning Probe Microscopy Lithography, that is, flat polymeric surfaces with combinatorial combinations of physico-chemistries; and micro/nano-channels and nano-wells with critical dimen ....Probing the function of protein molecular motors on nano-fabricated structures. The function of protein linear molecular motors, which are natural dynamic bio-nano-devices with a ubiquitous importance in multicellular organisms, will be 'probed' with purposefully designed nano-structures fabricated via photo- or Scanning Probe Microscopy Lithography, that is, flat polymeric surfaces with combinatorial combinations of physico-chemistries; and micro/nano-channels and nano-wells with critical dimensions similar to the scale of the probed biomolecules. The project turns 'up-side down' the challenge of invasive nano-probing of biomolecules using it in an engineered manner. The fundamental understanding of linear molecular motors will impact on biomedical science and on the assessment of hybrid natural-artificial dynamic nano-devices.Read moreRead less
Using 3D printing to improve access to graphics by vision-impaired people. This project aims to investigate the possible benefits of 3D printing for production of accessible materials for vision-impaired people. Currently tactile graphics are used to provide severely vision-impaired adults and children with access to graphical content used in education and in orientation and mobility training. This project is expected to clarify the kinds of graphics for which 3D prints are better suited than ta ....Using 3D printing to improve access to graphics by vision-impaired people. This project aims to investigate the possible benefits of 3D printing for production of accessible materials for vision-impaired people. Currently tactile graphics are used to provide severely vision-impaired adults and children with access to graphical content used in education and in orientation and mobility training. This project is expected to clarify the kinds of graphics for which 3D prints are better suited than tactile graphics, and to build capacity within the national accessible format provision sector for the production and use of 3D prints. Benefits will include increased educational opportunities and quality of life for Australians with severe vision impairment, through improved access to graphic materials used in education and orientation and mobility training.
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Overcoming the Barriers in the Development of Solid State Materials. A major impact of this proposal shall be in terms of researcher training. By synergistically combining materials chemistry, fundamental physical chemistry, inorganic chemistry, and electrochemistry, this basic program will provide high level training to a new generation of Australian and Irish scientists thus helping to safeguard the economic competitiveness of the countries. Beyond the impact of the fundamental insight into t ....Overcoming the Barriers in the Development of Solid State Materials. A major impact of this proposal shall be in terms of researcher training. By synergistically combining materials chemistry, fundamental physical chemistry, inorganic chemistry, and electrochemistry, this basic program will provide high level training to a new generation of Australian and Irish scientists thus helping to safeguard the economic competitiveness of the countries. Beyond the impact of the fundamental insight into the rational design, structure and behaviour of a new class of solid materials, success in this program will have widespread applications for a variety of strategically important industries and should place Australia and Ireland at the forefront of this technologyRead moreRead less
Drought and Salinity Tolerance in Metal Hyperaccumulating Plants: A Functional Role for the Metals? A few plant species can ?hyperaccumulate? metal ions to 100-1000 times the concentrations seen in ?normal? plants. Just why these plants have evolved such an extreme response to metalliferous soils remains an enigma. Many of the hyperaccumulators so far described are endemic to xeric environments, or saline soils prone to rapid drying. We hypothesize that the metals might act as osmotica, enha ....Drought and Salinity Tolerance in Metal Hyperaccumulating Plants: A Functional Role for the Metals? A few plant species can ?hyperaccumulate? metal ions to 100-1000 times the concentrations seen in ?normal? plants. Just why these plants have evolved such an extreme response to metalliferous soils remains an enigma. Many of the hyperaccumulators so far described are endemic to xeric environments, or saline soils prone to rapid drying. We hypothesize that the metals might act as osmotica, enhancing plant survival during water stress. This will be tested for Australian native and non-native hyperaccumulator plants. The study will clarify our understanding of the evolutionary significance of hyperaccumulation, and has important applications for extracting metals from contaminated soils.Read moreRead less
New Membrane Chips For Protein Interaction Analysis. This proposal is based on a strategic partnership between Monash University and Farfield Sensors. We will create a series of new biosensors that will be used to establish a new approach to the structural analysis of membrane protein function. In particular, this technology may lead to the identification of new proteins and drug targets for therapeutic development. The long-term outcome would be the development of improved therapeutics which wo ....New Membrane Chips For Protein Interaction Analysis. This proposal is based on a strategic partnership between Monash University and Farfield Sensors. We will create a series of new biosensors that will be used to establish a new approach to the structural analysis of membrane protein function. In particular, this technology may lead to the identification of new proteins and drug targets for therapeutic development. The long-term outcome would be the development of improved therapeutics which would be coupled to potential economic returns when further commercialisation is achieved. Read moreRead less
Generation of Ultra-Clean Fuel from Victorian Brown Coal and Its Oxygen-Enriched Combustion Characteristics. Completion of this project can significantly contribute to the national priority of developing alternative energy technologies and ecologically sustainable power generation systems, as well as provide solutions to reduce and capture greenhouse gas emissions during Victorian brown coal firing. Improvements in the quality of Victorian brown coal and its value in national/international trad ....Generation of Ultra-Clean Fuel from Victorian Brown Coal and Its Oxygen-Enriched Combustion Characteristics. Completion of this project can significantly contribute to the national priority of developing alternative energy technologies and ecologically sustainable power generation systems, as well as provide solutions to reduce and capture greenhouse gas emissions during Victorian brown coal firing. Improvements in the quality of Victorian brown coal and its value in national/international trade markets can be achieved through the generation of ultra-clean fuel from coal. Substitution of ultra-clean fuel for Victorian brown coal in energy industries would greatly improve the competitiveness of the Victorian economy in a carbon-constrained future, and ensure power generation near-zero emissions.Read moreRead less