Modelling disease evolution and emergence. Approximately 75% of all emergent diseases have established in humans having switched from other species: Human Immunodeficiency Virus (HIV), Malaria, SARS (Severe Acute Respiratory Syndrome), Ebola, West Nile Virus and many more. Further, cross species infections put our biodiversity and economy at risk: plant and animal diseases entering Australia can destroy crops and at-risk native species. This project will provide for the first time the statistica ....Modelling disease evolution and emergence. Approximately 75% of all emergent diseases have established in humans having switched from other species: Human Immunodeficiency Virus (HIV), Malaria, SARS (Severe Acute Respiratory Syndrome), Ebola, West Nile Virus and many more. Further, cross species infections put our biodiversity and economy at risk: plant and animal diseases entering Australia can destroy crops and at-risk native species. This project will provide for the first time the statistical framework for scientists to assess risk of such diseases entering Australia as a key to combating them.Read moreRead less
Perception, interpretation, and the explanation of delusional beliefs. The occurrence of bizarrely false beliefs, called delusions, presents challenges, not only for clinical psychiatric practice, but also for psychology, neuroscience, and philosophy. The aim of this project is to make a distinctively philosophical contribution to our understanding of delusional beliefs by addressing three philosophical questions raised by the study of delusions, questions about perception, interpretation, and e ....Perception, interpretation, and the explanation of delusional beliefs. The occurrence of bizarrely false beliefs, called delusions, presents challenges, not only for clinical psychiatric practice, but also for psychology, neuroscience, and philosophy. The aim of this project is to make a distinctively philosophical contribution to our understanding of delusional beliefs by addressing three philosophical questions raised by the study of delusions, questions about perception, interpretation, and explanation. Answers to these questions will constitute substantial contributions to three central areas of philosophy, but their significance also extends beyond philosophy. They will impact on the scientific investigation of delusions and will contribute indirectly to the treatment and rehabilitation of sufferers.
Read moreRead less
Development of Acid Degradable Polymeric Nanoparticles for Intracellular and Tumour Site Selective Delivery of Drugs. There is an enormous need to develop effective anticancer drug delivery systems to reduce the social and economic impact of cancer. One of the most critical problems in tumour treatment is the lack of selective toxicity of anticancer drugs against tumour tissues. Our multidisciplinary team will aim to develop a novel polymer based system for tumour site-selective delivery of anti ....Development of Acid Degradable Polymeric Nanoparticles for Intracellular and Tumour Site Selective Delivery of Drugs. There is an enormous need to develop effective anticancer drug delivery systems to reduce the social and economic impact of cancer. One of the most critical problems in tumour treatment is the lack of selective toxicity of anticancer drugs against tumour tissues. Our multidisciplinary team will aim to develop a novel polymer based system for tumour site-selective delivery of anticancer drugs. Development of such advanced drug delivery systems will significantly enhance Australia`s power in biotechnology. Development and/or formation of strategies to improve the health quality of Australians, is an important anticipated outcome of this innovative project.Read moreRead less
Biomimetic Insights from Enamel: A Nano-mechanical and Nano-structural Investigation of a Natural Ceramic-like Biocomposite. Enamel is a naturally developed example of an optimised material structure that constitutes the hardest tissue in the human body. In addition it is exposed to severe mechanical and environmental challenges and must last the lifetime of the individual and unlike other tissue is unable to heal or repair itself. Understanding the factors controlling the amazing mechanical pr ....Biomimetic Insights from Enamel: A Nano-mechanical and Nano-structural Investigation of a Natural Ceramic-like Biocomposite. Enamel is a naturally developed example of an optimised material structure that constitutes the hardest tissue in the human body. In addition it is exposed to severe mechanical and environmental challenges and must last the lifetime of the individual and unlike other tissue is unable to heal or repair itself. Understanding the factors controlling the amazing mechanical properties of this tissue will be of great benefit for the design of bio-inspired materials and be important for the development of advanced materials for which Australia already has an enviable reputation.Read moreRead less
Development and Evaluation of Well-Defined Polymer-RNA Conjugates as Improved Therapeutics. Gene-based drugs offer an enormous potential to treat a wide range of diseases including, but not limited to, AIDS, hepatitis, and cancer. However, effective delivery of these drugs in body is needed to convert their therapeutic potential to clinically applicable treatments. Our multidisciplinary team will aim to develop novel, polymer-gene hybrid materials for efficient delivery of gene based therapeuti ....Development and Evaluation of Well-Defined Polymer-RNA Conjugates as Improved Therapeutics. Gene-based drugs offer an enormous potential to treat a wide range of diseases including, but not limited to, AIDS, hepatitis, and cancer. However, effective delivery of these drugs in body is needed to convert their therapeutic potential to clinically applicable treatments. Our multidisciplinary team will aim to develop novel, polymer-gene hybrid materials for efficient delivery of gene based therapeutics. Development of such advanced drug delivery systems will significantly enhance Australia`s power in biotechnology. Development and/or formation of new materials and strategies to improve the health quality of Australians, is an important anticipated outcome of this innovative project. Read moreRead less
