Australasian Cerebral Palsy Clinical Trials Network (AusCP-CTN): Optimising Interventions And Effective Services For Children With Cerebral Palsy
Funder
National Health and Medical Research Council
Funding Amount
$2,499,287.00
Summary
Cerebral Palsy (CP) is common and disability can be progressive so the heathcare burden is immense (0.14% GDP). Our Clinical trials network will improve early detection and develop new interventions to improve physical, cognitive and health outcomes for children with CP and their families. Recruitment from the national CP Register will address clinically important questions and test implementation of effective treatments. New Clinical Practice Guidelines will ensure translation internationally.
The Role Of The Zinc Finger Transcriptional Repressor Znf238 During Nerve Cell Maturation
Funder
National Health and Medical Research Council
Funding Amount
$394,264.00
Summary
Proper foetal brain assembly is critical for brain function, but the underlying genetic mechanisms remain poorly defined. In this study, I will investigate a family of proteins that “turn on” neural gene expression in combination with another protein that “turns off” their expression during nerve cell development. Understanding this novel on/off mechanism for controlling gene expression in newborn nerve cells will further our understanding of how the brain is assembled.
Sperm Competition and Sexual Selection. Competition between the sperm of two males within a single female has had profound implications for the evolution of male reproductive biology and behaviour. However, the reasons why females should mate with more than one male and thus generate sperm competition remains an evolutionary puzzle. Few studies have examined sperm competition from the female perspective and indeed, female perspectives are currently the subject of considerable debate. Using in ....Sperm Competition and Sexual Selection. Competition between the sperm of two males within a single female has had profound implications for the evolution of male reproductive biology and behaviour. However, the reasons why females should mate with more than one male and thus generate sperm competition remains an evolutionary puzzle. Few studies have examined sperm competition from the female perspective and indeed, female perspectives are currently the subject of considerable debate. Using insects as models I will examine the benefits of sperm competition for females and thereby the selective pressures that favour multiple mating. Moreover, I will determine whether sexual selection can act after copulation.Read moreRead less
Sperm competition and the evolution of ejaculates. This research will yield results that are at the cutting-edge in evolutionary biology, that will have a significant international impact, promoting the international profile of Australian science. The award will foster a world-class centre for research, and will train internationally competitive research scientists, adding to Australia's scientific capabilities. Through the development of IVF techniques in frogs, the research has the potential ....Sperm competition and the evolution of ejaculates. This research will yield results that are at the cutting-edge in evolutionary biology, that will have a significant international impact, promoting the international profile of Australian science. The award will foster a world-class centre for research, and will train internationally competitive research scientists, adding to Australia's scientific capabilities. Through the development of IVF techniques in frogs, the research has the potential to contribute to conservation outcomes for Australia's native frog fauna via captive breeding programs. The research groups connections with local infertility clinics has the potential to inform those studying human sperm in a time of growing concern over rising human infertility. Read moreRead less
The evolution of female mating frequency and its consequences. This project explores the evolutionary significance of female mating frequency for male and female reproductive biology. The research proposes to use innovative approaches to examine the evolution of ejaculate characteristics, will focus on the evolution of sperm form and function, and will examine the fitness benefits of promiscuity from the females' perspective. The research uses both vertebrates and invertebrates as model organi ....The evolution of female mating frequency and its consequences. This project explores the evolutionary significance of female mating frequency for male and female reproductive biology. The research proposes to use innovative approaches to examine the evolution of ejaculate characteristics, will focus on the evolution of sperm form and function, and will examine the fitness benefits of promiscuity from the females' perspective. The research uses both vertebrates and invertebrates as model organisms to test predictions and assumptions of theoretical models relevant to both internal and external modes of fertilization. The design of this project will allow cutting-edge, theoretically informed and experimentally grounded conclusions to be drawn regarding selection under sperm competition.Read moreRead less
Sperm Competition and Sexual Selection: answering fundamental questions in evolutionary biology. This research will yield results that are at the cutting-edge in evolutionary biology, that will have a significant international impact, promoting the international profile of Australian science. The award will build on an existing world-class centre of excellence for research, and will train internationally competitive research scientists, adding to Australia's scientific capabilities. The researc ....Sperm Competition and Sexual Selection: answering fundamental questions in evolutionary biology. This research will yield results that are at the cutting-edge in evolutionary biology, that will have a significant international impact, promoting the international profile of Australian science. The award will build on an existing world-class centre of excellence for research, and will train internationally competitive research scientists, adding to Australia's scientific capabilities. The research centre's connections with local fertility clinics, and their work on human sperm quality, has the potential to inform those studying human fertility.Read moreRead less
