Understanding The Causes Of Childhood Congenital Anomalies Of The Kidney And Urinary Tract
Funder
National Health and Medical Research Council
Funding Amount
$609,748.00
Summary
Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified ....Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified genes.Read moreRead less
How The Lateral Habenula Integrates Behavioral And Autonomic Functions: The VTA Dopamine Connection
Funder
National Health and Medical Research Council
Funding Amount
$819,904.00
Summary
When adverse events occur, the lateral habenula, an old brain nucleus, helps calculate the wisest corrective action by contributing to the “brake” that controls the brain’s dopamine reward system. Our research will show how the lateral habenula links corrective changes in behavior with coordinated changes in temperature. Understanding this link will greatly contribute to understanding the brain mechanisms that regulate our physiology during stressful situations and as part of mental illness.
The prediction of sleep/wake behaviour based on physiological and social factors. The prevalence of shiftwork has increased in Australia over the last few decades. Shiftworkers obtain less sleep, have greater difficulty maintaining good relationships, have poorer health, and are more likely to be injured at work than others. Using the largest dataset of its kind, we will substantially contribute to understanding the relationships between work hours, sleep, performance and safety. Ultimately, the ....The prediction of sleep/wake behaviour based on physiological and social factors. The prevalence of shiftwork has increased in Australia over the last few decades. Shiftworkers obtain less sleep, have greater difficulty maintaining good relationships, have poorer health, and are more likely to be injured at work than others. Using the largest dataset of its kind, we will substantially contribute to understanding the relationships between work hours, sleep, performance and safety. Ultimately, the project will answer a question critical to workplace safety - how much time off between shifts is needed to be alert and safe at work? The project will also produce tools to help industry design fatigue-friendly rosters, improving the safety, productivity and general well-being of shiftworkers in Australia and overseas.Read moreRead less
Preclinical Evaluation Of The Novel Therapeutic Compound APP96-110 In An Ovine Model Of Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$874,734.00
Summary
Traumatic brain injury (TBI) is a significant cause of death and disability, and yet there are currently no effective treatments to improve outcome following such an insult. Our laboratory has developed a novel therapeutic compound, by identifying an endogenous neuroprotective molecule, in the amyloid precursor protein and then identifying the active site and modifying it to improve its efficacy. We will be testing this compound in our sheep model of TBI.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453073
Funder
Australian Research Council
Funding Amount
$129,485.00
Summary
Establishment of a South Australian rTMS Facility. It is proposed to establish a South Australian Facility for rapid rate transcranial magnetic stimulation (TMS) which will be the only one in Australia. This Facility will provide enormous opportunities for collaborative cutting edge investigations into the role of the human cortical areas in a diverse range of tasks. For example, projects have been identified projects employing rTMS to study sensorimotor cortical plasticity, facilitate functiona ....Establishment of a South Australian rTMS Facility. It is proposed to establish a South Australian Facility for rapid rate transcranial magnetic stimulation (TMS) which will be the only one in Australia. This Facility will provide enormous opportunities for collaborative cutting edge investigations into the role of the human cortical areas in a diverse range of tasks. For example, projects have been identified projects employing rTMS to study sensorimotor cortical plasticity, facilitate functional recovery following stroke and investigate the mechanisms of savant behaviour. Provision of this Facility will provide further support for this productive and internationally renowned group of scientists to develop their research programs.Read moreRead less
Uncovering the processes underlying human category learning. There is a pervasive belief that complex tasks can somehow be learned via a 'smart' implicit or procedural learning mechanism, which operates independently of memory and attention. This idea has important implications for our understanding of cognition. If true, there seems little point in providing explicit instruction in such tasks, and efforts to do so are, at best, wasted time and, at worst, detrimental to the learning process. Th ....Uncovering the processes underlying human category learning. There is a pervasive belief that complex tasks can somehow be learned via a 'smart' implicit or procedural learning mechanism, which operates independently of memory and attention. This idea has important implications for our understanding of cognition. If true, there seems little point in providing explicit instruction in such tasks, and efforts to do so are, at best, wasted time and, at worst, detrimental to the learning process. This project will provide much-needed scrutiny of this idea and will help not only to re-orient our understanding of how we deal with complex information, but will also highlight issues about data interpretation that are fundamental for the research and wider communities.Read moreRead less
The effect of temperature biofeedback on sleep and cardiac autonomic tone in young and aged adults. Peripheral heat loss is reported to promote sleep onset. To date, however, most studies examining the thermoregulatory model of sleep onset have used sedative-hypnotics with both thermoregulatory and soporific effects. We propose that a better test of a causal relationship between peripheral heat loss and sleep can be achieved by using temperature biofeedback; a promising non-invasive and non-dr ....The effect of temperature biofeedback on sleep and cardiac autonomic tone in young and aged adults. Peripheral heat loss is reported to promote sleep onset. To date, however, most studies examining the thermoregulatory model of sleep onset have used sedative-hypnotics with both thermoregulatory and soporific effects. We propose that a better test of a causal relationship between peripheral heat loss and sleep can be achieved by using temperature biofeedback; a promising non-invasive and non-drug treatment that does not have a direct effect on sleep structures. We aim to test whether increased peripheral heat loss promotes sleep onset, whether the effects are mediated by changes in autonomic tone, and whether this relationship changes with age.Read moreRead less
Behavioural syndromes and social networks in sleepy lizards. Fauna in Australian ecosystems are threatened by habitat fragmentation, changing environments and the spread of exotic pathogens. To manage these threats we need to understand the behavioural flexibility of wildlife populations. This project focuses on how individual behavioural differences can influence social networks and consequently pathogen transmission. It will help to protect our fauna from invasive diseases and contribute to su ....Behavioural syndromes and social networks in sleepy lizards. Fauna in Australian ecosystems are threatened by habitat fragmentation, changing environments and the spread of exotic pathogens. To manage these threats we need to understand the behavioural flexibility of wildlife populations. This project focuses on how individual behavioural differences can influence social networks and consequently pathogen transmission. It will help to protect our fauna from invasive diseases and contribute to sustaining biodiversity. With better knowledge of how diseases spread we can develop more effective controls of those diseases, thereby protecting wildlife species, animal populations and Australian ecosystems. Read moreRead less
ARC Complex Open Systems Research Network. Complexity is the common frontier in the physical, biological and social sciences. This Network will link specialists in all three sciences through five generic conceptual and mathematical theme activities. It will promote research into how subsystems self-organise into new emergent structures when assembled into an open, non-equilibrium system. Outcomes will include new technologies and software tools and deeper understanding of fundamental questions i ....ARC Complex Open Systems Research Network. Complexity is the common frontier in the physical, biological and social sciences. This Network will link specialists in all three sciences through five generic conceptual and mathematical theme activities. It will promote research into how subsystems self-organise into new emergent structures when assembled into an open, non-equilibrium system. Outcomes will include new technologies and software tools and deeper understanding of fundamental questions in science. An essential function of the network will be introducing researchers end users to new tools and broadening the horizons of graduate students.Read moreRead less
Identification Of Genes For X-linked Mental Retardation.
Funder
National Health and Medical Research Council
Funding Amount
$675,228.00
Summary
We propose to identify novel heritable causes of intellectual disability using 22 large and well-characterised families from Australia. In these families we have refined the location of the genetic defect to the chromosome X and excluded the contribution of all so far known genes. We will achieve this using the technology of massive parallel sequencing. At the completion of the project we will have identified novel causes of intellectual disability and devised tests to identify them.