Determination of benchmarking parameters for assessing the mechanical robustness of articular cartilage: a joint mathematical and experimental investigation. Osteoarthritis associated with the deterioration of the articular cartilage affects about 12% of Australian adults. This project will use an integrated approach combining novel mathematical modelling and an extensive experimental program to establish critical mechanical parameters, in particular, the fracture toughness of articular cartilag ....Determination of benchmarking parameters for assessing the mechanical robustness of articular cartilage: a joint mathematical and experimental investigation. Osteoarthritis associated with the deterioration of the articular cartilage affects about 12% of Australian adults. This project will use an integrated approach combining novel mathematical modelling and an extensive experimental program to establish critical mechanical parameters, in particular, the fracture toughness of articular cartilage and will incorporate the unique structure of the dissimilar layers in articular cartilage. It will be used to study how these resist the propagation of an initiated crack and will offer significant insight into the desirable fracture properties of any replacement material for articular cartilage and will provide a basis for assessing replacement biomaterials.Read moreRead less
Unifying Modern Approaches in Machine Learning. The proposed research will lead to better algorithms for some important machine learning problems that could lead to better tools for extracting useful knowledge from data such as in bioinformatics and sensor networks; it will strengthen an international collaboration with one of the world's top centres of machine learning research; it will contribute to an open source toolkit of machine learning algorithms which will put Australia on the map as a ....Unifying Modern Approaches in Machine Learning. The proposed research will lead to better algorithms for some important machine learning problems that could lead to better tools for extracting useful knowledge from data such as in bioinformatics and sensor networks; it will strengthen an international collaboration with one of the world's top centres of machine learning research; it will contribute to an open source toolkit of machine learning algorithms which will put Australia on the map as a provider of sophisticated machine learning software; it will provide training opportunities for several PhD students and a postdoc to work with some of the best machine learning researchers in the world.Read moreRead less
Coordination and communication in critical care: Assessing potential technology support. This project will examine temporal coordination demands of busy critical care environments, with the goal of developing better models and tools for evaluating the impact of information and communication technology (ICT) innovation. Millions of dollars can be wasted on healthcare ICT updates when the nature of critical care work, the means of communication, and temporal coordination demands are not fully unde ....Coordination and communication in critical care: Assessing potential technology support. This project will examine temporal coordination demands of busy critical care environments, with the goal of developing better models and tools for evaluating the impact of information and communication technology (ICT) innovation. Millions of dollars can be wasted on healthcare ICT updates when the nature of critical care work, the means of communication, and temporal coordination demands are not fully understood. The outcome of this project will be better conceptual and computational tools for assessing the impact of ICT innovation on safety-critical systems such as healthcare, so providing more cost-effective ICT solutions where there is rapidly-evolving ICT innovation.Read moreRead less
Teimu (The Garden of Dreams): aural and aesthetic attributes of Japanese gardens as models for spatial environments. Traditional Japanese garden design has greatly influenced both 20C Western landscape designers and composers of Western art music. By investigating the aural and aesthetic attributes of five renowned Japanese gardens, RMIT and University of Melbourne researchers will seek out spatial sound designs that could enhance sound quality in urban environments and provide a pioneering app ....Teimu (The Garden of Dreams): aural and aesthetic attributes of Japanese gardens as models for spatial environments. Traditional Japanese garden design has greatly influenced both 20C Western landscape designers and composers of Western art music. By investigating the aural and aesthetic attributes of five renowned Japanese gardens, RMIT and University of Melbourne researchers will seek out spatial sound designs that could enhance sound quality in urban environments and provide a pioneering approach to architectural modeling and the built environment. This project has long-term cross-disciplinary implications. The results and methods contained in this project may assist in innovative sound design for new media applications, better listening environments in urban areas, unique approaches for data modeling, and a catalyst for future design strategies.Read moreRead less
Formation, degradation and migration of a yet unidentified POP source. Australia has recently ratified the Stockholm Convention, targeting persistent organic pollutants (POPs) for global reduction and elimination. A significant gap exists, however, in understanding sources and pathways of POPs in Australia, and subtropical/tropical environments. Previous research has shown an extensive POP contamination in coastal Australia, and exposure of biota to elevated levels. The present study will evalua ....Formation, degradation and migration of a yet unidentified POP source. Australia has recently ratified the Stockholm Convention, targeting persistent organic pollutants (POPs) for global reduction and elimination. A significant gap exists, however, in understanding sources and pathways of POPs in Australia, and subtropical/tropical environments. Previous research has shown an extensive POP contamination in coastal Australia, and exposure of biota to elevated levels. The present study will evaluate the formation, degradation and migration of POPs, and their significance to Australia's past, present and future emissions. The outcomes will allow identification of sources, their prioritization for elimination and exposure prevention, and ultimately serve to protect the environment and human health in Australia.Read moreRead less