A multi-metal ion sensor for analysis of environmental water. The aim of this research project is to develop an electrochemical sensor array on a single chip for the detection of several heavy metals in wastewater samples. Each electrode in the array will be modified with a different metal-binding peptide ligand; resulting in a characteristic response pattern for a given metal ion. Deconvolution of the sensor response into the response patterns of the individual metals will be achieved using p ....A multi-metal ion sensor for analysis of environmental water. The aim of this research project is to develop an electrochemical sensor array on a single chip for the detection of several heavy metals in wastewater samples. Each electrode in the array will be modified with a different metal-binding peptide ligand; resulting in a characteristic response pattern for a given metal ion. Deconvolution of the sensor response into the response patterns of the individual metals will be achieved using pattern recognition software employing artificial neural networks and other multivariate techniques. Successful development of the multi-analyte sensor will allow the rapid monitoring of environmentally important metal ions in the field.Read moreRead less
New Strategies for Monitoring DNA-Anticancer Drug Interactions. The highly successful cisplatin works by binding to DNA and partially unwinding or bending the DNA. As a consequence of the success if cisplatin, alternative anticancer drugs are being developed with reduced side effects for patients. One of the bottom necks in the development of alternative drugs is rapid screening of the efficacy on new leads. The proposed research will develop new technologies for monitoring DNA-drug binding, ....New Strategies for Monitoring DNA-Anticancer Drug Interactions. The highly successful cisplatin works by binding to DNA and partially unwinding or bending the DNA. As a consequence of the success if cisplatin, alternative anticancer drugs are being developed with reduced side effects for patients. One of the bottom necks in the development of alternative drugs is rapid screening of the efficacy on new leads. The proposed research will develop new technologies for monitoring DNA-drug binding, DNA damage and DNA repair using novel DNA biosensors. the novelty of the biosensor technology will be to use the modulation of charge transfer through DNA as a method for determining the structural changes that occur in DNA due to these events occurring.Read moreRead less