Ejaculate-mediated paternal effects on offspring fitness. This project aims to unravel the evolutionary importance of ejaculate-mediated paternal effects, through which paternal lifestyle factors, such as diet and exposure to toxicants, influence offspring growth and health independently of genes. By identifying the molecular mechanisms underlying these non-genetic sources of inheritance, their adaptive value, and their potential to fuel evolutionary change, the project expects to generate new k ....Ejaculate-mediated paternal effects on offspring fitness. This project aims to unravel the evolutionary importance of ejaculate-mediated paternal effects, through which paternal lifestyle factors, such as diet and exposure to toxicants, influence offspring growth and health independently of genes. By identifying the molecular mechanisms underlying these non-genetic sources of inheritance, their adaptive value, and their potential to fuel evolutionary change, the project expects to generate new knowledge that will be relevant across the biological, medical and agricultural sectors. Expected outcomes and benefits include building institutional and interdisciplinary collaborations and the development of tools to understand the evolutionary impacts of paternal lifestyle choices for offspring traits.Read moreRead less
Integrating Models of Memory for Serial Order. This research aims to compare and integrate computational models of memory for serial order. The applicants have independently developed theoretically novel models, and this collaboration will enable them to combine and strengthen their complementary perspectives.
Much psychologically important processing, for example speech perception and spelling, requires the representation and reproduction of serial order information. Existing models account ....Integrating Models of Memory for Serial Order. This research aims to compare and integrate computational models of memory for serial order. The applicants have independently developed theoretically novel models, and this collaboration will enable them to combine and strengthen their complementary perspectives.
Much psychologically important processing, for example speech perception and spelling, requires the representation and reproduction of serial order information. Existing models account for a wide range of data and collectively represent exciting progress in the understanding of basic mechanisms of memory. Can these models be unified and reconciled? To date, detailed comparisons of models are lacking. This proposal is for the applicants to elaborate and unify their contrasting theoretical approaches.
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Characterising and linking intermediate-level processing of pattern, motion and position in human vision? This work will advance basic science by enhancing understanding of human coding of image structure. The aim is to provide a common structure for understanding visual processing of form, motion and position. The work will help lift the international profile of Australian science. Explaining how the primitives for shape perception are extracted will also have consequences of potential economic ....Characterising and linking intermediate-level processing of pattern, motion and position in human vision? This work will advance basic science by enhancing understanding of human coding of image structure. The aim is to provide a common structure for understanding visual processing of form, motion and position. The work will help lift the international profile of Australian science. Explaining how the primitives for shape perception are extracted will also have consequences of potential economic benefit. One important aspect is the design of displays that allow observers to absorb complex information about rapidly changing situations. This work has the potential to provide information that enables display designers to optimise the efficiency of presentation of pattern and motion information.Read moreRead less
The role of time and similarity in short-term memory. The project examines the role of time and similarity in memory for serial order, with the long-term goal to construct a new computational model of short-term memory. The investigators are internationally known for their models, and the collaboration will enable them to combine their complementary perspectives into a unifying theory. Theory construction will be guided by two sets of studies: The first will delineate the circumstances, if any, ....The role of time and similarity in short-term memory. The project examines the role of time and similarity in memory for serial order, with the long-term goal to construct a new computational model of short-term memory. The investigators are internationally known for their models, and the collaboration will enable them to combine their complementary perspectives into a unifying theory. Theory construction will be guided by two sets of studies: The first will delineate the circumstances, if any, under which temporal separation at encoding affects memory. So far, we have shown that temporal distinctiveness has no effect on memory, unless people use temporal gaps to 'chunk' the list. The second set of studies will examine whether phonological similarity determines the strength of encoding.Read moreRead less