How Genetic And Environmental Risk Factors Interactively Impact On Animal Models For Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
The proposed research will clarify to what degree a genetic predisposition to schizophrenia alters the response to environmental risk factors (e.g. social stress and drugs of abuse) or interacts with them. Further, it will provide more sophisticated animal models for schizophrenia as well as better tools to validate these models. These studies may offer novel genetic and molecular clues to help explain the interactive nature of the impact genetic and environmental factors have on schizophrenia.
Translating Neuroscience Into Treatments And Public Health Policies For Addictive Behaviours
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Advances from neuroscience promise to revolutionise our ability to treat and prevent addictive disorders such as gambling, overeating and drug addiction. These developments may also have unexpected clinical consequences, undermine individuals’ belief in their control over their behaviour or increase stigma and discrimination. This project will develop clinical guidelines and public health policy recommendations to ensure that we realise the benefits of neuroscience while minimising social harms.
Psychiatric research to date has predominantly focused on understanding mental illness and ways to treat it. This research program instead aims to understand the characteristics of those people who are 'resilient' and able to bounce back from trauma and adversity and thrive. For the first time, it will establish the biological brain markers that define resilience, and the impact of genetics and environment in these pathways. This study will also validate personalised solutions to e-health cognit ....Psychiatric research to date has predominantly focused on understanding mental illness and ways to treat it. This research program instead aims to understand the characteristics of those people who are 'resilient' and able to bounce back from trauma and adversity and thrive. For the first time, it will establish the biological brain markers that define resilience, and the impact of genetics and environment in these pathways. This study will also validate personalised solutions to e-health cognitive training tools that aim to boost resilience.Read moreRead less
This research will develop cutting-edge computational tools and statistical methods to analyse, model and visualise the way in which the human brain is interconnected. The tools developed will be used to identify biological markers in the brain’s network of axonal circuitry (the connectome) that are valuable for diagnosis and prognosis of psychiatric disorders. This research will bring to fruition the exciting potential of connectomics in neuroscience and psychiatry.
Fighting Mental Disorders: Using Mental Imagery To Disarm Symptoms And Enhance Treatment.
Funder
National Health and Medical Research Council
Funding Amount
$415,218.00
Summary
This proposal will conduct the first pre-clinical and clinical research utilising mental imagery to disarm symptoms and enhance treatment of multiple mental disorders by controlling the strength of mental imagery. This fellowship represents the first attempt to alleviate symptoms by developing a cognitive-neuroscience method to control the strength of traumatic imagery and to show a causative means of enhancing imagery strength to boost the success rate of cognitive therapy involving imagery.
Psychosis contributes significantly to global disease burden, affecting more than 3% of the population when schizophrenia, schizoaffective disorder, and bipolar disorders are considered together. These conditions aggregate within families, and genetic risk factors do not conform to traditional diagnostic categories. My work employs brain-based classification techniques to derive subtypes of psychosis that dissect, and/or span the diagnostic categories, for investigation of modifiable genetic and ....Psychosis contributes significantly to global disease burden, affecting more than 3% of the population when schizophrenia, schizoaffective disorder, and bipolar disorders are considered together. These conditions aggregate within families, and genetic risk factors do not conform to traditional diagnostic categories. My work employs brain-based classification techniques to derive subtypes of psychosis that dissect, and/or span the diagnostic categories, for investigation of modifiable genetic and environmental risk factors for psychosis.Read moreRead less
The Role Of The Zinc Finger Transcriptional Repressor Znf238 During Nerve Cell Maturation
Funder
National Health and Medical Research Council
Funding Amount
$394,264.00
Summary
Proper foetal brain assembly is critical for brain function, but the underlying genetic mechanisms remain poorly defined. In this study, I will investigate a family of proteins that “turn on” neural gene expression in combination with another protein that “turns off” their expression during nerve cell development. Understanding this novel on/off mechanism for controlling gene expression in newborn nerve cells will further our understanding of how the brain is assembled.
Neurorestorative Rehabilitation In Children With Cerebral Palsy
Funder
National Health and Medical Research Council
Funding Amount
$451,716.00
Summary
Cerebral palsy (CP) is the most common physical disability (1 in 500) with life-long impact. The economic burden is AUS$1.47 billion/yr. Children have limitations in function which impacts daily activities and participation. Deficits in visual perception and learning have an impact on vocational aspirations. This program will test novel interventions (Action Observation training, constraint induced movement therapy, multi-modal web training) measuring broad outcomes and mechanisms with Advanced ....Cerebral palsy (CP) is the most common physical disability (1 in 500) with life-long impact. The economic burden is AUS$1.47 billion/yr. Children have limitations in function which impacts daily activities and participation. Deficits in visual perception and learning have an impact on vocational aspirations. This program will test novel interventions (Action Observation training, constraint induced movement therapy, multi-modal web training) measuring broad outcomes and mechanisms with Advanced Brain Imaging.Read moreRead less