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Novel Therapeutic Interventions To Increase Blood Flow To Skeletal Muscle
Funder
National Health and Medical Research Council
Funding Amount
$360,750.00
Summary
Over the past decade it has become clear that the cytokine interleukin (IL)-6 is produced in and released from tissues such as fat and muscle to mediate metabolic processes. In this respect, it acts in a hormone like manner. During this period it has also become apparent that the hormone insulin increases blood flow to skeletal muscle. There is emerging evidence that IL-6 plays a role, not only in metabolic and signalling processes within skeletal muscle, but also in blood flow. This project wil ....Over the past decade it has become clear that the cytokine interleukin (IL)-6 is produced in and released from tissues such as fat and muscle to mediate metabolic processes. In this respect, it acts in a hormone like manner. During this period it has also become apparent that the hormone insulin increases blood flow to skeletal muscle. There is emerging evidence that IL-6 plays a role, not only in metabolic and signalling processes within skeletal muscle, but also in blood flow. This project will determine whether the cytokine IL-6 is a viable therapeutic target in the treatment of blood flow disorders in patients with type 2 diabetes. This has major ramifications since type 2 diabetes has reached pandemic levels in Australia and is estimated to cost the community approximately 800 million dollars per year.Read moreRead less
Effect Of Sex Steroids, Inflammation, Environmental And Biopsychosocial Factors On Cardiometabolic Disease Risk In Men
Funder
National Health and Medical Research Council
Funding Amount
$1,817,271.00
Summary
Heart disease is more frequent and occurs at an earlier age in men than women. The reason is unknown. Apart from obesity and associated disturbances of metabolism, changes in sex hormones such as testosterone, together with the effects of inflammation may be important, and may in turn be affected by environment, lifestyle behaviours, and stress. To untangle these relationships, we will use cutting edge technology, in a large sample of men, in partnership with other international scientists.
Identifying The Epigenomic Fingerprint Of Coronary Heart Disease In Chinese Adults With Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$596,663.00
Summary
Once people get diabetes, even good glucose control may be insufficient to prevent its complications. Diabetes results in molecular imprinting contributing to an increased risk of heart disease. We believe it is possible to identify this imprinted risk by a sophisticated analysis of a standard blood sample. Validating this hypothesis will lead to new biomarkers to identify individuals at increased risk of heart attacks as well as new strategies for the prevention and treatment of heart disease.
UNLOCKING GENETIC FACTORS PREDICTING TYPE 2 DIABETES COMPLICATIONS FOR CLINICAL PRACTICE: THE FIELD STUDY
Funder
National Health and Medical Research Council
Funding Amount
$2,503,122.00
Summary
Heart disease, stroke, eye and kidney diseases in diabetes have both environmental and genetic predispositions. With over 5000 Australians with diabetes, this research in the FIELD study is to identify the important genetic contributors to these complications. It will explore how the genetic features cause disease and whether the most important ones can be screened for in simple blood tests. It will also examine whether the genetic damage of ageing is accelerated in diabetes.
Contribution Of The Peri-renal Environment To Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$335,008.00
Summary
This proposal will investigate the peri-renal adipose tissue phenotype and if factors derived from this local adipose tissue depot can influence kidney function